Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Ronald Leuchter"'
Autor:
Sally Mortlock, Rosario I. Corona, Pik Fang Kho, Paul Pharoah, Ji-Heui Seo, Matthew L. Freedman, Simon A. Gayther, Matthew T. Siedhoff, Peter A.W. Rogers, Ronald Leuchter, Christine S. Walsh, Ilana Cass, Beth Y. Karlan, B.J. Rimel, Grant W. Montgomery, Kate Lawrenson, Siddhartha P. Kar
Publikováno v:
2022, ' A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes ', Cell Reports Medicine, vol. 3, no. 3, 100542 . https://doi.org/10.1016/j.xcrm.2022.100542
Endometriosis is associated with increased risk of epithelial ovarian cancers (EOCs). Using data from large endometriosis and EOC genome-wide association meta-analyses, we estimate the genetic correlation and evaluate the causal relationship between
Autor:
Kelly L, Bolton, Georgia, Chenevix-Trench, Cindy, Goh, Siegal, Sadetzki, Susan J, Ramus, Beth Y, Karlan, Diether, Lambrechts, Evelyn, Despierre, Daniel, Barrowdale, Lesley, McGuffog, Sue, Healey, Douglas F, Easton, Olga, Sinilnikova, Javier, Benítez, María J, García, Susan, Neuhausen, Mitchell H, Gail, Patricia, Hartge, Susan, Peock, Debra, Frost, D Gareth, Evans, Rosalind, Eeles, Andrew K, Godwin, Mary B, Daly, Ava, Kwong, Edmond S K, Ma, Conxi, Lázaro, Ignacio, Blanco, Marco, Montagna, Emma, D'Andrea, Maria Ornella, Nicoletto, Sharon E, Johnatty, Susanne Krüger, Kjær, Allan, Jensen, Estrid, Høgdall, Ellen L, Goode, Brooke L, Fridley, Jennifer T, Loud, Mark H, Greene, Phuong L, Mai, Angela, Chetrit, Flora, Lubin, Galit, Hirsh-Yechezkel, Gord, Glendon, Irene L, Andrulis, Amanda E, Toland, Leigha, Senter, Martin E, Gore, Charlie, Gourley, Caroline O, Michie, Honglin, Song, Jonathan, Tyrer, Alice S, Whittemore, Valerie, McGuire, Weiva, Sieh, Ulf, Kristoffersson, Håkan, Olsson, Åke, Borg, Douglas A, Levine, Linda, Steele, Mary S, Beattie, Salina, Chan, Robert L, Nussbaum, Kirsten B, Moysich, Jenny, Gross, Ilana, Cass, Christine, Walsh, Andrew J, Li, Ronald, Leuchter, Ora, Gordon, Montserrat, Garcia-Closas, Simon A, Gayther, Stephen J, Chanock, Antonis C, Antoniou, Paul D P, Pharoah, Roger, Milne
Publikováno v:
JAMA. 307(4)
Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2-related EOC was associated with an improved prognosis, but the effect of BRCA1 rema