Zobrazeno 1 - 10
of 439
pro vyhledávání: '"Ronald S, Duman"'
Publikováno v:
Neuropsychopharmacology Reports, Vol 44, Iss 1, Pp 246-249 (2024)
Abstract Vascular endothelial growth factor (VEGF) signaling is known to be involved in the antidepressant‐like effects of conventional antidepressants, such as desipramine (DMI), a tricyclic antidepressant, and fluoxetine (FLX), a selective seroto
Externí odkaz:
https://doaj.org/article/cc74544c92bd4e53b9bdb78a800dac3e
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Recent studies have implicated the endogenous opioid system in the antidepressant actions of ketamine, but the underlying mechanisms remain unclear. We used a combination of pharmacological, behavioral, and molecular approaches in rats to te
Externí odkaz:
https://doaj.org/article/afafdeb3c86749338da17daee958b2fe
Autor:
Janitza L. Montalvo-Ortiz, Joel Gelernter, Zhongshan Cheng, Matthew J. Girgenti, Ke Xu, Xinyu Zhang, Shyamalika Gopalan, Hang Zhou, Ronald S. Duman, Steven M. Southwick, John H. Krystal, Traumatic Stress Brain Research Study Group, Robert H. Pietrzak
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Posttraumatic stress disorder (PTSD) is a chronic and disabling psychiatric disorder prevalent in military veterans. Epigenetic mechanisms have been implicated in the etiology of PTSD, with DNA methylation being the most studied to identify
Externí odkaz:
https://doaj.org/article/9b03087f9a824d1cb85a96fc7bccecc2
Autor:
Avery D. Franzen, Tukiet T. Lam, Kenneth R. Williams, Angus C. Nairn, Ronald S. Duman, Monica Sathyanesan, Vikas Kumar, Linda L. Carpenter, Samuel S. Newton
Publikováno v:
BMC Psychiatry, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Depression affects approximately 7.1% of the United States population every year and has an annual economic burden of over $210 billion dollars. Several recent studies have sought to investigate the pathophysiology of depression u
Externí odkaz:
https://doaj.org/article/a114c8eade1c4e04a18a234e204ff3ee
Autor:
Shivani Bhatt, Ansel T. Hillmer, Matthew J. Girgenti, Aleksandra Rusowicz, Michael Kapinos, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Gustavo A. Angarita, Irina Esterlis, Margaret T. Davis, Steven M. Southwick, Matthew J. Friedman, Traumatic Stress Brain Study Group, Ronald S. Duman, Richard E. Carson, John H. Krystal, Robert H. Pietrzak, Kelly P. Cosgrove
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Neuroinflammation has been proposed to accompany the peripheral inflammation observed in PTSD. Here, authors find lower in vivo and postmortem levels of neuroimmune marker TSPO (translocator protein) in PTSD, in association with greater PTSD severity
Externí odkaz:
https://doaj.org/article/bb3f714c9295424b9a341b4b01971c9e
Autor:
Farhan Ali, Danielle M. Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S. Duman, Alex C. Kwan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The authors show that a subanesthetic dose of ketamine markedly elevate calcium signals in apical dendritic spines in the mouse prefrontal cortex. This effect is driven by a local-circuit mechanism that involves the suppression of somatostatin intern
Externí odkaz:
https://doaj.org/article/8227533bb0654c70a5cd7563059e67a7
Autor:
Sophie E. Holmes, Dustin Scheinost, Sjoerd J. Finnema, Mika Naganawa, Margaret T. Davis, Nicole DellaGioia, Nabeel Nabulsi, David Matuskey, Gustavo A. Angarita, Robert H. Pietrzak, Ronald S. Duman, Gerard Sanacora, John H. Krystal, Richard E. Carson, Irina Esterlis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Lowered synaptic density is believed to occur in major depressive disorder and PTSD, possibly as an effect of stress. Here, the authors use positron emission tomography (PET) to measure levels of the synaptic marker SV2A and show that SV2A density is
Externí odkaz:
https://doaj.org/article/16df126356f84726bd48b72d3e90f6bf
Autor:
Brendan D. Hare, Ryota Shinohara, Rong Jian Liu, Santosh Pothula, Ralph J. DiLeone, Ronald S. Duman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Ketamine exerts fast-acting anti-depressant responses. Here the authors show that dopamine D1 receptor expressing neurons in the medial prefrontal cortex contribute to these antidepressant-like effects in mice.
Externí odkaz:
https://doaj.org/article/2d3337a5795543eab74014329bf3aa23
Autor:
Minal Jaggar, Shreya Ghosh, Balaganesh Janakiraman, Ashmita Chatterjee, Megha Maheshwari, Vani Dewan, Brendan Hare, Sukrita Deb, Dwight Figueiredo, Ronald S Duman, Vidita A Vaidya
Publikováno v:
International Journal of Neuropsychopharmacology. 26:294-306
Background Electroconvulsive seizure therapy is often used in both treatment-resistant and geriatric depression. However, preclinical studies identifying targets of chronic electroconvulsive seizure (ECS) are predominantly focused on animal models in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09849802867bc6055a08a6bbe73cf536
https://doi.org/10.1093/ijnp/pyad008
https://doi.org/10.1093/ijnp/pyad008
Autor:
Sriparna Ghosal, Catharine H. Duman, Rong-Jian Liu, Min Wu, Rosemarie Terwilliger, Matthew J. Girgenti, Eric Wohleb, Manoela V. Fogaca, Emily M. Teichman, Brendan Hare, Ronald S. Duman
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Dysfunction of medial prefrontal cortex (mPFC) in association with imbalance of inhibitory and excitatory neurotransmission has been implicated in depression. However, the precise cellular mechanisms underlying this imbalance, particularly for GABAer
Externí odkaz:
https://doaj.org/article/ddd4cb39631a4c748e757426ea0a3eb8