Výsledky vyhledávání - "Ronald L. Alkana"

Glycine and GABAAUltra-Sensitive Ethanol Receptors as Novel Tools for Alcohol and Brain Research

Autor: Karan H. Muchhala, Daya I. Perkins, Anna Naito, Gregg E. Homanics, James R. Trudell, Daryl L. Davies, Liana Asatryan, Ronald L. Alkana

Publikováno v: Molecular Pharmacology. 86:635-646

A critical obstacle to developing effective medications to prevent and/or treat alcohol use disorders is the lack of specific knowledge regarding the plethora of molecular targets and mechanisms underlying alcohol (ethanol) action in the brain. To id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64708cde449337a76f974a87293f9d32
https://doi.org/10.1124/mol.114.093773

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Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans

Autor: Daryl L. Davies, Nhat Huynh, Liana Asatryan, Michael Neely, Megan M. Yardley, Ronald L. Alkana, Stan G. Louie

Publikováno v: NeuroReport. 25:1018-1023

Ivermectin (IVM), an FDA approved anthelmintic agent, can significantly reduce ethanol intake in mice following acute administration. The current study evaluates the sustainability and safety of multiday IVM administration in reducing 10% v/v ethyl a

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https://doi.org/10.1097/wnr.0000000000000211

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Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders

Autor: James R. Trudell, Ronald L. Alkana, Sheraz Khoja, Megan M. Yardley, Nhat Hyunh, Nicos A. Petasis, Stan G. Louie, Liana Asatryan, Daryl L. Davies

Publikováno v: The International Journal of Neuropsychopharmacology. 17:907-916

Our laboratory is investigating ivermectin (IVM) and other members of the avermectin family as new pharmaco-therapeutics to prevent and/or treat alcohol use disorders (AUDs). Prior work found that IVM significantly reduced ethanol intake in mice and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57276ae1677ab5dffacfd97cb1d9940c
https://doi.org/10.1017/s1461145713001703

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Sociocommunicative and Sensorimotor Impairments in Male P2X4-Deficient Mice

Autor: Michael W. Jakowec, Sean C. Godar, Marco Bortolato, Daryl L. Davies, Letisha R. Wyatt, Ronald L. Alkana, Sheraz Khoja

Publikováno v: Neuropsychopharmacology. 38:1993-2002

Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosine 5'-triphosphate (ATP). Of the seven P2X subtypes, P2X4 receptors (P2X4Rs) are richly expressed in the brain, yet their role in behavioral organization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5715efa0c0cf943165df4fe66dcdee1a
https://doi.org/10.1038/npp.2013.98

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Ivermectin reduces alcohol intake and preference in mice

Autor: Ronald L. Alkana, Nhat Huynh, Sheraz Khoja, Megan M. Yardley, Nicos A. Petasis, Letisha R. Wyatt, Stan G. Louie, Deborah A. Finn, Marco Bortolato, Liana Asatryan, Daryl L. Davies, Marcia J. Ramaker

Publikováno v: Neuropharmacology. 63:190-201

The high rate of therapeutic failure in the management of alcohol use disorders (AUDs) underscores the urgent need for novel and effective strategies that can deter ethanol consumption. Recent findings from our group showed that ivermectin (IVM), a b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10253859de8a238ca56e6c6e3b1b4d3f
https://doi.org/10.1016/j.neuropharm.2012.03.014

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Charge and Geometry of Residues in the Loop 2 β Hairpin Differentially Affect Agonist and Ethanol Sensitivity in Glycine Receptors

Autor: Daya I. Perkins, Liana Asatryan, James R. Trudell, Ronald L. Alkana, Daryl L. Davies

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 341:543-551

Recent studies highlighted the importance of loop 2 of α1 glycine receptors (GlyRs) in the propagation of ligand-binding energy to the channel gate. Mutations that changed polarity at position 52 in the β hairpin of loop 2 significantly affected se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3849a2525d482159e2386f418a1a51bf
https://doi.org/10.1124/jpet.111.190942

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Ethanol Is a Fast Channel Inhibitor of P2X4 Receptors

Autor: Olga Ostrovskaya, Liana Asatryan, Kaixun Li, Ronald L. Alkana, Daryl L. Davies, Letisha R. Wyatt, Maya Popova, Robert W. Peoples

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 337:171-179

P2X receptors (P2XRs) are ion channels gated by synaptically released ATP. The P2X4 is the most abundant P2XR subtype expressed in the central nervous system and to date is the most ethanol-sensitive. In addition, genomic findings suggest that P2X4Rs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebba7825374488e393b3b2a4c1a344d
https://doi.org/10.1124/jpet.110.176990

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Molecular targets and mechanisms for ethanol action in glycine receptors

Autor: Ronald L. Alkana, James R. Trudell, Daryl L. Davies, Daya I. Perkins, Daniel K. Crawford

Publikováno v: Pharmacology & Therapeutics. 127:53-65

Glycine receptors (GlyRs) are recognized as the primary mediators of neuronal inhibition in the spinal cord, brain stem and higher brain regions known to be sensitive to ethanol. Building evidence supports the notion that ethanol acting on GlyRs caus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86715cdac5ea1f48e97780dd7c07ba11
https://doi.org/10.1016/j.pharmthera.2010.03.003

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A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors

Autor: Ronald L. Alkana, Olga Ostrovskaya, Maya Popova, Daryl L. Davies, Kaixun Li, Liana Asatryan, Letisha R. Wyatt

Publikováno v: Journal of Neurochemistry. 112:307-317

J. Neurochem. (2010) 112, 307–317. Abstract ATP-gated P2X4 receptors (P2X4R) are abundantly expressed in the CNS. However, little is known about the molecular targets for ethanol action in P2X4Rs. The current investigation tested the hypothesis tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d153b142b71ee57ddd6d2ff65d76631d
https://doi.org/10.1111/j.1471-4159.2009.06460.x

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Targets for ethanol action and antagonism in Loop 2 of the extracellular domain of glycine receptors

Autor: Daniel K. Crawford, Daya I. Perkins, James R. Trudell, Daryl L. Davies, Ronald L. Alkana

Publikováno v: Journal of Neurochemistry. 106:1337-1349

The present studies used increased atmospheric pressure in place of a traditional pharmacological antagonist to probe the molecular sites and mechanisms of ethanol action in glycine receptors (GlyRs). Based on previous studies, we tested the hypothes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a412306a7fb6d8ad900f1223bbae19c
https://doi.org/10.1111/j.1471-4159.2008.05476.x

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