Výsledky vyhledávání - "Ronald M. Rerko"

15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors

Autor: Earl Lawrence, Dawn M. Dawson, Monica M. Bertagnolli, Ronald M. Rerko, Robert A. Newman, Danielle Liu, Xiaohua Zhou, James Lutterbaugh, Stephen P. Fink, Seung-Jae Myung, Sanford D. Markowitz, Peiying Yang, Min Yan, Hsin Hsiung Tai, Joseph Willis, Jill S. Barnholtz-Sloan

Publikováno v: Proceedings of the National Academy of Sciences. 106:9409-9413

Pharmacologic inhibitors of the prostaglandin-synthesizing COX-2 oncogene prevent the development of premalignant human colon adenomas. However, resistance to treatment is common. In this study, we show that the adenoma prevention activity of the COX

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c85932d0f1f563075e608d98feadd
https://doi.org/10.1073/pnas.0902367106

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15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers

Autor: Keith T. Wilson, Ronald M. Rerko, Min Tong, Guangbin Luo, James K V Willson, Shilong Lu, Sanford D. Markowitz, Dawn M. Dawson, Min Yan, Hsin Hsiung Tai, James Lutterbaugh, Joseph Willis, Jack O. Hensold, Earl Lawrence, Petra Platzer

Publikováno v: Proceedings of the National Academy of Sciences. 101:17468-17473

Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afba571db06db2d4149818c178e5fefe
https://doi.org/10.1073/pnas.0406142101

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SLC5A8 , a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers

Autor: Sanford D. Markowitz, Theresa P. Pretlow, Lois Myeroff, Dominic J. Smiraglia, Ronald M. Rerko, Graham Casey, James Lutterbaugh, Michael F. Romero, Christoph Plass, Hui Li, James K V Willson, Jean Pierre J. Issa, Joseph Willis, Lakshmi Kasturi

Publikováno v: Proceedings of the National Academy of Sciences. 100:8412-8417

We identify a gene, SLC5A8 , and show it is a candidate tumor suppressor gene whose silencing by aberrant methylation is a common and early event in human colon neoplasia. Aberrant DNA methylation has been implicated as a component of an epigenetic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d1c1cd5539c49369e73e94c47d8b5f
https://doi.org/10.1073/pnas.1430846100

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Increased Capacity for Interleukin-2 Synthesis Parallels Disease Progression in Mice Infected with Leishmania major

Autor: Ronald M. Rerko, Frederick P. Heinzel, Richard A. Maier, Andrea M. Hujer

Publikováno v: Infection and Immunity. 66:4537-4540

Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon defic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e060aec82c6729fe140881fa562f69e7
https://doi.org/10.1128/iai.66.9.4537-4540.1998

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Immunoregulation of murine leishmaniasis by interleukin-12

Autor: Andrea M. Hujer, Ronald M. Rerko, Frederick P. Heinzel, F. Ahmed

Publikováno v: Research in Immunology. 146:575-582

Summary Distinct phenotypic outcomes following infection of mice with Leishmania major are closely linked to the emergence of functionally dissimilar Th1 or Th2 CD4+ T-cell responses early in the course of disease. This model of T-cell-dependent micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522603d72c225462b5e15185693e6118
https://doi.org/10.1016/0923-2494(96)83034-3

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PHOTOFRIN II PHOTOSENSITIZATION IS MUTAGENIC AT THE tk LOCUS IN MOUSE L5178Y CELLS

Autor: Marian E. Clay, Helen H. Evans, Nancy L. Oleinick, Antonio R. Antunez, Ronald M. Rerko

Publikováno v: Photochemistry and Photobiology. 55:75-80

— Photosensitization mediated by Photofrin II (PFII) was found to be mutagenic at the heterozygous thymidine kinase (tk) locus in mouse L5178Y lymphoma strains LY-S1 and LY-R16 but not in strain LY-R83 which is hemizygous at the tk locus. After tre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8effab8f2cb164ae410b52bb91301c
https://doi.org/10.1111/j.1751-1097.1992.tb04211.x

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15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis

Autor: Theresa P. Pretlow, Petra Platzer, Min Yan, Earl Lawrence, Robert A. Newman, Alysia Kern Lovgren, Andrew J. Dannenberg, Sanford D. Markowitz, Joseph Willis, Guangbin Luo, Seung-Jae Myung, Dawn M. Dawson, Kishore Guda, Ronald M. Rerko, Angela Dotson

15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers. Herein, we demonstrate that 15-PGDH is active in vivo as a highly pot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f61ded683d6b13bfdc2706232d9965
https://europepmc.org/articles/PMC1567703/

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PMEPA1, a transforming growth factor-beta-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer

Autor: Elaine B, Brunschwig, Keith, Wilson, David, Mack, Dawn, Dawson, Earl, Lawrence, James K V, Willson, ShiLong, Lu, Arman, Nosrati, Ronald M, Rerko, Sandra, Swinler, Lydia, Beard, James D, Lutterbaugh, Joseph, Willis, Petra, Platzer, Sanford, Markowitz

Publikováno v: Cancer research. 63(7)

To identify potential effectors of transforming growth factor (TGF)-beta-mediated suppression of colon cancer, we used GeneChip expression microarrays to identify TGF-beta-induced genes in VACO 330, a nontransformed TGF-beta-sensitive cell line deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::77b99f86668d6515c09eeba5d104214a
https://pubmed.ncbi.nlm.nih.gov/12670906

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Cure of progressive murine leishmaniasis: interleukin 4 dominance is abolished by transient CD4(+) T cell depletion and T helper cell type 1-selective cytokine therapy

Autor: Frederick P. Heinzel, Ronald M. Rerko

Publikováno v: The Journal of Experimental Medicine

Progressive infection with Leishmania major in susceptible BALB/c mice is mediated by interleukin (IL)-4–producing T helper cell type 2 (Th2) CD4+ T cells that, once established, become resistant to Th1-deviating therapies with recombinant (r)IL-12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d098e2533f0c7cf274d61627e8a5ee53
https://pubmed.ncbi.nlm.nih.gov/10377185

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Underproduction of interleukin-12 in susceptible mice during progressive leishmaniasis is due to decreased CD40 activity

Autor: Ronald M. Rerko, Frederick P. Heinzel, Andrea M. Hujer

Publikováno v: Cellular immunology. 184(2)

Interleukin-12 promotes Th1 lymphocyte responses necessary for the cure of murine Leishmania major infection. We found that IL-12 p40 mRNA expression peaked at 4 weeks of infection in resistant C57BL/6 mice at levels threefold greater than in BALB/c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1591e17c4607f85b22507b88673cca
https://pubmed.ncbi.nlm.nih.gov/9630839

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