Venous injection of a triphasic calcium-based implant in a sheep model of pulmonary embolism demonstrates minimal acute systemic effects

Autor: Caroline Constant, John D. Stroncek, Stephan Zeiter, Daniel Arens, Dirk Nehrbass, Dominic Gehweiler, Ursula Menzel, Lorin M. Benneker, Ronald S. Hill, Christoph E. Albers

Publikováno v: Constant, Caroline; Stroncek, John D; Zeiter, Stephan; Arens, Daniel; Nehrbass, Dirk; Gehweiler, Dominic; Menzel, Ursula; Benneker, Lorin M; Hill, Ronald S; Albers, Christoph E (2022). Venous injection of a triphasic calcium-based implant in a sheep model of pulmonary embolism demonstrates minimal acute systemic effects. European spine journal, 31(10), pp. 2812-2821. Springer 10.1007/s00586-022-07303-x

Purpose Implant leakage is the most common complication of vertebral augmentation. Alternative injectable materials must demonstrate intravascular safety comparable to or better than polymethyl methacrylate (PMMA). This study assessed the systemic ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e2899a17e258060af7c68184c2f980
https://pubmed.ncbi.nlm.nih.gov/35976438

In vitro injection of osteoporotic cadaveric femurs with a triphasic calcium‐based implant confers immediate biomechanical integrity

Autor: Dominique Favell, Jonathan L. Shaul, James G. Howe, Ronald S. Hill, Mary L. Bouxsein, Bryan Huber, John D. Stroncek

Publikováno v: Journal of Orthopaedic Research

Current pharmaceutical therapies can reduce hip fractures by up to 50%, but compliance to treatment is low and therapies take up to 18 months to reduce risk. Thus, alternative or complementary approaches to reduce the risk of hip fracture are needed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffe97a0c3696b0ac8019e31f43be669
https://doi.org/10.1002/jor.24239

Initial report of the use of an injectable porcine collagen-derived matrix to stimulate healing of diabetic foot wounds in humans

Autor: William A. Marston, Robert Mendes, Anton Usala, Mary‐Ann Minsley, Ronald S. Hill

Publikováno v: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 13(3)

A novel injectable scaffolding matrix (E-Matrix) has been developed to accelerate wound healing in diabetic foot ulcers. This porcine collagen-derived matrix is designed to mimic tertiary embryonic connective tissue and to stimulate fetal wound repai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e8c94e67991bbd81dd4261521e4a48
https://pubmed.ncbi.nlm.nih.gov/15953042

Increase in cAMP levels in beta-cell line potentiates insulin secretion without altering cytosolic free-calcium concentration

Autor: Ronald S. Hill, A. E. Boyd, James M Oberwetter

Publikováno v: Diabetes. 36(4)

With an SV40-transformed hamster β-cell line (HIT cells) as a model system, we tested the hypothesis that a rise in cAMP levels potentiates insulin release by an effect on the cytosolic free-Ca2+ concentration ([Ca2+])i. Intracellular cAMP levels we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf645618aa5b695257a4380e4fd3692
https://pubmed.ncbi.nlm.nih.gov/2434378

Effect of rise in cAMP levels on Ca2+ influx through voltage-dependent Ca2+ channels in HIT cells. Second-messenger synarchy in beta-cells

Autor: Arun S. Rajan, Ronald S. Hill, A. E. Boyd

Publikováno v: Diabetes. 38(7)

With a glucose-responsive (β-cell line (HIT cells), we tested the hypothesis that the cytosolic free Ca2+ level ([Ca2+],) is an intracellular signal through which a rise in cyclic AMP (cAMP) levels is transmitted to potentiate glucose-stimulated ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb81b04b017bf6e965ac189cbc27afc
https://pubmed.ncbi.nlm.nih.gov/2472299