Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ronald W Clark"'
Autor:
Derek M Erion, Amanda Lapworth, Paul A Amor, Guoyun Bai, Nicholas B Vera, Ronald W Clark, Qingyun Yan, Yimin Zhu, Trenton T Ross, Julie Purkal, Matthew Gorgoglione, Guodong Zhang, Vinicius Bonato, Levenia Baker, Nicole Barucci, Theresa D'Aquila, Alan Robertson, Robert J Aiello, Jiangli Yan, Jeff Trimmer, Timothy P Rolph, Jeffrey A Pfefferkorn
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97139 (2014)
Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importan
Externí odkaz:
https://doaj.org/article/646e9e91d00f42f6a75e558c5e50e7cf
Autor:
Kentaro Futatsugi, Shawn Cabral, Daniel W. Kung, Kim Huard, Esther Lee, Markus Boehm, Jonathan Bauman, Ronald W. Clark, Steven B. Coffey, Collin Crowley, Anne-Marie Dechert-Schmitt, Matthew S. Dowling, Robert Dullea, James R. Gosset, Amit S. Kalgutkar, Kou Kou, Qifang Li, Yajing Lian, Paula M. Loria, Allyn T. Londregan, Mark Niosi, Christine Orozco, John C. Pettersen, Jeffrey A. Pfefferkorn, Jana Polivkova, Trenton T. Ross, Raman Sharma, Ingrid A. Stock, Gregory Tesz, Hanna Wisniewska, Bryan Goodwin, David A. Price
Publikováno v:
Journal of medicinal chemistry. 65(22)
Discovery efforts leading to the identification of ervogastat (PF-06865571), a systemically acting diacylglycerol acyltransferase (DGAT2) inhibitor that has advanced into clinical trials for the treatment of non-alcoholic steatohepatitis (NASH) with
Autor:
Ronald W. Clark, David Cunningham, Yang Cong, Timothy A. Subashi, George T. Tkalcevic, David B. Lloyd, James G. Boyd, Boris A. Chrunyk, George A. Karam, Xiayang Qiu, Ing-Kae Wang, Omar L. Francone
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)
The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t
Externí odkaz:
https://doaj.org/article/90ebce87c8a64100a15f3130a1645823
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 3, Pp 537-552 (2006)
We have identified a series of potent cholesteryl ester transfer protein (CETP) inhibitors, one member of which, torcetrapib, is undergoing phase 3 clinical trials. In this report, we demonstrate that these inhibitors bind specifically to CETP with 1
Externí odkaz:
https://doaj.org/article/65964bfc21ea4844aa60df2bb08c7a77
Autor:
Adhiraj Lanba, Yan Weng, Veena Somayaji, Ronald W. Clark, Michelle Rossulek, Jeffrey R. Chabot, Dongmei Li, Derek M. Erion, Bryan Goodwin, Martin B. Brenner, Yingjiang Zhou, Saswata Talukdar, Bryn M. Owen, Kathryn E. Gropp, Roberto A. Calle, Timothy P. Rolph, Jennifer Q. Dong, Jeffrey K. Trimmer
Publikováno v:
Cell Metabolism. 23:427-440
FGF21 plays a central role in energy, lipid, and glucose homeostasis. To characterize the pharmacologic effects of FGF21, we administered a long-acting FGF21 analog, PF-05231023, to obese cynomolgus monkeys. PF-05231023 caused a marked decrease in fo
Autor:
Carlin Okerberg, Timothy M. Coskran, Kou Kou, Walter F. Bobrowski, Irani Khatun, Nicholas B. Vera, Derek M. Erion, Bryan Goodwin, Ronald W. Clark
Publikováno v:
Journal of Biological Chemistry. 291:2602-2615
Dietary triglycerides (TG) are absorbed by the enterocytes of the small intestine after luminal hydrolysis into monacylglycerol and fatty acids. Before secretion on chylomicrons, these lipids are reesterified into TG, primarily through the monoacylgl
Autor:
Shawn Cabral, Ronald W. Clark, Philip A. Carpino, Csilla C. Jorgensen, Wenhua Jiao, Julie Purkal, Matthew S. Dowling, Suvi T. M. Orr, David Hepworth, Steven B. Coffey, Mark Niosi, Gary Erik Aspnes, Michael Herr, James R. Gosset, Kentaro Futatsugi, Theunis C. Goosen, Derek M. Erion, Bryan Goodwin, Kou Kou, Kay Ahn, Qifang Li, John C. Pettersen, Sylvie Perez, Sophie Y. Lavergne, Brandon Pabst, Daniel W. Kung, Scott Bader, Jeffrey A. Pfefferkorn, Kyuha Lee, Jianwei Bian, Markus Boehm
Publikováno v:
Journal of Medicinal Chemistry. 58:7173-7185
The medicinal chemistry and preclinical biology of imidazopyridine-based inhibitors of diacylglycerol acyltransferase 2 (DGAT2) is described. A screening hit 1 with low lipophilic efficiency (LipE) was optimized through two key structural modificatio
Autor:
Jingsong Cao, Yingjiang Zhou, Ruth E. Gimeno, Ronald W. Clark, Mylene Perreault, James F. Tobin, Bryan Goodwin, Ariful Qadri, Haibing Peng, Sylvie Perez, Qingcong Lin
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 306:E1176-E1187
Glycerol-3-phosphate acyltransferases (GPATs) catalyze the first step in the synthesis of glycerolipids and glycerophospholipids. Microsomal GPAT, the major GPAT activity, is encoded by at least two closely related genes, GPAT3 and GPAT4. To investig
Autor:
David Cunningham, James G. Boyd, George T. Tkalcevic, Ing-Kae Wang, George A. Karam, Omar L. Francone, Yang Cong, Ronald W. Clark, Boris A. Chrunyk, Timothy A. Subashi, Xiayang Qiu, David B. Lloyd
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 5, Pp 967-974 (2010)
The CETP inhibitor, torcetrapib, was prematurely terminated from phase 3 clinical trials due to an increase in cardiovascular and noncardiovascular mortality. Because nearly half of the latter deaths involved patients with infection, we have tested t
Autor:
Ronald W. Clark, Margaret E. Brousseau
Publikováno v:
Drug Discovery Today: Therapeutic Strategies. 2:117-124
Physical inactivity and obesity have brought metabolic syndrome to prominence as a major risk factor for cardiovascular disease and death. Characterized by a constellation of lipid and other abnormalities, the condition requires better tolerated, mor