Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ronald T. Toth"'
Autor:
Ronald T. Toth, Robert D. Sitrin, Neha Sahni, Stanley J. Cryz, John M. Hickey, David B. Volkin, George A. Robertson, Sanjeev Agarwal, Sangeeta B. Joshi
Publikováno v:
Journal of Pharmaceutical Sciences
Although live attenuated Rotavirus (RV) vaccines are available globally to provide protection against enteric RV disease, efficacy is substantially lower in low- to middle-income settings leading to interest in alternative vaccines. One promising can
Autor:
Huaying Zhao, Rodolfo Ghirlando, Carlos Alfonso, Fumio Arisaka, Ilan Attali, David L Bain, Marina M Bakhtina, Donald F Becker, Gregory J Bedwell, Ahmet Bekdemir, Tabot M D Besong, Catherine Birck, Chad A Brautigam, William Brennerman, Olwyn Byron, Agnieszka Bzowska, Jonathan B Chaires, Catherine T Chaton, Helmut Cölfen, Keith D Connaghan, Kimberly A Crowley, Ute Curth, Tina Daviter, William L Dean, Ana I Díez, Christine Ebel, Debra M Eckert, Leslie E Eisele, Edward Eisenstein, Patrick England, Carlos Escalante, Jeffrey A Fagan, Robert Fairman, Ron M Finn, Wolfgang Fischle, José García de la Torre, Jayesh Gor, Henning Gustafsson, Damien Hall, Stephen E Harding, José G Hernández Cifre, Andrew B Herr, Elizabeth E Howell, Richard S Isaac, Shu-Chuan Jao, Davis Jose, Soon-Jong Kim, Bashkim Kokona, Jack A Kornblatt, Dalibor Kosek, Elena Krayukhina, Daniel Krzizike, Eric A Kusznir, Hyewon Kwon, Adam Larson, Thomas M Laue, Aline Le Roy, Andrew P Leech, Hauke Lilie, Karolin Luger, Juan R Luque-Ortega, Jia Ma, Carrie A May, Ernest L Maynard, Anna Modrak-Wojcik, Yee-Foong Mok, Norbert Mücke, Luitgard Nagel-Steger, Geeta J Narlikar, Masanori Noda, Amanda Nourse, Tomas Obsil, Chad K Park, Jin-Ku Park, Peter D Pawelek, Erby E Perdue, Stephen J Perkins, Matthew A Perugini, Craig L Peterson, Martin G Peverelli, Grzegorz Piszczek, Gali Prag, Peter E Prevelige, Bertrand D E Raynal, Lenka Rezabkova, Klaus Richter, Alison E Ringel, Rose Rosenberg, Arthur J Rowe, Arne C Rufer, David J Scott, Javier G Seravalli, Alexandra S Solovyova, Renjie Song, David Staunton, Caitlin Stoddard, Katherine Stott, Holger M Strauss, Werner W Streicher, John P Sumida, Sarah G Swygert, Roman H Szczepanowski, Ingrid Tessmer, Ronald T Toth, Ashutosh Tripathy, Susumu Uchiyama, Stephan F W Uebel, Satoru Unzai, Anna Vitlin Gruber, Peter H von Hippel, Christine Wandrey, Szu-Huan Wang, Steven E Weitzel, Beata Wielgus-Kutrowska, Cynthia Wolberger, Martin Wolff, Edward Wright, Yu-Sung Wu, Jacinta M Wubben, Peter Schuck
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126420 (2015)
Analytical ultracentrifugation (AUC) is a first principles based method to determine absolute sedimentation coefficients and buoyant molar masses of macromolecules and their complexes, reporting on their size and shape in free solution. The purpose o
Externí odkaz:
https://doaj.org/article/3bd91e8f42734f39965350067490e003
Autor:
Brittney J. Mills, Samantha E. Pace, David D. Weis, Reza Esfandiary, David B. Volkin, C. Russell Middaugh, Ronald T. Toth, Sangeeta B. Joshi
Publikováno v:
Journal of Pharmaceutical Sciences. 107:1009-1019
Antibodies are molecules that exhibit diverse conformational changes on different timescales, and there is ongoing interest to better understand the relationship between antibody conformational dynamics and storage stability. Physical stability data
Autor:
David D. Weis, Brittney J. Mills, Steven M. Bishop, Sangeeta B. Joshi, C. Russell Middaugh, David B. Volkin, Ronald T. Toth, Reza Esfandiary
Publikováno v:
Analytical Chemistry. 89:8931-8941
A barrier to the use of hydrogen exchange-mass spectrometry (HX-MS) in many contexts, especially analytical characterization of various protein therapeutic candidates, is that differences in temperature, pH, ionic strength, buffering agent, or other
Autor:
Siva Krishna Angalakurthi, Nicholas J. Mantis, Ronald T. Toth, Andrea Bazzoli, C. Russell Middaugh, John Karanicolas, David B. Volkin, David D. Weis, Michael J. Rudolph, Yinghui Rong, David J. Vance
Publikováno v:
Proteins: Structure, Function, and Bioinformatics
In this report we investigated, within a group of closely related single domain camelid antibodies (VHHs), the relationship between binding affinity and neutralizing activity as it pertains to ricin, a fast-acting toxin and biothreat agent. The V1C7-
Autor:
Yue Hu, Sangeeta B. Joshi, Ronald T. Toth, David B. Volkin, C. Russell Middaugh, Reza Esfandiary, David D. Weis
Publikováno v:
Journal of pharmaceutical sciences. 109(1)
In this work, we continue to examine excipient effects on the reversible self-association (RSA) of 2 different IgG1 monoclonal antibodies (mAb-J and mAb-C). We characterize the RSA behavior of mAb-C which, similar to mAb-J (see Part 1), undergoes con
Autor:
C. Russell Middaugh, Nicholas J. Mantis, Siva Krishna Angalakurthi, Ronald T. Toth, Yuqi Shi, Dylan J. Ehrbar, David J. Vance, Greta Van Slyke, Yinghui Rong, David B. Volkin, David D. Weis
Publikováno v:
ImmunoHorizons. 2(8)
Ricin is a fast-acting protein toxin classified by the Centers for Disease Control and Prevention as a biothreat agent. In this report, we describe five new mouse mAbs directed against an immunodominant region, so-called epitope cluster II, on the su
Autor:
C. Russell Middaugh, Edwin Antony, Ronald T. Toth, Nicholas E. Dickenson, Heather B. Jones, Jamie L. Burgess, Prashant Kumar
Publikováno v:
Protein Science. 25:1037-1048
Gram-negative pathogens often use conserved type three secretion systems (T3SS) for virulence. The Shigella type three secretion apparatus (T3SA) penetrates the host cell membrane and provides a unidirectional conduit for injection of effectors into
Autor:
C. Russell Middaugh, Maarten L. van Roosmalen, Jae Hyun Kim, Wendy L. Picking, Ronald T. Toth, Prashant Kumar, Kees Leenhouts, William D. Picking, Shyamal P. Choudhari, Xiaotong Chen
Publikováno v:
Journal of Pharmaceutical Sciences. 104:4065-4073
Diarrhea caused by Shigella, Salmonella, and Yersinia is an important public health problem, but development of safe and effective vaccines against such diseases is challenging. A new antigen delivery platform called bacterium-like particles (BLPs) w
Autor:
Nicholas J. Mantis, David B. Volkin, Yinghui Rong, Greta Van Slyke, Siva Krishna Angalakurthi, Ronald T. Toth, Yuqi Shi, David D. Weis, David J. Vance, C. Russell Middaught, Dylan J. Ehrbar
Ricin is a fast-acting protein toxin classified by the Centers for Disease Control and Prevention as a biothreat agent. In this report we describe five new mouse monoclonal antibodies (mAbs) directed against an immunodominant region, so-called epitop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1bd9a4f0133008d993e9d3032e65e8