Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ronald J. Rahaim"'
Autor:
Clara Penas, Eve-Ellen Govek, Yin Fang, Vimal Ramachandran, Mark Daniel, Weiping Wang, Marie E. Maloof, Ronald J. Rahaim, Mathieu Bibian, Daisuke Kawauchi, David Finkelstein, Jeng-Liang Han, Jun Long, Bin Li, David J. Robbins, Marcos Malumbres, Martine F. Roussel, William R. Roush, Mary E. Hatten, Nagi G. Ayad
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 249-260 (2015)
Although casein kinase 1δ (CK1δ) is at the center of multiple signaling pathways, its role in the expansion of CNS progenitor cells is unknown. Using mouse cerebellar granule cell progenitors (GCPs) as a model for brain neurogenesis, we demonstrate
Externí odkaz:
https://doaj.org/article/2151b5d008f24920a38f942f1ddc596a
Publikováno v:
ACS Catalysis. 8:4539-4544
Herein, we report the development of a dual catalytic approach for the cross-coupling of nitriles with aryl- and aliphatic-bromides. A titanium(III) catalyst is used to activate nitriles enabling their coupling with organobromides through a nickel ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a84e21f1d3ab36cb60cb772e25b3667
https://doi.org/10.1021/acscatal.8b00244
https://doi.org/10.1021/acscatal.8b00244
Publikováno v:
Tetrahedron Letters. 61:151729
A nickel-catalyzed cross-electrophile coupling of benzyl alcohols with aromatic bromides has been developed. This deoxygenative cross-coupling occurs under mild reaction conditions at ambient temperature affording diarylmethanes, or 1,3-diarylpropene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11d75cc5fe6d74bbb1cc73dfd23ba01
https://doi.org/10.1016/j.tetlet.2020.151729
https://doi.org/10.1016/j.tetlet.2020.151729
Autor:
Sajan Silwal, Ronald J. Rahaim
Publikováno v:
Tetrahedron Letters. 56:5738-5742
A method for the modular one-pot synthesis of tetra-substituted furans utilizing alkynes, Weinreb amides, and non-enolizable aldehydes has been developed. Under this titanium promoted method, furans were prepared in moderate yields with high levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b3461e41de0ad2b59c8abafb8359faf
https://doi.org/10.1016/j.tetlet.2015.09.021
https://doi.org/10.1016/j.tetlet.2015.09.021
Autor:
Daisuke Kawauchi, William R. Roush, Vimal Ramachandran, Yin Fang, Clara Penas, David Finkelstein, David J. Robbins, Marcos Malumbres, Ronald J. Rahaim, Mary E. Hatten, Weiping Wang, Marie E. Maloof, Bin Li, Jeng Liang Han, Mathieu Bibian, Jun Long, Eve-Ellen Govek, Nagi G. Ayad, Mark Daniel, Martine F. Roussel
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports, Vol 11, Iss 2, Pp 249-260 (2015)
Instituto de Salud Carlos III (ISCIII)
Cell Reports, Vol 11, Iss 2, Pp 249-260 (2015)
Although casein kinase 1δ (CK1δ) is at the center of multiple signaling pathways, its role in the expansion of CNS progenitor cells is unknown. Using mouse cerebellar granule cell progenitors (GCPs) as a model for brain neurogenesis, we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfccb85b1d5af51bcc04fd62134e5063
Autor:
Sajan Silwal, Ronald J. Rahaim
Publikováno v:
The Journal of Organic Chemistry. 79:8469-8476
A modular titanium-promoted coupling of unsymmetrical internal alkynes with Weinreb amides is described. The coupling reaction takes place at room temperature and affords E-trisubstituted enones in moderate to good yields with high levels of regiosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a074f5a935724bc8d82ec130a494cb4
https://doi.org/10.1021/jo5014417
https://doi.org/10.1021/jo5014417
Autor:
Ronald J. Rahaim, Yoshihiko Noguchi, Yangbo Feng, Shima Nakanishi, Lin Li, Konstantin Licht, Laura H. Rosenberg, Weimin Chen, John L. Cleveland, Stephan C. Schürer, William R. Roush, Jun Yong Choi, Michael D. Cameron, Mathieu Bibian, Derek R. Duckett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4374-4380
The development of a series of potent and highly selective casein kinase 1δ/e (CK1δ/e) inhibitors is described. Starting from a purine scaffold inhibitor (SR-653234) identified by high throughput screening, we developed a series of potent and highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605695bf6443d3205752074bd96d5714
https://doi.org/10.1016/j.bmcl.2013.05.075
https://doi.org/10.1016/j.bmcl.2013.05.075
Publikováno v:
Organic letters. 18(19)
α,β-Unsaturated amides are important building blocks and are key structural elements in a number of biologically active natural products. Despite their importance and prevalence, few methods exist to prepare conjugated amides directly and modularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e741fab9eefb03336ff045791bb6391f
https://pubmed.ncbi.nlm.nih.gov/27678270
https://pubmed.ncbi.nlm.nih.gov/27678270
Autor:
Sajan Silwal, Ronald J. Rahaim
Publikováno v:
ChemInform. 47
The three-component one-pot reaction proceeds with high levels of regioselectivity and tolerates a wide range of functional groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c9a000e4706ef76fc614d1ecb63d52
https://doi.org/10.1002/chin.201608120
https://doi.org/10.1002/chin.201608120
Autor:
Ronald J. Rahaim, Robert E. Maleczka
Publikováno v:
Organic Letters. 13:584-587
Catalytic Pd(OAc)(2) and polymethylhydrosiloxane (PMHS), in conjunction with aqueous KF, and a catalytic amount of an aromatic chloride, effects the chemo-, regio-, and stereoselective deoxygenation of benzylic oxygenated substrates at room temperatu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79b414628cd31465179704ed2d8e5c36
https://doi.org/10.1021/ol102757v
https://doi.org/10.1021/ol102757v