Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Ronald Kühne"'
Autor:
Sai Prasanna Visweshwaran, Hafiza Nayab, Lennart Hoffmann, Marine Gil, Fan Liu, Ronald Kühne, Tanja Maritzen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
As sentinels of our immune system dendritic cells (DCs) rely on efficient cell migration for patrolling peripheral tissues and delivering sampled antigens to secondary lymphoid organs for the activation of T-cells. Dynamic actin polymerization is key
Externí odkaz:
https://doaj.org/article/3c7919df9cb14bd29f6bf651adf8ed9c
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 884-889 (2012)
Photoswitchable click amino acids (PSCaa) are amino acids bearing a side chain consisting of a photoswitchable unit elongated with a functional group that allows for a specific click reaction, such as an alkene that can react with the thiol group of
Externí odkaz:
https://doaj.org/article/ec1ad44b2b034fc08750002c3469f3d9
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36948 (2012)
Peptide ligands of G protein-coupled receptors constitute valuable natural lead structures for the development of highly selective drugs and high-affinity tools to probe ligand-receptor interaction. Currently, pharmacological and metabolic modificati
Externí odkaz:
https://doaj.org/article/0805680bab184e97b215ad6c2f0cb4f2
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50350 (2012)
The primary gestagen of elephants is 5α-dihydroprogesterone (DHP), which is unlike all other mammals studied until now. The level of DHP in elephants equals that of progesterone in other mammals, and elephants are able to bind DHP with similar affin
Externí odkaz:
https://doaj.org/article/4904019e1c8b43108b08311d0e7f58c3
Autor:
Jörg D Wichard, Antonius Ter Laak, Gerd Krause, Nikolaus Heinrich, Ronald Kühne, Gunnar Kleinau
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16811 (2011)
Understanding the molecular mechanism of signalling in the important super-family of G-protein-coupled receptors (GPCRs) is causally related to questions of how and where these receptors can be activated or inhibited. In this context, it is of great
Externí odkaz:
https://doaj.org/article/12493d5d5efe49d4a6196f79c7f86438
Autor:
Bernd Rupp, Sebastian Günther, Talat Makhmoor, Andreas Schlundt, Katharina Dickhaut, Shashank Gupta, Iqbal Choudhary, Karl-Heinz Wiesmüller, Günther Jung, Christian Freund, Kirsten Falk, Olaf Rötzschke, Ronald Kühne
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18662 (2011)
MHC class II molecules (MHC II) play a pivotal role in the cell-surface presentation of antigens for surveillance by T cells. Antigen loading takes place inside the cell in endosomal compartments and loss of the peptide ligand rapidly leads to the fo
Externí odkaz:
https://doaj.org/article/30542512870d4e678ad330090dc27fc1
Autor:
Shashank Gupta, Sabine Höpner, Bernd Rupp, Sebastian Günther, Katharina Dickhaut, Noopur Agarwal, M Cristina Cardoso, Ronald Kühne, Karl-Heinz Wiesmüller, Günther Jung, Kirsten Falk, Olaf Rötzschke
Publikováno v:
PLoS ONE, Vol 3, Iss 3, p e1814 (2008)
Class II MHC molecules display peptides on the cell surface for the surveillance by CD4+ T cells. To ensure that these ligands accurately reflect the content of the intracellular MHC loading compartment, a complex processing pathway has evolved that
Externí odkaz:
https://doaj.org/article/31357325989b4a0f9c3a15d54040560a
Publikováno v:
Organicbiomolecular chemistry. 20(47)
The geometrically defined XPP tripeptide analogue ProM-19 was stereoselectively synthesized and converted into a potential EVH1 ligand by peptide synthesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3349fad7300e1ecf07f789827bfa6791
https://pubmed.ncbi.nlm.nih.gov/36385673
https://pubmed.ncbi.nlm.nih.gov/36385673
Autor:
Pascal M. Engelhardt, Sebastián Florez‐Rueda, Marco Drexelius, Jörg‐Martin Neudörfl, Daniel Lauster, Christian P. R. Hackenberger, Ronald Kühne, Ines Neundorf, Hans‐Günther Schmalz
Publikováno v:
ChemBioChem. 23
During viral cell entry, the spike protein of SARS-CoV-2 binds to the α1-helix motif of human angiotensin-converting enzyme 2 (ACE2). Thus, alpha-helical peptides mimicking this motif may serve as inhibitors of viral cell entry. For this purpose, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb40032a36c555a12b536d92175a754
https://doi.org/10.1002/cbic.202200372
https://doi.org/10.1002/cbic.202200372
Autor:
Stephan Dohmen, Martin Reiher, Ronald Kühne, Dominik Albat, Jörg-Martin Neudörfl, Matthias Barone, Sema Akyol, Hans-Günther Schmalz
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
A general and powerful method for the stereo‐controlled Pd‐catalyzed N‐allylation of amino acid esters is reported, as a previously largely unsolved synthetic challenge. Employing a new class of tartaric acid‐derived C 2‐symmetric chiral di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f86ced86041ba4a0efbbdfc0dc8bb76
https://doi.org/10.1002/chem.202000307
https://doi.org/10.1002/chem.202000307