Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ronald Keith Webber"'
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681bd0252c2170629f7f44f4fd7f776a
https://doi.org/10.1021/jm9704715
https://doi.org/10.1021/jm9704715
Autor:
Suzanne Metz, Mahima Trivedi, William M. Moore, Timothy J. Hagen, Mark E. Zupec, Jane R. Connor, Mark G. Currie, B. S. Pitzele, Kam F. Fok, M. V. Toth, Pamela T. Manning, Ronald Keith Webber, D. W. Hansen, Gina M. Jerome, F. S. Tjoeng
Publikováno v:
Journal of Medicinal Chemistry. 41:96-101
A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl substitutions on the 4-position (3) or 4- and 6-positions (8) afforded the most potent analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0f40a0d108843036268d55d4ebec4b
https://doi.org/10.1021/jm9705059
https://doi.org/10.1021/jm9705059
Autor:
Ronald Keith Webber, William M. Moore, Pamela T. Manning, Sue Metz, Mihaly V. Toth, Alan E. Moormann, Gina M. Jerome, Donald W. Hansen, Christine Kornmeier, Barnett S. Pitzele
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:2651-2653
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9727b68b1b644f4201f4f9d03c3d37
https://doi.org/10.1016/s0960-894x(01)00523-6
https://doi.org/10.1016/s0960-894x(01)00523-6
Autor:
Alan E. Moormann, Donald W. Hansen, Gina M. Jerome, Sue Metz, Barnett S. Pitzele, Ronald Keith Webber, William M. Moore, Mihaly V. Toth, Pamela T. Manning, Christine Kornmeier
Publikováno v:
ChemInform. 33
The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring substitution of the 5-carbon for a heteroatom is presented. Potencies (IC50's) for these inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3946ff79ba2f2c48bff4fa5da1fe71
https://doi.org/10.1002/chin.200201177
https://doi.org/10.1002/chin.200201177
Autor:
Mark G. Currie, Thomas P. Misko, Gina M. Jerome, F. S. Tjoeng, Ronald Keith Webber, William M. Moore
Publikováno v:
Journal of medicinal chemistry. 37(23)
L-N6-(1-Iminoethyl)lysine (L-NIL) has been synthesized and is shown to be both a potent and selective inhibitor of mouse inducible nitric oxide synthase (miNOS). L-NIL has an IC50 of 3.3 microM for miNOS compared to an IC50 of 92 microM for rat brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d220d88b43fe00fd47bcfa217f4cd6d3
https://pubmed.ncbi.nlm.nih.gov/7525961
https://pubmed.ncbi.nlm.nih.gov/7525961