Výsledky vyhledávání - "Ronald K Blackman"

Akademický článek

Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Autor: Ronald K Blackman, Kahlin Cheung-Ong, Marinella Gebbia, David A Proia, Suqin He, Jane Kepros, Aurelie Jonneaux, Philippe Marchetti, Jerome Kluza, Patricia E Rao, Yumiko Wada, Guri Giaever, Corey Nislow

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e29798 (2012)

Elesclomol is a first-in-class investigational drug currently undergoing clinical evaluation as a novel cancer therapeutic. The potent antitumor activity of the compound results from the elevation of reactive oxygen species (ROS) and oxidative stress

Externí odkaz: https://doaj.org/article/5e320c1365494d17bd927ce04f47a8c1

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Akademický článek

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

Autor: David A Proia, Kevin P Foley, Tim Korbut, Jim Sang, Don Smith, Richard C Bates, Yuan Liu, Alex F Rosenberg, Dan Zhou, Keizo Koya, James Barsoum, Ronald K Blackman

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18552 (2011)

There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinase

Externí odkaz: https://doaj.org/article/5f8979a9202f493f95717a8dd14439d5

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