Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Ronald K. Freund"'
Autor:
Esteban M. Lucero, Ronald K. Freund, Alexandra Smith, Noah R. Johnson, Breanna Dooling, Emily Sullivan, Olga Prikhodko, Md. Mahiuddin Ahmed, David A. Bennett, Timothy J. Hohman, Mark L. Dell’Acqua, Heidi J. Chial, Huntington Potter
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105288- (2022)
Summary: Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. T
Externí odkaz:
https://doaj.org/article/b454f82fd1d14209a2333f435a60d98d
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109786- (2021)
Summary: Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) synaptic plasticity underlying learning and memory. In Alzheimer’s disease
Externí odkaz:
https://doaj.org/article/23a0b8662e1f4cf7a49b25844d4df719
Autor:
Steven J. Coultrap, Ronald K. Freund, Heather O’Leary, Jennifer L. Sanderson, Katherine W. Roche, Mark L. Dell’Acqua, K. Ulrich Bayer
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 431-437 (2014)
Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other kinases, whereas long-term depression (LTD) requires phosphatases. Here, we found that LTD also
Externí odkaz:
https://doaj.org/article/08b54df20b1e4e06a3ff111dabc8b360
Autor:
Olga Prikhodko, Jennifer L Sanderson, Ronald K Freund, Emily Sullivan, Matthew J Kennedy, Mark L Dell'Acqua
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b01ce4146c7e0dffe75a15a66d8eef14
https://doi.org/10.1002/alz.068826
https://doi.org/10.1002/alz.068826
Autor:
Jennifer L, Sanderson, Ronald K, Freund, Anna M, Castano, Timothy A, Benke, Mark L, Dell'Acqua
Publikováno v:
Neuropharmacology. 220
Genetic alterations in autism spectrum disorders (ASD) frequently disrupt balance between synaptic excitation and inhibition and alter plasticity in the hippocampal CA1 region. Individuals with Timothy Syndrome (TS), a genetic disorder caused by Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8dbcf5cc719ae4dca0a11ab905a4b67e
https://pubmed.ncbi.nlm.nih.gov/36162529
https://pubmed.ncbi.nlm.nih.gov/36162529
Autor:
Esteban M, Lucero, Ronald K, Freund, Alexandra, Smith, Noah R, Johnson, Breanna, Dooling, Emily, Sullivan, Olga, Prikhodko, Md Mahiuddin, Ahmed, David A, Bennett, Timothy J, Hohman, Mark L, Dell'Acqua, Heidi J, Chial, Huntington, Potter
Publikováno v:
iScience. 25(11)
Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter and neurotrophin receptor localization and function. These bioc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d80b14e29943670e97da57f1aea92f22
https://pubmed.ncbi.nlm.nih.gov/36304124
https://pubmed.ncbi.nlm.nih.gov/36304124
Autor:
Jennifer L. Sanderson, Ronald K. Freund, Anna M. Castano, Timothy A. Benke, Mark L. Dell’Acqua
Publikováno v:
Neuropharmacology. 220:109271
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7c42c68252672dd38001c603be77f1
https://doi.org/10.1016/j.neuropharm.2022.109271
https://doi.org/10.1016/j.neuropharm.2022.109271
Autor:
Emily Sullivan, Huntington Potter, Olga Prikhodko, Md. Mahiuddin Ahmed, Noah R. Johnson, Heidi J. Chial, Mark L. Dell'Acqua, Esteban M. Lucero, Breanna Dooling, Ronald K. Freund
Competitive inhibition of kinesin motor proteins by amyloid-beta (Aβ) may contribute to alterations in the neuronal microtubule cytoskeleton that can disrupt plasticity mechanisms required for learning and memory, such as long-term potentiation (LTP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88d7b1572b71a752d572749f6c14b90b
https://doi.org/10.1101/2021.09.09.459627
https://doi.org/10.1101/2021.09.09.459627
Publikováno v:
Cell reports
Cell Reports, Vol 37, Iss 1, Pp 109786-(2021)
Cell Reports, Vol 37, Iss 1, Pp 109786-(2021)
SUMMARY Regulated insertion and removal of postsynaptic AMPA glutamate receptors (AMPARs) mediates hippocampal long-term potentiation (LTP) and long-term depression (LTD) synaptic plasticity underlying learning and memory. In Alzheimer’s disease β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ddbacd231890a7c92aaf04eb07b508c
http://europepmc.org/articles/PMC8530450
http://europepmc.org/articles/PMC8530450
Autor:
Mark L. Dell'Acqua, Sharon L. Graw, Karen E. Stevens, Sherry Leonard, Kevin S. Choo, Ronald K. Freund
Publikováno v:
Neuroscience Letters. 627:1-6
Reduced α7 nicotinic acetylcholine receptor (nAChR) function is linked to impaired hippocampal-dependent sensory processing and learning and memory in schizophrenia. While knockout of the Chrna7 gene encoding the α7nAChR on a C57/Bl6 background res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25a886a01a201c195bdd449d4564df37
https://doi.org/10.1016/j.neulet.2016.05.043
https://doi.org/10.1016/j.neulet.2016.05.043