Výsledky vyhledávání - "Ronald Mathieu"

High-quality nuclei isolation from postmortem human heart muscle tissues for single-cell studies

Autor: Sarah Araten, Ronald Mathieu, Anushka Jetly, Hoon Shin, Nazia Hilal, Bo Zhang, Katherine Morillo, Deepa Nandan, Indu Sivankutty, Ming Hui Chen, Sangita Choudhury

Publikováno v: Journal of Molecular and Cellular Cardiology. 179:7-17

Single-cell approaches have become an increasingly popular way of understanding the genetic factors behind disease. Isolation of DNA and RNA from human tissues is necessary to analyze multi-omic data sets, providing information on the single-cell gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ebc7cb39650ec368a2c4e029683d7b
https://doi.org/10.1016/j.yjmcc.2023.03.010

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The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia

Autor: Patricia Sousa, Trista E. North, Ronald Mathieu, Pavlos Missios, R. Grant Rowe, Michael A. Morse, George Q. Daley, Edroaldo Lummertz da Rocha, Alena Yermalovich, Deepak Kumar Jha, Mark D. Fleming, William Marion, Jessica Barragan

Publikováno v: Journal of Experimental Medicine. 216:527-538

Leukemia phenotypes vary with age of onset. Delineating mechanisms of age specificity in leukemia could improve disease models and uncover new therapeutic approaches. Here, we used heterochronic transplantation of leukemia driven by MLL/KMT2A translo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d854716a52e6fafa8337c05274d1251f
https://doi.org/10.1084/jem.20181765

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Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis

Autor: R. Grant Rowe, Amy J. Wagers, Samantha J. Ross, Leo D. Wang, George Q. Daley, Silvia Coma, Ronald Mathieu, Phi T. Nguyen, Patricia Sousa, Areum Han, Antony Rodriguez, Daniel S. Pearson

Publikováno v: The Journal of Experimental Medicine

Daley and collaborators show that endogenous Lin28b drives erythroid-dominant fetal hematopoiesis and that decreases in Lin28b activate adult granulocyte-predominant hematopoiesis.
For appropriate development, tissue and organ system morphogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3935fb87bb27725e4d7b52391e7a7a9d
https://doi.org/10.1084/jem.20151912

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Next-Generation Sequencing Reveals Restriction and Clonotypic Expansion of Treg Cells in Juvenile Idiopathic Arthritis

Autor: Stefano Volpi, David Zurakowski, Francesco Frugoni, Susan Kim, Jolan E. Walter, Neng Yu, Lauren A. Henderson, Mary Beth F. Son, Ronald Mathieu, Tatiana Lebedeva, Luigi D. Notarangelo, Fatma Dedeoglu, Mindy S. Lo, Robert P. Sundel, Yu Nee Lee, Peter A. Nigrovic, Melissa M. Hazen, Erin Janssen, Robert C. Fuhlbrigge

Publikováno v: Arthritis & Rheumatology. 68:1758-1768

Objective Treg cell-mediated suppression of Teff cells is impaired in juvenile idiopathic arthritis (JIA); however, the basis for this dysfunction is incompletely understood. Animal models of autoimmunity and immunodeficiency demonstrate that a diver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6bd2ec0e9a79abd5d1040989478e22
https://doi.org/10.1002/art.39606

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The developmental stage of the hematopoietic niche regulates lineage in

Autor: R Grant, Rowe, Edroaldo, Lummertz da Rocha, Patricia, Sousa, Pavlos, Missios, Michael, Morse, William, Marion, Alena, Yermalovich, Jessica, Barragan, Ronald, Mathieu, Deepak Kumar, Jha, Mark D, Fleming, Trista E, North, George Q, Daley

Publikováno v: The Journal of Experimental Medicine

Rowe and colleagues show that hematopoietic cells with MLL translocations undergoing leukemogenesis in neonatal mice yield mixed-lineage early B-lymphoid/myeloid leukemia while identical cells in adults generate myeloid leukemia, demonstrating that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::857386d096eb7cc9084df558fdae9488
https://pubmed.ncbi.nlm.nih.gov/30728174

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The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Autor: Michael D. Milsom, Ronald Mathieu, Rachelle Kosoff, Pavankumar N. G. Reddy, Adrienne M. Dorrance, Chad E. Harris, Serena De Vita, Steven W. Lane, Jonathan Chernoff, Meaghan McGuinness, David A. Williams, Maria Radu

Publikováno v: Blood. 121:2474-2482

The p21-activated kinases (Paks) are serine/threonine kinases that are major effectors of the Rho guanosine 5'\x{2011}triphosphatase, Rac, and Cdc42. Rac and Cdc42 are known regulators of hematopoietic stem and progenitor cell (HSPC) function, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d484b41a1940de20b9161359b5d5d1b
https://doi.org/10.1182/blood-2012-10-460709

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Perivascular deletion of murine Rac reverses the ratio of marrow arterioles and sinusoid vessels and alters hematopoiesis in vivo

Autor: Shin-Young Park, Leslie E. Silberstein, David A. Williams, Ronald Mathieu, Kimberly J. Canty, Marioara F. Ciuculescu

Publikováno v: Blood. 125(20)

Hematopoietic stem cells (HSCs) are localized within specialized microenvironments throughout the BM. Nestin-expressing (Nestin(+)) mesenchymal stromal cells (MSCs) are important in the perivascular space. Rac is critical for MSC cell shape in vitro,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8b62e8cfd5755069b11e51e3dc1475
https://pubmed.ncbi.nlm.nih.gov/25824687

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A119: Deep Sequencing Analysis of the T Regulatory and T Effector Repertoire in Juvenile Idiopathic Arthritis

Autor: Stefano Volpi, Fatma Dedeoglu, Robert P. Sundel, Ronald Mathieu, Luigi D. Notarangelo, Francesco Frugoni, Peter A. Nigrovic, Lauren A. Henderson, Mindy S. Lo, Yu Nee Lee, Susan Kim, Erin Janssen, Robert C. Fuhlbrigge, Melissa M. Hazen

Publikováno v: Arthritis & Rheumatology. 66:S156-S156

Background/Purpose: T regulatory (Treg) function has been shown to be impaired in juvenile idiopathic arthritis (JIA) as synovial fluid (SF) Tregs are unable to suppress T effector cells (Teffs) found in the joint. The cause of this breach in immunol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7756e1a2ee926ec57e9b594e5718bdb0
https://doi.org/10.1002/art.38540

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