Výsledky vyhledávání - "Ronald M. Shymko"

Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding

Autor: Eric Dumont, Ronald M. Shymko, P De Meyts, Jacques Emile Dumont

Publikováno v: Biochemical Journal. 339:675-683

Mitogenic signalling through the insulin receptor is enhanced compared with metabolic signalling for insulin analogues having slower dissociation kinetics than insulin itself. A plausible explanation in molecular terms of this timing-dependent specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bf15d3143caab4ecb7e43512e5b945e
https://doi.org/10.1042/bj3390675

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Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture

Autor: Hans Hauner, W Teller, Martin Wabitsch, Pierre De Meyts, E Heinze, Ronald M. Shymko, Mapoko M. Ilondo

Publikováno v: Metabolism. 45:34-42

The effects of human growth hormone (hGH) on proliferation and differentiation of primary adipocyte precursor cells isolated from rat epididymal fat pads were studied under serum-free culture conditions. hGH markedly reduced the formation of new fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b81cd31a11c2c054975cecdf1741ae
https://doi.org/10.1016/s0026-0495(96)90197-3

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Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases

Autor: Brenda Wallach, Karen Grønskov, Birgitte Ursø, Ronald M. Shymko, Claus T. Christoffersen, Fumiatsu Yakushiji, Pierre De Meyts

Publikováno v: Metabolism. 44:2-11

The signal transduction pathways activated by hormones, growth factors, and cytokines show an extraordinary degree of cross-talk and redundancy. This review addresses the question of how the specificity conferred at the binding step is maintained thr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05bda9c60ddbc8c22ddd07047df04eb
https://doi.org/10.1016/0026-0495(95)90214-7

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Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor

Autor: P De Meyts, J ten Hoeve, Henrik Vissing, Claus T. Christoffersen, Noe Gonzales, John Groffen, Karin E. Bornfeldt, Nora Heisterkamp, Ronald M. Shymko, C M Rotella

Publikováno v: Endocrinology. 135:472-475

Insulin and insulin-like growth factor-I (IGF-I) share a spectrum of metabolic and growth-promoting effects, mediated through homologous receptors that belong to the tyrosine kinase family. The dissociation rate of insulin from its receptor is affect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ad9816dfcf63bf3d9376a2fddd3cc4
https://doi.org/10.1210/endo.135.1.8013387

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Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes

Autor: Ronald M. Shymko, P De Meyts, James A. Wells, M M Ilondo, A B Damholt, B A Cunningham

Publikováno v: Endocrinology. 134:2397-2403

Binding of GH to its cell surface receptors is thought to result in the formation of a complex comprised of one molecule of hormone per two molecules of receptor. It has been proposed that this hormone-induced receptor dimerization is important for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027eb19f1661f3530421aa62cdd785c1
https://doi.org/10.1210/endo.134.6.8194466

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The Insulin-Like Growth Factor-I Receptor

Autor: Ronald M. Shymko, M. Mapoko Ilondo, Lori-Jo Latus, Fumiatsu Yakushiji, Birgitte Ursø, Brenda Wallach, Pierre De Meyts, Karen Grønskov, Claus T. Christoffersen

Publikováno v: Hormone Research. 42:152-169

The nonclassical binding kinetics of IGF-I and insulin to their respective receptors, suggestive of negative cooperativity, can be readily explained by our recently proposed novel binding mechanism wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fa4b7f239cbacb27365dc5eb0b8ded8
https://doi.org/10.1159/000184188

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Identification of a Ligand-Binding Region of the Human Insulin Receptor Encoded by the Second Exon of the Gene

Autor: Jia Li Gu, Jonathan Whittaker, Pierre De Meyts, Bruce E. Kaplan, Graeme I. Bell, Ronald M. Shymko

Publikováno v: Molecular Endocrinology. 4:409-416

Structure-function studies of the insulin molecule indicate that an insulin B chain domain comprising residues 22-26 is involved both in binding to the insulin receptor (INSR) and in insulin dimer formation, suggesting that this domain might also int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0412c6739b495adf14a35dc8a4d27092
https://doi.org/10.1210/mend-4-3-409

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