Zobrazeno 1 - 10
of 399
pro vyhledávání: '"Ronald N Germain"'
Autor:
Chen Zhao, Ronald N Germain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 10 (2023)
Multiplex imaging has emerged as an invaluable tool for immune-oncologists and translational researchers, enabling them to examine intricate interactions among immune cells, stroma, matrix, and malignant cells within the tumor microenvironment (TME).
Externí odkaz:
https://doaj.org/article/77be350f07af463da3d1dde7c5b78dba
Autor:
Arun Rajan, Qiang Dong, Chen Zhao, Abigail Wong-Rolle, Prajan Divakar, Yunhua Zhu, Jyh Liang Hor, Noemi Kedei, Madeline Wong, Desiree Tillo, Elizabeth A Conner, David S Schrump, Chengcheng Jin, Ronald N Germain
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background The lung intratumor microbiome influences lung cancer tumorigenesis and treatment responses, but detailed data on the extent, location, and effects of microbes within lung tumors are missing, information needed for improved prognosis and t
Externí odkaz:
https://doaj.org/article/47f6a90d8eef421d919e4a0c79821c52
Autor:
Emilie V Russler-Germain, Jaeu Yi, Shannon Young, Katherine Nutsch, Harikesh S Wong, Teresa L Ai, Jiani N Chai, Vivek Durai, Daniel H Kaplan, Ronald N Germain, Kenneth M Murphy, Chyi-Song Hsieh
Publikováno v:
eLife, Vol 10 (2021)
Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103+ gut dendritic cells (DCs), yet their role in commensal-reactive pTreg development is unclear. Using two Helicobacter-specific T cell receptor (TCR)
Externí odkaz:
https://doaj.org/article/007c449ec2de46e180b76c8533b9af29
Autor:
Rachel A Gottschalk, Michael G Dorrington, Bhaskar Dutta, Kathleen S Krauss, Andrew J Martins, Stefan Uderhardt, Waipan Chan, John S Tsang, Parizad Torabi-Parizi, Iain DC Fraser, Ronald N Germain
Publikováno v:
eLife, Vol 8 (2019)
Despite existing evidence for tuning of innate immunity to different classes of bacteria, the molecular mechanisms used by macrophages to tailor inflammatory responses to specific pathogens remain incompletely defined. By stimulating mouse macrophage
Externí odkaz:
https://doaj.org/article/fdc88cf2aeb74de0b9da323df06719f1
Autor:
Andrea J Radtke, Wolfgang Kastenmüller, Diego A Espinosa, Michael Y Gerner, Sze-Wah Tse, Photini Sinnis, Ronald N Germain, Fidel P Zavala, Ian A Cockburn
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004637 (2015)
Malaria infection begins when a female Anopheles mosquito injects Plasmodium sporozoites into the skin of its host during blood feeding. Skin-deposited sporozoites may enter the bloodstream and infect the liver, reside and develop in the skin, or mig
Externí odkaz:
https://doaj.org/article/fc456f521ca44b5994215478590319b0
Autor:
Renata I Mazzucchelli, Søren Warming, Scott M Lawrence, Masaru Ishii, Mehrnoosh Abshari, A Valance Washington, Lionel Feigenbaum, Andrew C Warner, Davis J Sims, Wen Qing Li, Julie A Hixon, Daniel H D Gray, Benjamin E Rich, Matthew Morrow, Miriam R Anver, James Cherry, Dieter Naf, Lawrence R Sternberg, Daniel W McVicar, Andrew G Farr, Ronald N Germain, Keith Rogers, Nancy A Jenkins, Neal G Copeland, Scott K Durum
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7637 (2009)
Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial chromosome (BAC) transgenic mouse expressing ECFP in the I
Externí odkaz:
https://doaj.org/article/97899add48644baaaae8623b3d0db253
Autor:
Martin Meier-Schellersheim, Xuehua Xu, Bastian Angermann, Eric J Kunkel, Tian Jin, Ronald N Germain
Publikováno v:
PLoS Computational Biology, Vol 2, Iss 7, p e82 (2006)
The signaling network underlying eukaryotic chemosensing is a complex combination of receptor-mediated transmembrane signals, lipid modifications, protein translocations, and differential activation/deactivation of membrane-bound and cytosolic compon
Externí odkaz:
https://doaj.org/article/4673e3c3fb60497993dfc973044e8321
Publikováno v:
PLoS Biology, Vol 3, Iss 11, p e356 (2005)
T-lymphocyte activation displays a remarkable combination of speed, sensitivity, and discrimination in response to peptide-major histocompatibility complex (pMHC) ligand engagement of clonally distributed antigen receptors (T cell receptors or TCRs).
Externí odkaz:
https://doaj.org/article/d114edfb1d8a488aa10dc7400ad82b37
Autor:
Anna Kuchina, Jason Yang, Bree Aldridge, Kevin A. Janes, Naeha Subramanian, Nevan J. Krogan, Mehdi Bouhaddou, Shirit Einav, Jason Papin, Ronald N. Germain
Publikováno v:
Cell Systems. 13:945-949
Leading researchers at the intersection of infectious disease and systems biology speak about how systems approaches have influenced modern infectious disease research and what these tools can offer for the future of the field.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37108d5b0bfa42c4740f342e9e654a5
https://doi.org/10.1016/j.cels.2022.11.009
https://doi.org/10.1016/j.cels.2022.11.009
Autor:
Vivien Maltez, Charu Arora, Rina Sor, Qiaoshi Lian, Robert H. Vonderheide, Ronald N. Germain, Katelyn T. Byrne
Multiple cell types, molecules, and processes contribute to inhibition of anti-tumor effector responses, often frustrating effective immunotherapy. Among these, Foxp3+ CD4+ cells (Tregs) are well-recognized to play an immunosuppressive role in the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecbeb48347829b9f58366364f0e01c66
https://doi.org/10.1101/2022.10.17.512537
https://doi.org/10.1101/2022.10.17.512537
