Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ronald L. Morgan"'
Large-scale purification of haptenated oligonucleotides using high-performance liquid chromatography
Autor:
Joseph E. Celebuski, Ronald L. Morgan
Publikováno v:
Journal of Chromatography A. 536:85-93
We report methodology for the succesful separation of unreacted oligonucleotide from end labeled material (fluorescein or biotin) on an milligram scale using high-performance liquid chromatography (HPLC). The oligonucleotides (19–24-mers) were synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e84aae234da47168537c4b10d35bd14
https://doi.org/10.1016/s0021-9673(01)89238-4
https://doi.org/10.1016/s0021-9673(01)89238-4
Autor:
E. P. Cannon, Charmille B. Tamulinas, Jon Leong‐Way, James L. Way, Carie Chui, Lynn Baxter, Amina Nagi, Ronald L. Morgan, Peter Leung
Publikováno v:
Novartis Foundation Symposia ISBN: 9780470513712
Ciba Foundation Symposium 140 - Cyanide Compounds in Biology
Ciba Foundation Symposium 140 - Cyanide Compounds in Biology
The mechanism of cyanide intoxication has been attributed to the inhibition of cytochrome oxidase, thereby decreasing the tissue utilization of oxygen. One mechanism of cyanide antagonism is by sequestering cyanide with methaemoglobin to form cyanmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7adb7820681ad06a17adcd361d11c4e0
https://doi.org/10.1002/9780470513712.ch14
https://doi.org/10.1002/9780470513712.ch14
Upon base composition analysis, oligonucleotides which are labeled at the 3'-terminus with fluorescein or biotin generate an additional, late eluting peak in the HPLC chromatogram. Investigation of this effect revealed the haptens acted as apurinic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9a93f9c6557d833a0b82b9fc2301b9
https://europepmc.org/articles/PMC311192/
https://europepmc.org/articles/PMC311192/
Publikováno v:
Avian Diseases. 38:733
Eight-week-old chickens were inoculated with one of two exotic viruses to determine the effect of composting on virus survival. Group 1 chickens were inoculated with highly pathogenic avian influenza (HPAI) virus via the caudal thoracic air sac. Grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2f23b913850591be767c0e3f96f1ee
https://doi.org/10.2307/1592108
https://doi.org/10.2307/1592108
Autor:
J. L. Way, Gary E. Isom, George E. Burrows, James L. Way, Charmille B. Tamulinas, D. Sylvester, Ronald L. Morgan
Publikováno v:
Fundamental and Applied Toxicology. 4:S231-S239
The mechanism of action of nitrite-thiosulfate (Chen et al., 1933a ,b; Hug , 1933) in the antagonism of the lethal effects of cyanide is much more complex than proposed 50 years ago. Some of the recent findings concerning the mechanism of nitrite act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8c2a2738ea80d91cd76cfe54b07089a
https://doi.org/10.1016/0272-0590(84)90157-x
https://doi.org/10.1016/0272-0590(84)90157-x
Publikováno v:
Toxicology and Applied Pharmacology. 69:265-271
One method to treat cyanide poisoning involves the administration of a combination of sodium thiosulfate and sodium nitrite. Sodium thiosulfate is believed to exert its antidotal effect by serving as a sulfur donor, thereby increasing the rate of rho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e23b664c0472d95a6faa3dc2ef23ad
https://doi.org/10.1016/0041-008x(83)90307-1
https://doi.org/10.1016/0041-008x(83)90307-1
Publikováno v:
Toxicology and Applied Pharmacology. 55:103-107
A sensitive, specific fluorometric method has been combined with microdiffusion to measure cyanide in biological fluids. Cyanide reacts with p-benzoquinone to form fluorescent product(s) which are determined in dimethyl sulfoxide. Approximately 0.001
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4bfd38aa1205c9cbef5782eb93129e
https://doi.org/10.1016/0041-008x(80)90225-2
https://doi.org/10.1016/0041-008x(80)90225-2
Autor:
Ronald L. Morgan, James L. Way
Publikováno v:
Journal of Analytical Toxicology. 4:78-81
Investigations of the physiological disposition of cyanide during thiosulfate therapy has necessitated the development of a convenient and sensitive method for cyanide analysis. A fluorometric method involving the catalytic conversion of pyridoxal to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2530d9ebe3809773d6d47b96f04cfe7a
https://doi.org/10.1093/jat/4.2.78
https://doi.org/10.1093/jat/4.2.78
Publikováno v:
Journal of the American Society for Mass Spectrometry. (7):660-667
A simple and powerful method for the determination of labeling sites on oligodeoxynucleotides (ODN) has been developed. The method is based on the finding that nuclease P1 (NP1) digestions of label-containing ODNs produce site-specific products: 5′
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee3b0b0791d901413392eef848d7e4e5
Publikováno v:
Toxicologic pathology. 13(3)
Two insecticide formulations were evaluated for skin irritation using albino rabbits (Stauffland-White strain). While the active ingredient alone produced only mild skin irritation, corn grit formulation produced severe skin irritation. Corn grit fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cca5d8788a5eb18dbcab7ecd68877e
https://pubmed.ncbi.nlm.nih.gov/4070929
https://pubmed.ncbi.nlm.nih.gov/4070929