Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ronald Mays"'
Autor:
Soongyu Choi, Zhonghua Zhang, Gan Wang, Anish Konkar, Su-Ellen Brown, Susan Tomlinson, Roger A. Smith, Ning Su, Theresa Tritto, Astrid A. Ortiz, Stephan-Nicholas Wirtz, Ronald Mays, Jennifer Natoli, Christiana Akuche, Stephen J. O’Connor, Wong Wai C, Christy Taing, Rico Lavoie, Zahra Fathi, Shihong Ying, Jianmei Fan, Susan Jenkins, Harold C. E. Kluender, Furahi Achebe, Xiao-Fan Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2706-2711
Several imidazole-based cyclohexyl amides were identified as potent CB-1 antagonists, but they exhibited poor oral exposure in rodents. Incorporation of a hydroxyl moiety on the cyclohexyl ring provided a dramatic improvement in oral exposure, togeth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6d8a5abbce76408ea8e7ec42b5b760
https://doi.org/10.1016/j.bmcl.2007.03.011
https://doi.org/10.1016/j.bmcl.2007.03.011
Autor:
Jianmei Fan, Ronald Mays, Anish Konkar, Zhonghua Zhang, Roger A. Smith, Susan Jenkins, Harold C. E. Kluender, Su-Ellen Brown, Christy Taing, Brent Podlogar, Theresa Tritto, Jennifer Natoli, Soongyu Choi, Astrid A. Ortiz, Susan Tomlinson, Stephen J. O’Connor, Rico Lavoie, Zahra Fathi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:673-678
A series of pyrrolopyridinones was designed and synthesized as constrained analogs of the pyrazole CB-1 antagonist rimonabant. Certain examples exhibited very potent hCB-1 receptor binding affinity and functional antagonism with K i and K b values be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25b875b3febc28fc1ac054800a38f00
https://doi.org/10.1016/j.bmcl.2006.10.095
https://doi.org/10.1016/j.bmcl.2006.10.095