Výsledky vyhledávání - "Ronald Slomba"

Akademický článek

1040-A Leptin reprograms the macrophage response to inflammatory mediators: link between metabolism and immunity in obesity

Autor: Yali Zhang, Pawel Kalinski, Jianmin Wang, Sarbajit Mukherjee, Bowen Dong, Spencer Rosario, Adam Brinkman, Ronald Slomba

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/cad3b4a946b24e10898382e39276f6b0

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Abstract P4-06-07: Preliminary indications of safety and efficacy of neoadjuvant chemotherapy plus chemokine-modulating regimen (rintatolimod, IFN-α2b, celecoxib) in triple negative breast cancer

Autor: Shipra Gandhi, Mateusz Opyrchal, Cayla Ford, Ronald Slomba, Kristopher Attwood, Tracey O’Connor, Ellis Levine, Pawel Kalinski

Publikováno v: Cancer Research. 83:P4-06

BACKGROUND: Pathologic complete response (pCR) or microinvasive residual breast cancer (ypTmic) following neoadjuvant chemotherapy (NAC) is critical for good long-term outcomes in triple negative breast cancer (TNBC) patients (pts) but is achieved on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01a0cac9bc44c360a189fe1a8f72d69f
https://doi.org/10.1158/1538-7445.sabcs22-p4-06-07

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547 Safety and efficacy of de-escalated neoadjuvant chemoimmunotherapy of triple negative breast cancer (TNBC) using chemokine-modulating regimen (rintatolimod, IFN-α2b, celecoxib)

Autor: Shipra Gandhi, Mateusz Opyrchal, Cayla Ford, Ronald Slomba, Marie Quinn, Tracey O'Connor, Ellis Levine, Pawel Kalinski

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fd3e0177ac6b56d93c535299372aa86
https://doi.org/10.1136/jitc-2022-sitc2022.0547

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A randomized phase II trial of neoadjuvant chemokine modulation in patients with localized prostate cancer undergoing radical prostatectomy

Autor: Karan Jatwani, Bailey Farmer, Arya Mariam Roy, Ronald Slomba, Kristopher Attwood, Ellis Glenn Levine, Eric Kauffman, Pawel Kalinski, Khurshid Guru, Dharmesh Gopalakrishnan, Gurkamal S. Chatta

Publikováno v: Journal of Clinical Oncology. 41:TPS406-TPS406

TPS406 Background: Most patients with high or very high risk localized prostate cancer (PCa) experience disease recurrence after radical prostatectomy (RP). Neoadjuvant androgen ablation has not improved high-risk pathological features or recurrence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::714e015664c462ac0796f2bc1f01f260
https://doi.org/10.1200/jco.2023.41.6_suppl.tps406

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Abstract CT145: Systemic rintatolimod and interferon-α2b selectively reprogram local tumor microenvironment in patients with metastatic triple negative breast cancer for enhanced influx of cytotoxic T-lymphocytes but not regulatory T-cells

Autor: Shipra Gandhi, Mateusz Opyrchal, Melissa Grimm, Ronald Slomba, Kathleen Kokolus, Sebastiano Battaglia, Kristopher Attwood, Adrienne Groman, Lauren Williams, Mary Lynne Tarquini, Paul Wallace, Kah Teong Soh, Tracey O'Connor, Amy Early, Ellis Levine, Igor Puzanov, Marc Ernstoff, Pawel Kalinski

Publikováno v: Cancer Research. 82:CT145-CT145

Background: Effective immune therapies depend on the presence of cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment (TME). Our preclinical data showed synergy between TLR3 ligands and interferon-α (IFN-α) in reprogramming the TME, but not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71e6c6f2f177d9292527cdb790335176
https://doi.org/10.1158/1538-7445.am2022-ct145

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Abstract 3127: Negative impact of paclitaxel on human breast tumor microenvironment and its reversal by the combination of interferon-α with TLR3 agonist rintatolimod

Autor: Shipra Gandhi, Melissa Grimm, Ronald Slomba, Kazuaki Takabe, Pawel Kalinski

Publikováno v: Cancer Research. 82:3127-3127

Background: Taxanes are extensively used in the chemotherapy of breast cancer in the neoadjuvant, adjuvant and metastatic settings. Paclitaxel is known to have both immunostimulatory and immunosuppressive effects, but its impact on the chemokine syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d50ade6cb1ef5922c908188163a4fc08
https://doi.org/10.1158/1538-7445.am2022-3127

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Abstract CT105: Initial results of a phase II study evaluating a chemokine-modulatory (CKM) regimen in patients with colorectal cancer metastatic to the liver

Autor: Sarbajit Mukherjee, Patrick M. Boland, Melissa Grimm, Ronald Slomba, Kristopher Attwood, Renuka Iyer, Pawel Kalinski

Publikováno v: Cancer Research. 82:CT105-CT105

Background: Liver metastases develop in 20-50% of colorectal cancer (CRC) patients, being typically resistant to immune checkpoint inhibitors (ICIs) and having a poor prognosis. Our preliminary data showed synergy between IFNα and TLR3 ligands in se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8470e906b07ec073d6482db6c79eaaeb
https://doi.org/10.1158/1538-7445.am2022-ct105

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