Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Ronald J. Sawchuk"'
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 71:373-383
Linking biomarker data to pharmacokinetic (PK) models permits comparison of absorbed dose with a toxicological benchmark, which is an important step to understanding the health implications of pesticide exposure. The purpose of this analysis was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc542f1e74e9f941cb954559ffa351fc
https://doi.org/10.1080/15287390701801638
https://doi.org/10.1080/15287390701801638
Autor:
Janel Long, John Rogosheske, Juki Ng, Kathleen Green, Pamala A. Jacobson, Rory P. Remmel, Ye Tan, Daniel J. Weisdorf, Ronald J. Sawchuk, Philip B. McGlave, Juliet N. Barker
Publikováno v:
Clinical Pharmacology & Therapeutics. 78:486-500
Mycophenolate mofetil is used increasingly to provide immunosuppression after nonmyeloablative allogeneic hematopoietic cell transplantation. There is wide variability in the pharmacokinetics of mycophenolic acid (MPA), the active metabolite, and low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64308f8ded933ebd30b0c8814eef6cc2
https://doi.org/10.1016/j.clpt.2005.08.009
https://doi.org/10.1016/j.clpt.2005.08.009
Publikováno v:
Fundamental and Clinical Pharmacology. 19:347-354
For high-throughput screening in drug development, methods that can reduce analytical work are desirable. Pooling of plasma samples from an individual subject in the time domain to yield a single sample for analysis has been used to estimate the area
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5773eec985148112e528121e4ebdd982
https://doi.org/10.1111/j.1472-8206.2005.00329.x
https://doi.org/10.1111/j.1472-8206.2005.00329.x
Publikováno v:
Journal of Pharmaceutical Sciences. 92:1947-1956
This study was conducted to determine cefditoren (CDTR) transport kinetics between plasma and middle ear fluid (MEF) by characterizing influx ( CL in) and efflux ( CL out) clearances expressed in terms of unbound concentrations and their ratio. Simul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1050f4cc9095ab7402fc99f4d74705
https://doi.org/10.1002/jps.10457
https://doi.org/10.1002/jps.10457
Publikováno v:
Journal of Pharmaceutical Sciences. 91:217-228
The purpose of this study was to characterize the pharmacokinetics and dose proportionality of the prokinetic macrolide, EM574, in rabbits following intravenous dosing, and to determine the intestinal absorption and intestinal and hepatic first‐pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70fdd613bc7f6ba3968ae547310dfab
https://doi.org/10.1002/jps.10002
https://doi.org/10.1002/jps.10002
Microdialysis studies of the middle ear distribution kinetics of amoxicillin in the awake chinchilla
Publikováno v:
Journal of Pharmaceutical Sciences. 90:2088-2098
This work was performed to develop an experimental animal model for the study of antibiotic drug distribution into middle ear fluid (MEF) and to evaluate its relevance and significance to the clinical treatment of otitis media (OM). Chinchillas were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acade02787afdd20e92aa7f62ac99970
https://doi.org/10.1002/jps.1159
https://doi.org/10.1002/jps.1159
Autor:
William F. Elmquist, Ronald J. Sawchuk
Publikováno v:
Advanced Drug Delivery Reviews. 45:295-307
Quantitative microdialysis in the central nervous system (CNS) has recently provided evidence for the existence of transporters as they relate to the brain distribution of a variety of drugs. Support for the existence of drug transporters in the bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257799113c6dc86888c27cab7109c1be
https://doi.org/10.1016/s0169-409x(00)00104-6
https://doi.org/10.1016/s0169-409x(00)00104-6
Autor:
Lillian E. Riad, Ronald J. Sawchuk
Publikováno v:
Journal of Pharmaceutical Sciences. 87:769-773
The true elimination rate constant of a metabolite is calculated using a partial area difference analysis. A linear pharmacokinetic model which describes clearances of parent and metabolite is developed. The model makes no restrictions on the route o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab128263f76c4a2f56574fb4ce1d8d35
https://doi.org/10.1021/js970321h
https://doi.org/10.1021/js970321h
Publikováno v:
Journal of Drug Targeting. 4:277-288
EAB 515 (S-alpha-amino-5-phosphonomethyl[1,1'biphenyl]-3-propanoic acid) is an extremely hydrophilic N-methyl-D-aspartate antagonist. It shows marked CNS activity, in that it is a potent neuroprotector in models of cerebral ischemia, and also demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203f3316f8b1431d4cce41ae13ae26a6
https://doi.org/10.3109/10611869708995843
https://doi.org/10.3109/10611869708995843