Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Ronald T Hay"'
Publikováno v:
PLoS Genetics, Vol 15, Iss 11, p e1008427 (2019)
Replication fork stalling and accumulation of single-stranded DNA trigger the S phase checkpoint, a signalling cascade that, in budding yeast, leads to the activation of the Rad53 kinase. Rad53 is essential in maintaining cell viability, but its targ
Externí odkaz:
https://doaj.org/article/48d5d5c5cb67477b9ee3b05d50d622d3
Autor:
Hianara A Bustamante, Karina Cereceda, Alexis E González, Guillermo E Valenzuela, Yorka Cheuquemilla, Sergio Hernández, Eloisa Arias-Muñoz, Cristóbal Cerda-Troncoso, Susanne Bandau, Andrea Soza, Gudrun Kausel, Bredford Kerr, Gonzalo A Mardones, Jorge Cancino, Ronald T Hay, Alejandro Rojas-Fernandez, Patricia V Burgos
Publikováno v:
Cells, Vol 9, Iss 3, p 777 (2020)
Ubiquitination regulates several biological processes, however the role of specific members of the ubiquitinome on intracellular membrane trafficking is not yet fully understood. Here, we search for ubiquitin-related genes implicated in protein membr
Externí odkaz:
https://doaj.org/article/3634f2aa74524a4e98b8cc55c16c1814
Autor:
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond
Publikováno v:
eLife, Vol 6 (2017)
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by
Externí odkaz:
https://doaj.org/article/5511bcb97c1940439d260bcc3a89f1d7
Autor:
Elizabeth Sloan, Michael H Tatham, Marine Groslambert, Mandy Glass, Anne Orr, Ronald T Hay, Roger D Everett
Publikováno v:
PLoS Pathogens, Vol 11, Iss 7, p e1005059 (2015)
Covalent linkage to members of the small ubiquitin-like (SUMO) family of proteins is an important mechanism by which the functions of many cellular proteins are regulated. Sumoylation has roles in the control of protein stability, activity and locali
Externí odkaz:
https://doaj.org/article/36e91925e46349f6badef79650c00cd6
Autor:
João Ferreira, Ronald T. Hay, Ellis Jaffray, José Rino, Inês Pinheiro, Joana Cardoso, Rafael Costa, Fernando Ferreira, Vera Santos, Marta Agostinho
Type 2 topoisomerases, in particular the α isoform in human cells, play a key role in cohesion and sister chromatid separation during mitosis. These enzymes are thus vital for cycling cells and are obvious targets in cancer chemotherapy. Evidence ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcab1efe70b422fe935943f78d98b59e
https://doi.org/10.1158/0008-5472.c.6497592
https://doi.org/10.1158/0008-5472.c.6497592
Autor:
João Ferreira, Ronald T. Hay, Ellis Jaffray, José Rino, Inês Pinheiro, Joana Cardoso, Rafael Costa, Fernando Ferreira, Vera Santos, Marta Agostinho
Supplementary Figure 1 from Conjugation of Human Topoisomerase 2α with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain Specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2018392bcef34187f7c2325b5133435c
https://doi.org/10.1158/0008-5472.22374813
https://doi.org/10.1158/0008-5472.22374813
Autor:
Arno F. Alpi, Ronald T. Hay, Gareth J. Inman, Amit Garg, Adel F.M. Ibrahim, Eilís Carroll, Craig MacKay
XLSX file - 196KB, Excel file with siRNA screen data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d93ba22ef08127b65059420acf0caa
https://doi.org/10.1158/0008-5472.22402478.v1
https://doi.org/10.1158/0008-5472.22402478.v1
Autor:
Arno F. Alpi, Ronald T. Hay, Gareth J. Inman, Amit Garg, Adel F.M. Ibrahim, Eilís Carroll, Craig MacKay
PDF file - 1462KB, Fig. S1: HOIP depletion results in cisplatin hypersensitivity. Fig. S2: HOIP depletion sensitizes cells to genotoxin-induced apoptotic cell death. Fig. S3: HEK293 cells stably expressing HA-IκBα S32A;S36A. Fig. S4: Boxplot analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a164d6b3452a2b9819add98cb91322
https://doi.org/10.1158/0008-5472.22402481
https://doi.org/10.1158/0008-5472.22402481
Autor:
João Ferreira, Ronald T. Hay, Ellis Jaffray, José Rino, Inês Pinheiro, Joana Cardoso, Rafael Costa, Fernando Ferreira, Vera Santos, Marta Agostinho
Supplementary Figure 1 Legend from Conjugation of Human Topoisomerase 2α with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain Specificity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bab2a4939213c094927a832dc2eda7c
https://doi.org/10.1158/0008-5472.22374816
https://doi.org/10.1158/0008-5472.22374816
Autor:
Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay
Publikováno v:
Journal of Cell Biology. 222
Acute Promyelocytic Leukemia is caused by expression of the oncogenic Promyelocytic Leukemia (PML)–Retinoic Acid Receptor Alpha (RARA) fusion protein. Therapy with arsenic trioxide results in degradation of PML-RARA and PML and cures the disease. M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b838c2b7933d353cf342d4404059e47
https://doi.org/10.1083/jcb.202201027
https://doi.org/10.1083/jcb.202201027