Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ronald P. Jean"'
Publikováno v:
Journal of Biomechanical Engineering. 126:552-558
We investigated the mechanotransduction pathway in endothelial cells between their nucleus and adhesions to the extracellular matrix. First, we measured nuclear deformations in response to alterations of cell shape as cells detach from a flat surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996f0d570da56f79255f29d8ce48282a
https://doi.org/10.1115/1.1800559
https://doi.org/10.1115/1.1800559
Autor:
Alexander A. Spector, Ronald P. Jean
Publikováno v:
Experimental Mechanics. 43:355-360
The outer hair cell is a specialized cell in the mammalian cochlea, believed to amplify incoming sound waves. This amplification is associated with the outer hair cell's electromotility, a unique cellular phenomenon of voltage-dependent length change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c908d36ac88a838a8daec1eb03a4676b
https://doi.org/10.1007/bf02410535
https://doi.org/10.1007/bf02410535
Publikováno v:
Journal of biomechanical engineering. 127(4)
Endothelial cells possess a mechanical network connecting adhesions on the basal surface, the cytoskeleton, and the nucleus. Transmission of force at adhesions via this pathway can deform the nucleus, ultimately resulting in an alteration of gene exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fffe4d08958e43e9100850bf097b19a
https://pubmed.ncbi.nlm.nih.gov/16121529
https://pubmed.ncbi.nlm.nih.gov/16121529
Autor:
Celeste M. Nelson, Nathan J. Sniadecki, Wendy Liu, John L. Tan, Christopher S. Chen, Ronald P. Jean, Alexander A. Spector
Publikováno v:
Nelson, CM; Jean, RP; Tan, JL; Liu, WF; Sniadecki, NJ; Spector, AA; et al.(2005). Emergent patterns of growth controlled by multicellular form and mechanics. Proceedings of the National Academy of Sciences, 102(33), 11594-11599. doi: 10.1073/pnas.0502575102. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4cd2h5nj
Spatial patterns of cellular growth generate mechanical stresses that help to push, fold, expand, and deform tissues into their specific forms. Genetic factors are thought to specify patterns of growth and other behaviors to drive morphogenesis. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d982c01234de5cc1c3ee65529f62024
http://www.escholarship.org/uc/item/4cd2h5nj
http://www.escholarship.org/uc/item/4cd2h5nj
Autor:
Alexander A. Spector, Ronald P. Jean
Publikováno v:
Journal of biomechanical engineering. 126(1)
Here, we analyze energy transformations in the outer hair cell and its effectiveness as a piezoelectric-type actuator in the cochlea. The major modes of energy are introduced, and a method to estimate the coefficients of their tension-dependence is p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57a8f43679f25f3bbc5105e537029ba
https://pubmed.ncbi.nlm.nih.gov/15171125
https://pubmed.ncbi.nlm.nih.gov/15171125
Autor:
Ronald P. Jean, Alexander A. Spector
Publikováno v:
Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.
The cochlear outer hair cell is unique in that it can produce voltage-dependent length changes (electromotility). This aspect of the outer hair cell makes it a potential candidate for cochlear amplification. We model the outer hair cell with piezoele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe375b157f2a4e85662f14adc9ce0db3
https://doi.org/10.1109/iembs.2002.1136848
https://doi.org/10.1109/iembs.2002.1136848
Publikováno v:
Advances in Bioengineering.
The area of cell spreading has been proven to be critical to a cell’s fate, and direct physical connections between integrins, cytoskeleton, and the nucleus have been found [1]. We investigate the cell adhesion-cytoskeleton-nucleus mechanical pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cb279b771dafa795bc407f42936876f
https://doi.org/10.1115/imece2003-42905
https://doi.org/10.1115/imece2003-42905