Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Ronald W. Irwin"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Allopregnanolone (Allo), a neurosteroid, has emerged as a promising promoter of endogenous regeneration in brain. In a mouse model of Alzheimer’s disease, Allo induced neurogenesis, oligodendrogenesis, white matter generation and cholesterol homeos
Externí odkaz:
https://doaj.org/article/5df76ff417d645d289d651c55a123122
Publikováno v:
Frontiers in Endocrinology, Vol 2 (2012)
The proliferative pool and regenerative potential of neural stem cells diminishes with age, a phenomenon that may be exacerbated in prodromal and mild Alzheimer’s disease (AD) brains. In parallel, the neuroactive progesterone metabolite, allopregna
Externí odkaz:
https://doaj.org/article/ad7da3d6a5fc417cbc35c6e88ad60d6b
Autor:
Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128313 (2015)
To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intr
Externí odkaz:
https://doaj.org/article/040fc371d0ab4f1ca16b64dd413384d7
Publikováno v:
Pharmaceutical research. 38(3)
The biodistribution imaging kinetics of near-infrared monoamine oxidase inhibitor (NMI) are reported here.NMI was administered intravenously or orally to mice and detected by NIR fluorescence optical imaging within minutes and the longitudinal signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ada3ade81413f7a4c663b605564bc9e
https://pubmed.ncbi.nlm.nih.gov/33709330
https://pubmed.ncbi.nlm.nih.gov/33709330
Autor:
Ming-De Wang, Torbjörn Bäckström, Maja Johansson, Roberta Diaz Brinton, Ronald W. Irwin, J. Sjöstedt, Sara K. Bengtsson
Publikováno v:
Neurobiology of Stress
Neurobiology of Stress, Vol 12, Iss, Pp-(2020)
Neurobiology of Stress, Vol 12, Iss, Pp-(2020)
Cognitive dysfunction, dementia and Alzheimer's disease (AD) are increasing as the population worldwide ages. Therapeutics for these conditions is an unmet need. This review focuses on the role of the positive GABA-A receptor modulating steroid allop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89174a00edf462af5b8d997533e94f0f
http://europepmc.org/articles/PMC6948369
http://europepmc.org/articles/PMC6948369
Autor:
Roberta Diaz Brinton, Michael A. Rogawski, Claudia Lopez, Gerson D. Hernandez, Wendy J. Mack, Ronald W. Irwin, Kathleen E. Rodgers, Lon S. Schneider, Naoko Kono, Maunil K. Desai
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b57e195d45a3c5f618ee87f8f4ddcf55
https://doi.org/10.1016/j.jalz.2018.06.055
https://doi.org/10.1016/j.jalz.2018.06.055
Autor:
Ronald W. Irwin, Marissa McGilvrey, Mayur Prajapati, Khyatiben V. Pathak, Patrick Pirrotte, Maunil K. Desai, Roberta Diaz Brinton
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2630ab227c517db22c761b20e292b277
https://doi.org/10.1016/j.jalz.2018.06.815
https://doi.org/10.1016/j.jalz.2018.06.815
Autor:
Ronald W. Irwin, Patrick E. Adams, Cecilia R Giulivi, Kyoungmi Kim, Michael A. Rogawski, John M Olichney, Nika Roa Carrillo, Andrea Schneider, Susan M. Rivera, Flora Tassone, A. M. Trivedi, J. Y. Wang, Randi J Hagerman, N. Lubarr, Chun-Yi Wu, Roberta Diaz Brinton, Jin Chen Yang
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol 14, iss 4
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative disorder affecting approximately 45% of male and 16% of female carriers of the FMR1 premutation over the age of 50years. Currently, no effective treatment is availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5d0a4d1e2a79537c14ca34f2ba33e3
https://escholarship.org/uc/item/9gw07979
https://escholarship.org/uc/item/9gw07979
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b296962d53e3109c52fb028738f8cf
https://doi.org/10.1016/j.jalz.2017.06.823
https://doi.org/10.1016/j.jalz.2017.06.823
Autor:
Naoko Kono, Gerson D. Hernandez, Lon S. Schneider, Roberta Diaz Brinton, Claudia Lopez, Wendy J. Mack, Christine M. Solinsky, Ronald W. Irwin
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be72ae061261e4a11c1700d91ab2a37e
https://doi.org/10.1016/j.jalz.2017.06.1884
https://doi.org/10.1016/j.jalz.2017.06.1884