Determinants of beat-to-beat variability of repolarization duration in the canine ventricular myocyte: a computational analysis.

Autor: Jordi Heijman, Antonio Zaza, Daniel M Johnson, Yoram Rudy, Ralf L M Peeters, Paul G A Volders, Ronald L Westra

Publikováno v: PLoS Computational Biology, Vol 9, Iss 8, p e1003202 (2013)

Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of cardiac function and a better marker of proarrhythmia than repolarization prolongation alone. The ionic mechanisms underlying baseline BVR in physiological co

Externí odkaz: https://doaj.org/article/5b17bf03146049a39498d6762beb9c64

Non-extensitivity and criticality of atomic hydropathicity around a voltage-gated sodium channel's pore

Autor: Hubert J.M. Smeets, Catharina G. Faber, Jordi Heijman, Patrick J. Lindsey, Yang Yang, Makros N Xenakis, Dimos Kapetis, Giuseppe Lauria, Ronald L. Westra, Stephen G. Waxman

Publikováno v: Journal of Biological Physics
Journal of Biological Physics, 47(1), 61-77. Springer

Voltage-gated sodium channels (NavChs) are pore-forming membrane proteins that regulate the transport of sodium ions through the cell membrane. Understanding the structure and function of NavChs is of major biophysical, as well as clinical, importanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c58ae2c4574b1e6ed7130bee60931be
https://doi.org/10.1007/s10867-021-09565-w

Cumulative hydropathic topology of a voltage-gated sodium channel at atomic resolution

Autor: Dimos Kapetis, Jordi Heijman, Patrick J. Lindsey, Yang Yang, Hubert J.M. Smeets, Giuseppe Lauria, M.N. Xenakis, Stephen G. Waxman, Ronald L. Westra, Catharina G. Faber

Publikováno v: Proteins-structure Function and Bioinformatics, 88(10), 1319-1328. Wiley-Liss Inc.

Voltage-gated sodium channels (NavChs) are biological pores that control the flow of sodium ions through the cell membrane. In humans, mutations in genes encoding NavChs can disrupt physiological cellular activity thus leading to a wide spectrum of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f92a07a592708ffa007901ff04973b
https://cris.maastrichtuniversity.nl/en/publications/0cfd6d7a-08da-4012-8c94-7975b216f128

Erratum: 'Effects of synaptic and myelin plasticity on learning in a network of Kuramoto phase oscillators' [Chaos 29, 083122 (2019)]

Autor: Thomas Burwick, Ronald L. Westra, Domenica Dibenedetto, P De Weerd, Mario Senden, Maryam Karimian, Michelle Moerel

Publikováno v: Chaos. 30(6)

This erratum corrects a mistake in the published paper. In the Acknowledgments: "M.S. was funded by the European Union s Horizon 2020 Research and Innovation Program under Grant Agreement No. 737691 (HBP SGA2). "The Grant Agreement No. 737691 is not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593148d940a9dd0699e645fb75593308
https://doi.org/10.1063/5.0013005

Physiology-based regularization of the electrocardiographic inverse problem

Autor: Nele Vandersickel, Michael Clerx, Matthijs J. M. Cluitmans, Ronald L. Westra, Paul G.A. Volders, Ralf Peeters

Publikováno v: Medical & Biological Engineering & Computing, 55(8), 1353-1365. Springer
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
Medical & Biological Engineering & Computing

The inverse problem of electrocardiography aims at noninvasively reconstructing electrical activity of the heart from recorded body-surface electrocardiograms. A crucial step is regularization, which deals with ill-posedness of the problem by imposin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75a02cd76d62e308bbb8b8f3fcadbd6c
https://doi.org/10.1007/s11517-016-1595-5