Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Ronald W, Helms"'
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Stroke with transfusions changing to hydroxyurea (SWiTCH): A phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload
Autor: Ronald W. Helms, Rathi V. Iyer, Zora R. Rogers, Scott T. Miller, Russell E. Ware, Nicole A. Mortier, Myron A. Waclawiw, Lee Hilliard, William H. Schultz, Nancy A. Yovetich, J. Paul Scott, Ofelia A. Alvarez
Publikováno v: Pediatric Blood & Cancer. 57:1011-1017
Background Stroke occurs in 5–10% of children with sickle cell anemia (SCA) and has a high (>50%) risk of recurrence without therapy. Chronic monthly erythrocyte transfusions effectively prevent recurrent stroke, but their long term use is limited
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::182278130d86d1c77d2dadc715e12687
https://doi.org/10.1002/pbc.23145
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2
Precise definitions of some terminology for longitudinal clinical trials: subjects, patient populations, analysis sets, intention to treat, and related terms
Autor: Ronald W. Helms
Publikováno v: Pharmaceutical statistics. 15(6)
Biostatisticians recognize the importance of precise definitions of technical terms in randomized controlled clinical trial (RCCT) protocols, statistical analysis plans, and so on, in part because definitions are a foundation for subsequent actions.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2341e06873f5a2bd795417b5cabd946f
https://pubmed.ncbi.nlm.nih.gov/27620652
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3
A method for fitting regression splines with varying polynomial order in the linear mixed model
Autor: Paul W. Stewart, Lloyd J. Edwards, Ronald W. Helms, James E. MacDougall
Publikováno v: Statistics in Medicine. 25:513-527
The linear mixed model has become a widely used tool for longitudinal analysis of continuous variables. The use of regression splines in these models offers the analyst additional flexibility in the formulation of descriptive analyses, exploratory an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5a62ef86ef59825ee16c6698db2cc0
https://doi.org/10.1002/sim.2232
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5
Effect of hydroxyurea on growth in children with sickle cell anemia: Results of the HUG-KIDS study
Autor: Rupa Redding-Lallinger, Kwaku Ohene-Frempong, Lori Styles, Henry Lynn, Myron A. Waclawiw, Beatrice E. Gee, Ronald W. Helms, Elliott Vichinsky, Russell E. Ware, Kim Smith-Whitley, Winfred C. Wang, Thomas R. Kinney
Publikováno v: The Journal of Pediatrics. 140:225-229
Objectives: Although hydroxyurea is effective in treating adults with sickle-cell anemia (SCA), there is concern that it may adversely affect growth in children. We report the growth characteristics of patients in the Phase I-II pediatric hydroxyurea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28caeda248dddd128e464c7679e636
https://doi.org/10.1067/mpd.2002.121383
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6
Predictors of fetal hemoglobin response in children with sickle cell anemia receiving hydroxyurea therapy
Autor: Charles Daeschner, Russell E. Ware, Barry Eggleston, Lori Styles, Kim Smith-Whitley, Thomas R. Kinney, Rupa Redding-Lallinger, Winfred C. Wang, Ronald W. Helms, Beatrice E. Gee, Kwaku Ohene-Frempong
Publikováno v: Blood. 99:10-14
In the phase I/II pediatric hydroxyurea safety trial (HUG-KIDS), school-aged children with sickle cell anemia receiving hydroxyurea at the maximally tolerated dose (MTD) had variable increases in the percentage of fetal hemoglobin (%HbF). To identify
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d782bc65d5a39404dfa84e44575e5878
https://doi.org/10.1182/blood.v99.1.10
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7
Metrics and Best Practices in Clinical Data Management: Conclusions of a Dia Roundtable Workshop
Autor: Ronald W. Helms, Paula J. Fillow, Rosemary Murphy, Ron Fitzmartin, Linda M. Talley, Sharon A. Miller
Publikováno v: Drug Information Journal. 35:681-694
Metrics are statistics that characterize the quality, productivity, speed (performance), or cost of one or more clinical data management activities. Even though clinical data management metrics have been used for decades, little effort has been made
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9e3571b142c546a9fd78f89b0909dbd
https://doi.org/10.1177/009286150103500306
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8
Data Quality Issues in Electronic Data Capture
Autor: Ronald W. Helms
Publikováno v: Drug Information Journal. 35:827-837
Electronic data capture (EDC) systems hold the potential for dramatically reducing the time and effort required to acquire and process clinical trials data. However, these systems raise a number of data quality issues. This paper presents some ancien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::721da38bba7d1350e8f6c6fb18d1fc55
https://doi.org/10.1177/009286150103500320
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9
Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model
Autor: John N. Krieger, Joseph J. Eron, Susan A. Fiscus, Pietro Vernazza, Pranab Kumar Sen, Myron S. Cohen, Hrishikesh Chakraborty, Bruce K. Patterson, Ronald W. Helms, Robert W. Coombs
Publikováno v: AIDS. 15:621-627
Objective: To develop a model to predict transmission of HIV-1 from men to women. Design: HIV-1 in seminal plasma, and endocervical CCR5 receptors were correlated with epidemiological studies of HIV-1 transmission to develop a probabilistic model. Se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4678c21d609c44788931570dcf8299
https://doi.org/10.1097/00002030-200103300-00012
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10
A discriminant analysis extension to mixed models
Autor: Steven M. Snapinn, Lisa Tomasko, Ronald W. Helms
Publikováno v: Statistics in Medicine. 18:1249-1260
Discriminant analysis is commonly used to classify an observation into one of two (or more) populations on the basis of correlated measurements. Classical discriminant analysis approaches require complete data for all observations. Our extension enab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bb32f90b73b3b2e6b03e2c740de86b8
https://doi.org/10.1002/(sici)1097-0258(19990530)18:10<1249::aid-sim125>3.0.co
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