Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Ronald J. Gerson"'
Autor:
Lawrence Friedhoff, Dominique Paquette, Holger Weis, Simon Authier, Joseph C. Arezzo, Michael V. Accardi, Mylene Pouliot, Ronald J. Gerson, R. John Stubbs
Publikováno v:
Journal of pharmacological and toxicological methods. 81
Introduction Continuous video-electroencephalographic (EEG) monitoring remains the gold standard for seizure liability assessments in preclinical drug safety assessments. EEG monitored by telemetry was used to assess the behavioral and EEG effects of
Autor:
Jay I. Goodman, Richard D. Storer, Peter Kasper, Douglas A. Keller, Abigail Jacobs, Ronald J. Gerson, Gerald G. Long, John E. French, Tohru Inoue, Amy L. Lavin, James S. MacDonald, Bruce McCullough, Frank D. Sistare, Jan Willem van der Laan
Publikováno v:
Toxicological Sciences. 77:188-194
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Autor:
Bernard Leblanc, Thomas A. Baillie, Hassan G. Fouda, Lisa A. Shipley, Scott J. Grossman, James D. Green, Ronald J. Gerson, Darcy G. Perkins, Lewis J. Klunk, Mitchell N. Cayen
Publikováno v:
Toxicology and Applied Pharmacology. 182:188-196
This report summarizes the deliberations of a multidisciplinary committee, sponsored by the Pharmaceutical Research and Manufacturers of America, on current "best practices" within the U.S. pharmaceutical industry in assessing the role of drug metabo
Publikováno v:
Birth defects research. Part B, Developmental and reproductive toxicology. 83(1)
BACKGROUND: Endogenous opioids seem to regulate hypothalamic gonadotropin release in both males and females, as evidenced by the effects of opioid agonists and antagonists on LHRH release and reproductive hormone levels. The effects of long-term oral
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 95(2)
Oxymorphone is a potent opioid analgesic. Oral administration of oxymorphone to rats at doses >or= 20 mg/kg and mice at 500 mg/kg produced an increase in micronucleated polychromatic erythrocytes (MPCEs). Oxymorphone does not produce chromosome aberr
Autor:
James, MacDonald, John E, French, Ronald J, Gerson, Jay, Goodman, Tohru, Inoue, Abigail, Jacobs, Peter, Kasper, Douglas, Keller, Amy, Lavin, Gerald, Long, Bruce, McCullough, Frank D, Sistare, Richard, Storer, Jan Willem, van der Laan
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 77(2)
The Alternatives to Carcinogenicity Testing Committee of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) conducted a large-scale, multinational collaborative research program to evaluate several gen
Autor:
David D. Christ, Lawrence S. Gan, Richard T. Robertson, Gerald T. Miwa, Marc H. Davies, Abdul E. Mutlib, Patrick J. Haley, Brian Gemzik, Paul Meunier, Jay A. Markwalder, Steven P. Seitz, Ronald J. Gerson, David F. Krahn, Hao Chen
Publikováno v:
Toxicology and applied pharmacology. 169(1)
Efavirenz, a potent nonnucleoside reverse transcriptase inhibitor widely prescribed for the treatment of HIV infection, produces renal tubular epithelial cell necrosis in rats but not in cynomolgus monkeys or humans. This species selectivity in nephr
Autor:
Peter F. Smith, Ronald J. Gerson, Regina W. Wang, Lea R. Gordon, Scott J. Grossman, John I. Germershausen, James A. Majka, John G. DeLuca, James S. MacDonald
Publikováno v:
Toxicologic pathology. 19(3)
Female Sprague-Dawley rats were treated with either simvastatin (a novel competitive inhibitor of HMG CoA reductase) or phcnobarbilal (positive control) to ascertain the possible relationship between the effects of simvastatin on hepatic metabolism a
Publikováno v:
Toxicological Sciences; Mar2007, Vol. 96 Issue 1, p162-173, 12p
Publikováno v:
Toxicological Sciences; Feb2007, Vol. 95 Issue 2, p369-375, 7p