Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ronald P J, Oude Elferink"'
Publikováno v:
Frontiers in Medicine, Vol 8 (2021)
Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial intrahepatic cholestasis (PFIC). The molecular mechanisms leadin
Externí odkaz:
https://doaj.org/article/5d5c752cb45f4e04a1657c0472d7a4d4
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 20:26-36
Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the quality of life of those affected. Here, we provide an update on the latest insights into the molecular pathogenesis of and novel therapeutic approaches for chol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6243d3a6617073b0eec10adc814caba4
https://doi.org/10.1038/s41575-022-00687-7
https://doi.org/10.1038/s41575-022-00687-7
Autor:
Kim N. van Munster, Marcel G. W. Dijkgraaf, Ronald P. J. Oude Elferink, Ulrich Beuers, Cyriel Y. Ponsioen
Publikováno v:
Liver international, 42(7), 1562-1570. Wiley-Blackwell
Background & Aims: Patients with primary sclerosing cholangitis (PSC) may suffer from complaints such as pruritus, right upper abdominal quadrant pain (RUQ-A) and fatigue. However, the severity of these complaints, daily and/or seasonal patterns and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a43bea08ede6600aa8cf0eb29a4be98
https://doi.org/10.1111/liv.15271
https://doi.org/10.1111/liv.15271
Autor:
Danielle Straub, Ronald P J Oude Elferink, Peter L M Jansen, Jacques J G H M Bergman, Kaushal Parikh, Kausilia K Krishnadath
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0220050 (2019)
Bile acid reflux is known to be associated with the development of Barrett's esophagus and esophageal adenocarcinoma (EAC), yet the role of specific bile acids and the mechanism behind the metaplastic changes is unclear. Here, we demonstrate that mul
Externí odkaz:
https://doaj.org/article/acd7f0cd2eb649c89c02c6f30e3f225d
Autor:
Aziza A A Adam, Vincent A van der Mark, Joanne M Donkers, Manon E Wildenberg, Ronald P J Oude Elferink, Robert A F M Chamuleau, Ruurdtje Hoekstra
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0193664 (2018)
Practice-changing culturing techniques of hepatocytes are highly required to increase their differentiation. Previously, we found that human liver cell lines HepaRG and C3A acquire higher functionality and increased mitochondrial biogenesis when cult
Externí odkaz:
https://doaj.org/article/dda135b9f4ac477fa76ca8c842d09a26
Autor:
Valentina E. Gómez‐Mellado, Kam S. Ho‐Mok, Vincent A. van der Mark, Nicole N. van der Wel, Anita E. Grootemaat, Arthur J. Verhoeven, Ronald P. J. Oude Elferink, Coen C. Paulusma
Publikováno v:
Cell biochemistry and function, 40(8), 914-925. John Wiley and Sons Ltd
ATP8B1 is a phospholipid flippase and member of the type 4 subfamily of P-type ATPases (P4-ATPase) subfamily. P4-ATPases catalyze the translocation of phospholipids across biological membranes, ensuring proper membrane asymmetry, which is crucial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6718e76b182e309b25e34c88ca5237
https://pure.amc.nl/en/publications/the-phospholipid-flippase-atp8b1-is-required-for-lysosomal-fusion-in-macrophages(293a2a2e-b98a-421e-8b68-e7ef0f2e634a).html
https://pure.amc.nl/en/publications/the-phospholipid-flippase-atp8b1-is-required-for-lysosomal-fusion-in-macrophages(293a2a2e-b98a-421e-8b68-e7ef0f2e634a).html
Autor:
Charles M.G. Frijters, Coosje J. Tuijn, Roelof Ottenhoff, Bart N. Zegers, Albert K. Groen, Ronald P. J. Oude Elferink
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 1950-1957 (1999)
Class III P-glycoproteins (Pgps) mediate biliary phosphatidylcholine (PC) secretion. Recent findings that class I P-glycoproteins are able to transport several short-chain phospholipid analogues raises questions about the role of these Pgps in physio
Externí odkaz:
https://doaj.org/article/2b9a8f3e1f6d472bbde2f30ccc734fc2
Autor:
Jung-Chin, Chang, Simei, Go, Eduardo H, Gilglioni, Suzanne, Duijst, Daan M, Panneman, Richard J, Rodenburg, Hang Lam, Li, Hsu-Li, Huang, Lonny R, Levin, Jochen, Buck, Arthur J, Verhoeven, Ronald P J, Oude Elferink
Publikováno v:
Biochimica et biophysica acta. Bioenergetics. 1862(4)
The evolutionarily conserved soluble adenylyl cyclase (sAC, ADCY10) mediates cAMP signaling exclusively in intracellular compartments. Because sAC activity is sensitive to local concentrations of ATP, bicarbonate, and free Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c0514ed7dbb77991170b0a7a0d0d02d7
https://pubmed.ncbi.nlm.nih.gov/33412125
https://pubmed.ncbi.nlm.nih.gov/33412125
Autor:
Geert A A Nibourg, Robert A F M Chamuleau, Tessa V van der Hoeven, Martinus A W Maas, An F C Ruiter, Wouter H Lamers, Ronald P J Oude Elferink, Thomas M van Gulik, Ruurdtje Hoekstra
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38778 (2012)
A major roadblock to the application of bioartificial livers is the need for a human liver cell line that displays a high and broad level of hepatic functionality. The human bipotent liver progenitor cell line HepaRG is a promising candidate in this
Externí odkaz:
https://doaj.org/article/6c1861603e0d4671ab5f49e67411a5eb
Autor:
Sohela Shah, Ukina R Sanford, Julie C Vargas, Hongmei Xu, Annamiek Groen, Coen C Paulusma, James P Grenert, Ludmila Pawlikowska, Saunak Sen, Ronald P J Oude Elferink, Laura N Bull
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e8984 (2010)
Mutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as a
Externí odkaz:
https://doaj.org/article/f61eb41a938d4360947de57a5abcf7f3