Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ronald L. Meyer"'
Publikováno v:
Brain Research. 1613:13-26
A great deal of effort has been invested in using trophic factors and other bioactive molecules to promote cell survival and axonal regeneration in the adult central nervous system. Far less attention has been paid to investigating potential effects
Autor:
Jill Miotke, Joel M. Levine, Ronald L. Meyer, Ken-Ichi Takemaru, Michael Coulter, Justin P. Rodriguez
Publikováno v:
Journal of Neuroscience. 34:10285-10297
When the brain or spinal cord is injured, glial cells in the damaged area undergo complex morphological and physiological changes resulting in the formation of the glial scar. This scar contains reactive astrocytes, activated microglia, macrophages a
Autor:
Ronald L. Meyer, Brad J. Kolls
Publikováno v:
Journal of Neuroscience Research. 91:1263-1279
During development, neuronal activity is used as a cue to guide synaptic rearrangements to refine connections. Many studies, especially in the visual system, have shown that the N-methyl-D-aspartate receptor (NMDAr) plays a key role in mediating acti
Autor:
Timo A. Nieminen, Halina Rubinsztein-Dunlop, Jill Miotke, Michael W. Berns, Tao Wu, Ronald L. Meyer, Samarendra K. Mohanty
Publikováno v:
Nature Photonics. 6:62-67
Axonal path-finding is important in the development of the nervous system, nerve repair and nerve regeneration. The behaviour of the growth cone at the tip of the growing axon determines the direction of axonal growth and migration. We have developed
Publikováno v:
The Journal of Comparative Neurology. 500:384-400
Ciliary neurotrophic factor (CNTF) is important for the survival and outgrowth of retinal ganglion cells (RGCs) in vitro. However, in vivo adult RGCs fail to regenerate and subsequently die following axotomy, even though there are high levels of CNTF
Autor:
Bradley J. Kolls, Ronald L. Meyer
Publikováno v:
The Journal of Neuroscience. 22:2626-2636
During development, waves of activity periodically spread across retina to produce correlated activity that is thought to drive activity-dependent ordering in optic fibers. We asked whether similar waves of activity are produced in the retina of adul
Autor:
James W. Fawcett, Ronald L. Meyer, Barbara J. Gour, Ilknur Ozen, Orest W. Blaschuk, Oliver Schnädelbach
Publikováno v:
Molecular and Cellular Neuroscience. 17:1084-1093
We have analyzed the influence of the calcium-dependent cell adhesion molecule, N-cadherin, on events leading to CNS myelination. Interactions between axons and oligodendrocyte progenitor (OP) cells and the CG4 OP cell line were examined by video-mic
Regenerating optic fibers correct large-scale errors by random growth: Evidence from in vivo imaging
Autor:
Ronald L. Meyer, Amy J. Dawson
Publikováno v:
The Journal of Comparative Neurology. 434:40-55
Regenerating optic fibers in goldfish make large-scale errors when they invade tectum and subsequently correct these to generate a projection with moderate retinotopic order by 1 month. The behavior of fibers underlying these extensive rearrangements
Autor:
Joanne Taylor, Melitta Schachner, Catherina G. Becker, Udo Bartsch, Brigitte Anliker, Thomas Becker, Ronald L. Meyer
Publikováno v:
Glia. 29:330-346
Tenascin-R, an extracellular matrix constituent expressed by oligodendrocytes and some neuronal cell types, may contribute to the inhibition of axonal regeneration in the adult central nervous system. Here we show that outgrowth of embryonic and adul
Autor:
Bradley J. Kolls, Ronald L. Meyer
Publikováno v:
The Journal of Neuroscience. 20:338-350
Spontaneous (not retinally driven) postsynaptic activity was examined during activity-dependent refinement of optic fibers in the goldfish tectum. Unit recordingsin vivoandin vitrodemonstrated that spontaneous tectal activity increased to 150% of nor