Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ronald L. Kochman"'
Autor:
Carl R. Mackerer, Ronald L. Kochman
Publikováno v:
Experimental Biology and Medicine. 158:393-397
SummaryThe effects of anions and cations on the specific binding of 3H-diazepam to rat brain were determined. Crude synaptic membranes from whole rat brain were prepared by differential centrifugation followed by hypo-osmotic shock and freezing. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891948e145e09160a672ae9c33624286
https://doi.org/10.3181/00379727-158-40211
https://doi.org/10.3181/00379727-158-40211
Occupation of brain receptors by benzodiazepines and ?-carbolines: Multiple mechanisms and responses
Autor:
Ronald L. Kochman, James D. Hirsch
Publikováno v:
Drug Development Research. 4:39-50
High affinity for the brain benzodiazepine receptor can no longer be considered predictive of benzodiazepine-like pharmacology in vivo. Studies of 3H-diazepam (3H-DZ) and 3H-propyl-β-carboline-3-carboxylate (3H-PrCC) binding were performed to invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1895beb41ff31cd2c39e58b5403d80d9
https://doi.org/10.1002/ddr.430040106
https://doi.org/10.1002/ddr.430040106
Publikováno v:
Peptides. 5:499-502
Intraperitoneal injection of sulfated cholecystokinin octapeptide (CCK-8; 10 micrograms/kg) resulted in an increase in the IC50 for isoproterenol (4.2 microM to 23.3 microM) in displacing 1 nM 3H-dihydroalprenolol binding to rat hypothalamic membrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14af2ff5078c864109c79f2483328924
https://doi.org/10.1016/0196-9781(84)90077-9
https://doi.org/10.1016/0196-9781(84)90077-9
Autor:
Cyndi K. Sepulveda, Ronald L. Kochman
Publikováno v:
Neurobiology of aging. 7(5)
The effects of GABA on benzodiazepine receptor binding in cerebral cortical, hippocampal, and cerebellar membranes from 2–3 months old and 28–32 months old rats were studied. GABA modulation of agonist, antagonist, and inverse agonist binding to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5de6498631476aa7edeb2491873b47b
https://pubmed.ncbi.nlm.nih.gov/3024043
https://pubmed.ncbi.nlm.nih.gov/3024043
Publikováno v:
Journal of medicinal chemistry. 20(11)
A series of beta-spiro[pyrrolidinoindolines], 3a-d, was prepared and evaluated for their ability to bind to the glycine receptor. These compounds were also tested in vivo to determine if they would produce convulsant or anxiolytic effects. The target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3850b54babc7f609dd89dcbdc72dc914
https://pubmed.ncbi.nlm.nih.gov/199727
https://pubmed.ncbi.nlm.nih.gov/199727