Výsledky vyhledávání - "Ronald T, Gansevoort"

Akademický článek

The STAGED-PKD 2-Stage Adaptive Study With a Patient Enrichment Strategy and Treatment Effect Modeling for Improved Study Design Efficiency in Patients With ADPKDPlain-Language Summary

Autor: Ronald D. Perrone, Ali Hariri, Pascal Minini, Curie Ahn, Arlene B. Chapman, Shigeo Horie, Bertrand Knebelmann, Michal Mrug, Albert C.M. Ong, York P.C. Pei, Vicente E. Torres, Vijay Modur, Ronald T. Gansevoort

Publikováno v: Kidney Medicine, Vol 4, Iss 10, Pp 100538- (2022)

Rationale & Objective: Venglustat, a glucosylceramide synthase inhibitor, inhibits cyst growth and reduces kidney failure in mouse models of autosomal dominant polycystic kidney disease (ADPKD). STAGED-PKD aims to determine the safety and efficacy of

Externí odkaz: https://doaj.org/article/66ff3b0e6417477da59ccf6a9cdbba1d

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Venglustat, a Novel Glucosylceramide Synthase Inhibitor, in Patients at Risk of Rapidly Progressing ADPKD: Primary Results of a Double-Blind, Placebo-Controlled, Phase 2/3 Randomized Clinical Trial

Autor: Ronald T, Gansevoort, Ali, Hariri, Pascal, Minini, Curie, Ahn, Arlene B, Chapman, Shigeo, Horie, Bertrand, Knebelmann, Michal, Mrug, Albert Cm, Ong, York Pc, Pei, Vicente E, Torres, Vijay, Modur, Igor, Antonshchuk, Ronald D, Perrone

Publikováno v: American Journal of Kidney Diseases, 81(5), 517-527.e1. W B SAUNDERS CO-ELSEVIER INC

Rationale & Objective: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple kidney cysts that leads to growth in total kidney volume (TKV) and progression to kidney failure. Venglustat is a glucosylcerami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124719c907294fe39ba73b86da5cc421
https://research.rug.nl/en/publications/2524f3fb-67b7-4b6a-84d7-08d0fa5f43ad

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Multiple Prior Live Births Are Associated With Cardiac Remodeling and Heart Failure Risk in Women

Publikováno v: JOURNAL OF CARDIAC FAILURE. Churchill Livingstone

Objective: Greater parity has been associated with cardiovascular disease risk. We sought to find whether the effects on cardiac remodeling and heart failure risk are clear.Methods: We examined the association of number of live births with echocardio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f329659e7ff757cd0e295a335b1ee2a
https://doi.org/10.1016/j.cardfail.2022.12.014

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Akademický článek

Serum Alkaline Phosphatase and Risk of Incident Cardiovascular Disease: Interrelationship with High Sensitivity C-Reactive Protein.

Autor: Setor K Kunutsor, Stephan J L Bakker, Jenny E Kootstra-Ros, Ronald T Gansevoort, John Gregson, Robin P F Dullaart

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132822 (2015)

Alkaline phosphatase (ALP) has been suggested to be associated with cardiovascular disease (CVD) risk, however, important aspects of the association, such as shape and independence from established risk factors, have yet to be characterized in detail

Externí odkaz: https://doaj.org/article/172e128d7af746da86dedc30da111760

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Akademický článek

Urinary vitamin D binding protein: a potential novel marker of renal interstitial inflammation and fibrosis.

Autor: Katarina Mirković, Carolina R C Doorenbos, Wendy A Dam, Hiddo J Lambers Heerspink, Maartje C J Slagman, Ferdau L Nauta, Andrea B Kramer, Ronald T Gansevoort, Jacob van den Born, Gerjan Navis, Martin H de Borst

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e55887 (2013)

Non-invasive tubulointerstitial damage markers may allow better titration and monitoring of renoprotective therapy. We investigated the value of urinary vitamin D binding protein excretion (uVDBP) as a tubulointerstitial inflammation and fibrosis mar

Externí odkaz: https://doaj.org/article/68c6f354370246a4b0432d0b83941842

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Gender differences in predictors of the decline of renal function in the general population

Autor: Nynke Halbesma, Auke H. Brantsma, Stephan J.L. Bakker, Desiree F. Jansen, Ronald P. Stolk, Dick De Zeeuw, Paul E. De Jong, Ronald T. Gansevoort, null for the PREVEND study group

Publikováno v: Kidney International, 74(4), 505-512. ELSEVIER SCIENCE INC

We sought to identify predictors of the decline in renal function, especially those that are modifiable, in the 5488 participants of the prospective, community-based cohort study PREVEND who completed three visits during a mean follow-up of 6.5 years

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6a1bfb37549b501c7bb7532170719dd
https://doi.org/10.1038/ki.2008.200

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Better understanding of ADPKD results in potential new treatment options: ready for the cure?

Autor: Esther, Meijer, Paul E, de Jong, Dorien J, Peters, Ronald T, Gansevoort

Publikováno v: Journal of nephrology. 21(2)

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common hereditary disorders. It accounts for 6% of the incidence of end-stage renal disease in Europe. Over the last decade, knowledge of the pathology underlying this disease ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d005cdfd1dec67596693dbdbeda16495
https://pubmed.ncbi.nlm.nih.gov/18446706

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