Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ronald M. Norton"'
Publikováno v:
Drug Development Research. 25:229-234
We employed broken cell liver preparations in order to investigate potential species-specific differences in the metabolism of BW 1370U87, a new selective and reversible MAO-A inhibitor. The drug metabolizing capacity of crude liver homogenates from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff70d4c2abb3447b8e3998e788dd620
https://doi.org/10.1002/ddr.430250308
https://doi.org/10.1002/ddr.430250308
Autor:
Greg C. Rigdon, Otto Beek, Robert M. Ferris, G. W. Kraemer, Ronald M. Norton, Helen L. White, Barrett R. Cooper, James L. Howard
Publikováno v:
Drug Development Research. 25:181-190
BW 1370U87 is a potent, reversible, selective inhibitor of rat and human brain MAO-A with a competitive mechanism of action. The ED50 of BW 1370U87 for inhibition of MAO-A in rat brain is 8 mg/kg after oral administration, and the duration of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01e7335b5b77365b680dada0fe88a54e
https://doi.org/10.1002/ddr.430250302
https://doi.org/10.1002/ddr.430250302
Autor:
Ronald M Norton
Publikováno v:
Drug discovery today. 6(4)
Within the pharmaceutical industry, the application of clinical pharmacogenomics promises to enhance the discovery of drug response markers, reduce the size and expense of clinical drug trials and provide a new tool for addressing regulatory approval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d2d152418c9340c4f5f2883c307327
https://pubmed.ncbi.nlm.nih.gov/11173265
https://pubmed.ncbi.nlm.nih.gov/11173265
Autor:
Peter J. Gengo, Michael J. Durcan, Ching M. Wang, Anne V. Russell, Philip F. Morgan, Ronald M. Norton, Barrett R. Cooper, Stacy A. Jones-Humble, Richard F. Cox, Donald Lyerly, Flora L.M. Tang, Michael J. Watson
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 15(3)
11192U90 was submitted to receptor binding and monoamine uptake assays. It bound potently at serotonin 5-HT2, dopaminergic D2, serotonin 5-HT1A, and adrenergic alpha 1 and alpha 2 receptors. It also bound to dopaminergic D1, serotonin 5-HT3, serotoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6d87f697c4f774b5f233f30d8a0380
https://pubmed.ncbi.nlm.nih.gov/8873105
https://pubmed.ncbi.nlm.nih.gov/8873105
Publikováno v:
Stroke. 26(3)
Background and Purpose Elevated glutamate levels are thought to be a primary cause of neuronal death after global cerebral ischemia. The purpose of this study was to investigate the potential neuroprotective effects of lamotrigine, a novel antiepilep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7c0e152ac4d122051818ea8d662cf1
https://pubmed.ncbi.nlm.nih.gov/7886726
https://pubmed.ncbi.nlm.nih.gov/7886726
Autor:
Ronald M. Norton, Virginia Shea, Robert M. Ferris, Barrett R. Cooper, Ching M. Wang, Richard F. Cox
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 11(2)
Bupropion (BW 323U66) has been considered a dopaminergic antidepressant based on its ability to inhibit the uptake of dopamine (DA) somewhat more selectively than it inhibits uptake of norepinephrine (NE) or serotonin (5-HT). This report describes ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63cd22bf6a49255334392bf2d4456ab8
https://pubmed.ncbi.nlm.nih.gov/7840865
https://pubmed.ncbi.nlm.nih.gov/7840865
Publikováno v:
Journal of chromatography. 572(1-2)
A sensitive high-performance liquid chromatographic method that does not require organic extraction has been developed for the determination of propranolol levels in canine and feline plasma. Equal volumes of plasma and a mixture of methanol-acetonit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f9c48f9c9077d4591f3aff831c49bf
https://pubmed.ncbi.nlm.nih.gov/1818057
https://pubmed.ncbi.nlm.nih.gov/1818057
Autor:
Ronald M Norton
Publikováno v:
Drug Discovery Today. 7:1085
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a87153ecf2301ddbe5a6009fad139b79
https://doi.org/10.1016/s1359-6446(02)02401-7
https://doi.org/10.1016/s1359-6446(02)02401-7
Publikováno v:
Toxicology and Applied Pharmacology. 59:287-292
If glycolysis is inhibited in distal axonopathy, there should be a concomitant inhibition of lipogenesis from glucose. To investigate this possibility, lipogenesis from [14C]glucose and [3H]acetate was studied in sciatic nerves incubated with iodoace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b24d582951e1dfff0dd85877a65f314
https://doi.org/10.1016/0041-008x(81)90200-3
https://doi.org/10.1016/0041-008x(81)90200-3
Publikováno v:
Toxicology and Applied Pharmacology. 62:262-272
The chronic administration of 2,5-hexanedione (2,5-HD) to experimental animals can cause azoospermia and morphologic changes in central nervous system (CNS) areas related to visual and motor function. The present experiments were designed to determin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a8447c5b1ee0df901287db85fdbc97a
https://doi.org/10.1016/0041-008x(82)90124-7
https://doi.org/10.1016/0041-008x(82)90124-7