Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ronald P.A. Gaykema"'
Publikováno v:
Journal of Visualized Experiments.
It was discovered that electrical kindling of VGAT-Cre mice led to the spontaneous motor and electrographic seizures. A recent paper focused on how unique VGAT-Cre mice were used in developing spontaneous recurring seizures (SRS) after kindling and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cdd9dfab0ca2c1f8030d76ec23aeea3
https://doi.org/10.3791/62929-v
https://doi.org/10.3791/62929-v
DNA Methyltransferase 1 and 3a Expression in the Frontal Cortex Regulates Palatable Food Consumption
Autor:
Eric R. Wengert, Amelie Kuchler, Anusha U. Saga, Daniel M. Warthen, Michael Scott, Manoj K. Patel, Mohan C. Manjegowda, Jonathan Joy-Gaba, Ronald P.A. Gaykema, Nathan C. Sheffield
DNA methylation is an important regulatory mechanism in the control of neuronal function. Both during development and following exposure to salient stimuli, plasticity in the methylation of cytosine residues leads to a change in neuron excitability t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e0e55766680f454358ae84d60b31e6
https://doi.org/10.1101/2021.05.23.445176
https://doi.org/10.1101/2021.05.23.445176
Autor:
Cody J. Smith, Bryan S. Barker, Christopher D. Deppmann, Matteo Ottolini, Sarah Kucenas, Manoj K. Patel, Ryan M. Grippo, Ali D. Güler, Michael A. Wheeler, Anthony J. Spano, Ronald P.A. Gaykema, Mark P. Beenhakker, Aarti M. Purohit
Publikováno v:
Nature Neuroscience. 19:756-761
Optogenetic and chemogenetic actuators are critical for deconstructing the neural correlates of behavior. However, these tools have several limitations, including invasive modes of stimulation or slow on/off kinetics. We have overcome these disadvant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::397afa68aae0d91543202d92f6712490
https://doi.org/10.1038/nn.4265
https://doi.org/10.1038/nn.4265
Autor:
Hannah M. Bacon, Manoj K. Patel, Brant E. Isakson, Tyler Johnson, Miranda E. Good, Zhiyi Zuo, Ronald P.A. Gaykema, Susan M. Lang, Joshua T. Butcher, Jun Li, Stephanie A. Eucker
Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function and patholog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fbe379a496a6c85aaa2dba366f9d98c
https://europepmc.org/articles/PMC5926909/
https://europepmc.org/articles/PMC5926909/
Autor:
Janet E. Lewis, Tamara G Fischer-White, Katharine E. Adelstein, Michael Scott, Maheswari Murugesan, Lisa E. Goehler, Joel G. Anderson, Ronald P.A. Gaykema, Ann Gill Taylor
Publikováno v:
Stress and Health. 32:503-513
The possibility that immunological changes might contribute to symptom severity in fibromyalgia (FM) prompted this proof-of-concept study to determine whether differences in monocyte subpopulations might be present in persons with FM compared with he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46ae091e88afcd43477b42cbdbb18ebe
https://doi.org/10.1002/smi.2648
https://doi.org/10.1002/smi.2648
SCN8A encephalopathy, or early infantile epileptic encephalopathy 13 (EIEE13), is caused predominantly by de novo gain-of-function mutations in the voltage-gated Na channel Nav1.6. Affected individuals suffer from refractory seizures, developmental d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53537292f1da79c29f129bdadb582fad
https://europepmc.org/articles/PMC5551062/
https://europepmc.org/articles/PMC5551062/
Autor:
Bryan S. Barker, Edward Perez-Reyes, Manoj K. Patel, Michael Scott, Ronald P.A. Gaykema, Brandon A. Newmyer, Matteo Ottolini, Daniel M. Warthen, Philip S. Lambeth, Ali D. Güler, Yu Ohmura, Yingtang Shi, Jonathan Joy-Gaba
Publikováno v:
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
Frontiers in Behavioral Neuroscience, Vol 10 (2016)
The medial prefrontal cortex (mPFC) is involved in a wide range of executive cognitive functions, including reward evaluation, decision-making, memory extinction, mood, and task switching. Manipulation of the mPFC has been shown to alter food intake
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0666fdbf4188a80bb925c76725ff9802
https://doi.org/10.3389/fnbeh.2016.00063
https://doi.org/10.3389/fnbeh.2016.00063
Autor:
Lisa E. Goehler, Ronald P.A. Gaykema
Publikováno v:
Brain, Behavior, and Immunity. 25:443-460
Immune challenges can lead to marked behavioral changes, including fatigue, reduced social interest, anorexia, and somnolence, but the precise neuronal mechanisms that underlie sickness behavior remain elusive. Part of the neurocircuitry influencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3590f283a7b40c0b33aa70fd421ff3fe
https://doi.org/10.1016/j.bbi.2010.11.005
https://doi.org/10.1016/j.bbi.2010.11.005
Publikováno v:
Brain, Behavior, and Immunity. 22:1160-1172
Immune challenge induces behavioral changes including reduced ingestion of palatable food. Multiple pathways likely contribute to this effect, including viscerosensory pathways controlling hypothalamic feeding circuits or by influence on "reward" cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ab2bd8345fdba8827caf255181aba6
https://doi.org/10.1016/j.bbi.2008.05.001
https://doi.org/10.1016/j.bbi.2008.05.001
Publikováno v:
Brain, Behavior, and Immunity. 22:354-366
The presence of certain bacteria in the gastrointestinal tract influences behavior and brain function. For example, challenge with live Campylobacter jejuni (C. jejuni), a common food-born pathogen, reduces exploration of open arms of the plus maze,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b526137d1508e57cfb3986e35d16e15
https://doi.org/10.1016/j.bbi.2007.08.009
https://doi.org/10.1016/j.bbi.2007.08.009