Výsledky vyhledávání - "Ronald M, Burch"

Akademický článek

Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

The rapid protease degradation of peptides is currently limiting their therapeutic utility. Here, the authors report functionalised thiocarbazate scaffolds as precursors of aza-amino acids that can be integrated in peptide sequences, extending their

Externí odkaz: https://doaj.org/article/a48c24524daa4e5cb8838c0018607cb6

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The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

Autor: Joseph R. Moskal, M. Amin Khan, John F. Disterhoft, Patric K. Stanton, Ronald M. Burch, Roger A. Kroes, Jeffrey Burgdorf

Publikováno v: Current Neuropharmacology

Background: Rapastinel (GLYX-13) is a NMDA receptor modulator with glycine-site partial agonist properties. It is a robust cognitive enhancer and shows rapid and long-lasting antidepressant properties in both animal models and in humans. Methods: Rap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1899579844538d76fe3ee477750b47e0
http://europepmc.org/articles/PMC5327451

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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

Autor: Joseph R. Moskal, Roger A. Kroes, Ronald M. Burch, J. David Leander, John F. Disterhoft, Jeffrey Burgdorf, Patric K. Stanton

Publikováno v: Expert Opinion on Investigational Drugs. 23:243-254

The N-methyl-d-aspartate receptor-ionophore complex plays a key role in learning and memory and has efficacy in animals and humans with affective disorders. GLYX-13 is an N-methyl-d-aspartate receptor (NMDAR) glycine-site functional partial agonist a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f005bfe134f20186d669ad38b4c41413
https://doi.org/10.1517/13543784.2014.852536

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Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats

Autor: Jeffrey Burgdorf, Roger A. Kroes, Joseph R. Moskal, Amanda L. Gross, Ronald M. Burch, Craig Weiss, John F. Disterhoft, Mary F. Schmidt, Xiao-Lei Zhang, Patric K. Stanton

Publikováno v: Behavioural brain research. 294

Rapastinel (GLYX-13) is a NMDA receptor modulator with glycine-site partial agonist properties. It is a robust cognitive enhancer and shows rapid and long-lasting antidepressant properties in both animal models and in humans. Contextual fear extincti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c354490f7e53d67adee87f6866446ac
https://pubmed.ncbi.nlm.nih.gov/26210936

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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

Autor: Ronald M. Burch, S.R. Boikess, Craig Weiss, Xiao-Lei Zhang, Patric K. Stanton, Joseph R. Moskal, Roger A. Kroes, Amanda L. Gross, Jeffrey Burgdorf, John F. Disterhoft, Christopher S. Rex, M. A. Khan

Publikováno v: Neuroscience. 308

Rapastinel (GLYX-13) is an N-methyl-d-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Rapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4445469f44fa24235ee8e87276e3784b
https://pubmed.ncbi.nlm.nih.gov/26343295

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Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

Autor: Sheldon, Preskorn, Matthew, Macaluso, D O Vishaal, Mehra, Gary, Zammit, Joseph R, Moskal, Ronald M, Burch, Rick, Mofsen

Publikováno v: Journal of psychiatric practice. 21(2)

Approximately 45% of patients with major depressive disorder (MDD) do not remit when treated with biogenic amine antidepressants. Consequently, there is a significant need for antidepressant agents with different mechanisms of action. Early proof of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126b36593df8f87b8d4f37d3973e541c
https://pubmed.ncbi.nlm.nih.gov/25782764

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Inhibition of neutrophil adhesion during cardiopulmonary bypass

Autor: Jenny M. Bator, William E. Curtis, Duke E. Cameron, J.Mark Redmond, Kenton J. Zehr, William A. Baumgartner, A. Marc Gillinov, Bruce A. Reitz, Ahvie Herskowitz, Ian C. Wilson, Ronald M. Burch

Publikováno v: The Annals of Thoracic Surgery. 57:126-133

Blood contact with synthetic surfaces during cardiopulmonary bypass (CPB) causes a diffuse inflammatory reaction that includes neutrophil activation. The purpose of this study was to determine if inhibition of neutrophil adhesion with a new antiinfla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd43e9dd71fd2248b42facf5c30c175
https://doi.org/10.1016/0003-4975(94)90380-8

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Inhibition of neutrophil adhesion reduces myocardial infarct size

Autor: A. Marc Gillinov, Jenny M. Bator, Timothy J. Gardner, William E. Curtis, Duke E. Cameron, Ian C. Wilson, Ronald M. Burch

Publikováno v: The Annals of Thoracic Surgery. 56:1069-1073

Neutrophil accumulation and activation within the myocardium during ischemia and reperfusion has been shown to play a prominent role in the development of myocardial stunning and infarction. To determine if a simple inhibitor of neutrophil adhesion c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c589282b4f540e94208966f27c5856
https://doi.org/10.1016/0003-4975(95)90015-2

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