Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ronald Pachon"'
Autor:
Antanina Voit, Vishwendra Patel, Ronald Pachon, Vikas Shah, Mohammad Bakhutma, Erik Kohlbrenner, Joseph J. McArdle, Louis J. Dell’Italia, Jerry R. Mendell, Lai-Hua Xie, Roger J. Hajjar, Dongsheng Duan, Diego Fraidenraich, Gopal J. Babu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Sarcolipin is an inhibitor of the ATP dependent calcium pump SERCA, and is abnormally elevated in Duchenne muscular dystrophy. The authors show that reducing sarcolipin expression ameliorates skeletal muscle pathology and cardiomyopathy and extends l
Externí odkaz:
https://doaj.org/article/201501e20c1241caab7a1010c329171a
Autor:
Mayilvahanan Shanmugam, Dan Li, Shumin Gao, Nadezhda Fefelova, Vikas Shah, Antanina Voit, Ronald Pachon, Ghassan Yehia, Lai-Hua Xie, Gopal J Babu
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115822 (2015)
The functional importance of threonine 5 (T5) in modulating the activity of sarcolipin (SLN), a key regulator of sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) pump was studied using a transgenic mouse model with cardiac specific expression of
Externí odkaz:
https://doaj.org/article/f2b99dd49fc14ef38a9468a7d16d1691
Autor:
Rekha Balakrishnan, Nadezhda Fefelova, Gopal J. Babu, Lai-Hua Xie, Ronald Pachon, Jayapalraj Thilagavathi, Satvik Mareedu, Nandita Niranjan
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H200-H210
Sarcolipin (SLN) is an inhibitor of sarco/endoplasmic reticulum (SR) Ca2+-ATPase (SERCA) and expressed at high levels in the ventricles of animal models for and patients with Duchenne muscular dystrophy (DMD). The goal of this study was to determine
Autor:
Satvik, Mareedu, Ronald, Pachon, Jayapalraj, Thilagavathi, Nadezhda, Fefelova, Rekha, Balakrishnan, Nandita, Niranjan, Lai-Hua, Xie, Gopal J, Babu
Publikováno v:
Am J Physiol Heart Circ Physiol
Sarcolipin (SLN) is an inhibitor of sarco/endoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA) and expressed at high levels in the ventricles of animal models for and patients with Duchenne muscular dystrophy (DMD). The goal of this study was to determin
Autor:
Daniella M. Beniamen, Xin Zhao, Poornima Balaji, Ronald Pachon, Stephen F. Vatner, Dorothy E. Vatner, Robert M. Graham
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35:2451-2459
Objective— Stimulation of cardiac α 1A -adrenergic receptors (α 1A -AR) has been proposed for treatment of heart failure, since it increases myocardial contractility. We investigated a different mechanism, induction of angiogenesis. Approach and
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2015 (2015)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Mice with disruption of adenylyl cyclase type 5 (AC5 knockout, KO) live a third longer than littermates. The mechanism, in part, involves the MEK/ERK pathway, which in turn is related to protection against oxidative stress. The AC5 KO model also prot
Autor:
Louis J. Dell'Italia, Antanina Voit, Vishwendra Patel, Dongsheng Duan, Joseph J. McArdle, Ronald Pachon, Lai-Hua Xie, Erik Kohlbrenner, Jerry R. Mendell, Gopal J. Babu, Mohammad Bakhutma, Vikas Shah, Diego Fraidenraich, Roger J. Hajjar
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Sarcolipin (SLN) is an inhibitor of the sarco/endoplasmic reticulum (SR) Ca2+ ATPase (SERCA) and is abnormally elevated in the muscle of Duchenne muscular dystrophy (DMD) patients and animal models. Here we show that reducing SLN levels ameliorates d
Autor:
Romina Torres-Robles, Miguel A Alvarez, Stuart Zarich, Marcela Rivera‐Cornejo, Carlos M Rondon Clavo, Claudio Bravo, Patricio Oliva, Ronald Pachon, Gabriel Rada
Publikováno v:
The Cochrane Library
Reason for withdrawal from publication This protocol is being withdrawn because authors have decided not to continue.
A Food and Drug Administration-approved antiviral agent, known as vidarabine or adenine 9-β-D-arabinofuranoside (AraA), has features of inhibiting adenylyl cyclase type 5 (AC5) and protects against chronic coronary artery occlusion (CAO). The goal o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc428a35d080c11b6b79a0d8634d76d
https://europepmc.org/articles/PMC4851318/
https://europepmc.org/articles/PMC4851318/
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 309(12)
reply: The letter by Zuurbier et al. ([8][1]) questions one of the conclusions in our recently published article ([5][2]), that ketamine alone, at a dose of 150 mg/kg, was the best anesthetic for echocardiography. Zuurbier et al. noted that they were