Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Ronald W. Hughen"'
Autor:
Lili Sun, Jie Zhang, Changshan Niu, Cassandra E. Deering-Rice, Ronald W. Hughen, John G. Lamb, Katherine Rose, Kevin M. Chase, Marysol Almestica-Roberts, Markel Walter, Eric W. Schmidt, Alan R. Light, Baldomero M. Olivera, Christopher A. Reilly
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 68-81 (2023)
Pain is often debilitating, and current treatments are neither universally efficacious nor without risks. Transient receptor potential (TRP) ion channels offer alternative targets for pain relief, but little is known about the regulation or identitie
Externí odkaz:
https://doaj.org/article/6bb12ec7d65448d6a83796dbcdf8242d
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 323:R221-R226
The exercise pressor reflex (EPR), a neurocirculatory control mechanism, is exaggerated in hypertensive humans and rats. Disease-related abnormalities within the afferent arm of the reflex loop, including mechano- and metabosensitive receptors locate
Autor:
Cheryl Dowell, Zhenjian Lin, Baldomero M. Olivera, Ronald W. Hughen, Randall T. Peterson, Albebson L. Lim, Jie Zhang, Kevin Chase, J. Michael McIntosh, Noemi D. Paguigan, Lee S. Leavitt, Eric W. Schmidt, Shrinivasan Raghuraman, Manju Karthikeyan, Christopher A. Reilly, Cassandra E. Deering-Rice, Jortan O. Tun, Alan R. Light
Publikováno v:
ACS Chem Neurosci
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii, and their prey, Didemnum molle, tunicates. The chemical structures of molleamines were
Autor:
Shrinivasan Raghuraman, Joshua P. Torres, Baldomero M. Olivera, Ronald W. Hughen, Manju Karthikeyan, Chang-Shan Niu, Kevin Chase, Zhenjian Lin, Alan R. Light, Marco Bortolato, Jie Zhang, Lee S. Leavitt, Lili Sun, Noemi D. Paguigan, Roberto Cadeddu, Eric W. Schmidt, Christopher A. Reilly
Publikováno v:
Journal of Medicinal Chemistry. 64:7033-7043
In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (1-5), from the hypobranchial gland of the mollusk Conus geographus. Compounds 1-5 were active in a mouse dorsal root ganglion (DRG) as
Autor:
Manju Karthikeyan, Jortan O. Tun, Kevin Chase, Lee S. Leavitt, Albebson L. Lim, Shrinivasan Raghuraman, Cheryl Dowell, Ronald W. Hughen, Alan R. Light, Baldomero M. Olivera, J. M. McIntosh, Jie Zhang, Noemi D. Paguigan, Eric W. Schmidt, Christopher A. Reilly, Zhenjian Lin, Cassandra E. Deering-Rice, Randall T. Peterson
In our efforts to discover new drugs to treat pain, we identified molleamines A-E (1-5) as major neuroactive components of the sea slug, Pleurobranchus forskalii and their prey, Didemnum molle tunicates. The chemical structures of molleamines were el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93867834e3506529c91e592477639ba
https://doi.org/10.1101/2021.05.17.444536
https://doi.org/10.1101/2021.05.17.444536
Autor:
Changshan, Niu, Lee S, Leavitt, Zhenjian, Lin, Noemi D, Paguigan, Lili, Sun, Jie, Zhang, Joshua P, Torres, Shrinivasan, Raghuraman, Kevin, Chase, Roberto, Cadeddu, Manju, Karthikeyan, Marco, Bortolato, Christopher A, Reilly, Ronald W, Hughen, Alan R, Light, Baldomero M, Olivera, Eric W, Schmidt
Publikováno v:
Journal of medicinal chemistry. 64(10)
In a program to identify pain treatments with low addiction potential, we isolated five steroids, conosteroids A-E (
Autor:
Markus Amann, Russell S. Richardson, Jie Zhang, Ronald W. Hughen, Alan R. Light, Oh Sung Kwon, Joshua C. Weavil
Publikováno v:
The FASEB Journal. 33
Autor:
Ronald W. Hughen, Andrea T. White, Alan R. Light, Kathleen C. Light, Timothy A. VanHaitsma, Lucinda Bateman
Publikováno v:
Pain Research and Treatment
Pain Research and Treatment, Vol 2015 (2015)
Pain Research and Treatment, Vol 2015 (2015)
Pregabalin, an approved treatment for fibromyalgia (FM), has been shown to decrease sympathetic nervous system (SNS) activity and inhibit sympathetically maintained pain, but its effects on exercise responses have not been reported. Methods. Using a
Autor:
Andrea T. White, Akiko Okifuji, Eli Iacob, Ronald W. Hughen, Kathleen C. Light, Gary W. Donaldson, Alan R. Light
Publikováno v:
Arthritis Care & Research. 68:132-140
Objective To determine if independent candidate genes can be grouped into meaningful biologic factors, and whether these factors are associated with the diagnosis of chronic fatigue syndrome (CFS) and fibromyalgia syndrome (FMS), while controlling fo
Autor:
Eric W. Schmidt, Ronald W. Hughen, Baldomero M. Olivera, Margo G. Haygood, Malcolm M. Zachariah, Gisela P. Concepcion, Lenny Marett, Zhenjian Lin, Alan R. Light, Russell W. Teichert
Publikováno v:
Journal of Natural Products
The griseorhodins belong to a family of extensively modified aromatic polyketides that exhibit activities such as inhibition of HIV reverse transcriptase and human telomerase. The vast structural diversity of this group of polyketides is largely intr