Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ronald M. Humphrey"'
Publikováno v:
Mutation Research/Genetic Toxicology. 261:267-279
The initiation of carcinogenesis by carcinogens such as 7 r ,8 t -dihydroxy-9,10 t -oxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene (BPDE-I) is thought to involve the formation of DNA adducts. However, the diastereomeric diol epoxide, 7 r ,8 t -dihydroxy-9,1
Publikováno v:
Mutation research. 261(4)
Insights into the mechanisms of chemical carcinogenesis can sometimes be gained by comparing the effects of closely related chemicals which differ in carcinogenic potency. We have treated Chinese hamster ovary (CHO) cells with a non-carcinogenic meta
Publikováno v:
Plasmid. 25(3)
A plasmid was constructed by fusion of a selectable mammalian gene, hamster adenine phosphoribosyltransferase ( APRT ), to the Zn 2+ -inducible sheep metallothionein I (MT I) promoter. This plasmid was used to produce stable Chinese hamster ovary (CH
Publikováno v:
Molecular carcinogenesis. 4(6)
We previously showed that ultraviolet (UV) irradiation of cotransfected plasmid DNA molecules stimulated genetic transformation that depended on intermolecular homologous recombination in Chinese hamster ovary (CHO) cells. Repair-proficient cells and
Publikováno v:
Photochemistry and Photobiology. 20:221-226
—As an aid to understanding the relationship between dimer repair and cellular recovery, we have studied dimer removal and replication of dimer-containing DNA in Chinese hamster ovary (CHO) cells irradiated with ultraviolet light (254 nm). These in
Autor:
Eugene W. Gerner, Ronald M. Humphrey
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis. 331:117-127
The synthesis of non-histone chromosomal proteins was studied as a function of cell-cycle position in synchronized Chinese hamster cells. Although non-histones were synthesized in all phases of the cell cycle studied, non-histone synthesis was 3–5
Publikováno v:
Proceedings of the National Academy of Sciences. 75:1919-1923
Electrophoretic shift mutants induced in Chinese hamster ovary (CHO) cells indicate that these cells not extensively functionally hemizygotic. Therefore, effective haploidy is unsatisfactory as a general theory to explain the frequency of recessive m
Publikováno v:
Cancer. 34:526-531
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 199:243-254
The formation of DNA adducts by the ultimate carcinogen 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene (BPDE-I) has been implicated in the process of carcinogenesis. In a line of Chinese hamster ovary (CHO) cells designated AT3-2 an
Publikováno v:
Journal of Biochemical and Biophysical Methods. 6:95-103
Two methods of quantitative, fluorescent detection of DNA bands in agarose gels separated by electrophoresis were evaluated for sensitivity and linearity of response. Comparisons of ethidium bromide staining with a method using 4′,6-diamidino-2-phe