Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ronald J. Gathagan"'
Autor:
Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk
Publikováno v:
Neurobiology of Disease, Vol 136, Iss , Pp 104712- (2020)
Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there is
Externí odkaz:
https://doaj.org/article/2065928935b24bed8f41f6623a293ece
Publikováno v:
Neurobiology of Disease, Vol 109, Iss , Pp 209-218 (2018)
The deposition of misfolded β-sheet enriched amyloid protein is a shared feature of many neurodegenerative diseases. Recent studies demonstrated the existence of conformationally diverse strains as a common property for multiple amyloidogenic protei
Externí odkaz:
https://doaj.org/article/df339b641f104b74bb53a9f820d52482
Autor:
Shujing Zhang, Ruowei Zhu, Buyan Pan, Hong Xu, Modupe F. Olufemi, Ronald J. Gathagan, Yuanxi Li, Luyan Zhang, Jasmine Zhang, Wenxuan Xiang, Eliot Masahiro Kagan, Xingjun Cao, Chaoxing Yuan, Soo-Jung Kim, Christopher K. Williams, Shino Magaki, Harry V. Vinters, Hilal A. Lashuel, Benjamin A. Garcia, E. James Petersson, John Q. Trojanowski, Virginia M.-Y. Lee, Chao Peng
Publikováno v:
Nature neuroscience, vol 26, iss 2
Cell-to-cell transmission and subsequent amplification of pathological proteins promote neurodegenerative disease progression. Most research on this has focused on pathological protein seeds, but how their normal counterparts, which are converted to
Autor:
Ronald J. Gathagan, Hannah J. Brown, Virginia M.-Y. Lee, John Q. Trojanowski, Michael X. Henderson, Modupe F. Olufemi, Bin Zhang, Eli J. Cornblath, Danielle S. Bassett, Lakshmi Changolkar, Howard L. Li
Publikováno v:
Science Advances
Spread of tau pathology follows brain connectivity, is modulated by selective vulnerability, and is predicted by network analysis.
Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s dis
Neuropathological staging studies have suggested that tau pathology spreads through the brain in Alzheimer’s dis
Autor:
Ronald J. Gathagan, Virginia M.-Y. Lee, Adam Darwich, Eli J. Cornblath, Michael X. Henderson, Bin Zhang, Raizel M. Sandler, Hannah J. Brown, John Q. Trojanowski, Danielle S. Bassett
Publikováno v:
Nature Neuroscience. 22:1248-1257
Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins spread through the brain along anatomically connected networks, prompting progressive decline. Recently, mouse models have recapitulated the cell-to-cell tran
Autor:
Danielle S. Bassett, Eli J. Cornblath, Modupe F. Olufemi, Virginia M.-Y. Lee, Hannah J. Brown, Ronald J. Gathagan, John Q. Trojanowski, Howard L. Li, Michael X. Henderson, Bin Zhang, Lakshmi Changolkar
Tau pathology is a diagnostic feature of Alzheimer’s disease (AD) but is also a prominent feature of Parkinson’s disease (PD), including genetic forms of PD with mutations in leucine-rich repeat kinase 2 (LRRK2). In both diseases, tau pathology i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcff844c00f55167b4b742010afef618
https://doi.org/10.1101/2020.10.13.337857
https://doi.org/10.1101/2020.10.13.337857
Autor:
Dustin J. Covell, Rose M. Pitkin, Samantha C. Decker, Ronald J. Gathagan, Virginia M.-Y. Lee, Kelvin C. Luk, John Q. Trojanowski, Charlotte Hiu-Yan Chung, Kurt R. Brunden, Michael X. Henderson, Dawn M. Riddle, Raizel M. Sandler, Michael J. James, Bin Zhang
Publikováno v:
Neurobiology of Disease, Vol 136, Iss, Pp 104712-(2020)
Neurobiol Dis
Neurobiol Dis
Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are progressive neurodegenerative diseases for which there is no disease-modifying treatment. PD and DLB are characterized by aggregation of the synaptic protein α-synuclein, and there i
Autor:
Virginia M.-Y. Lee, Modupe F. Olufemi, Anna Stieber, John Q. Trojanowski, Bin Zhang, Rose M. Pitkin, Chao Peng, Kelvin C. Luk, Dustin J. Covell, John L. Robinson, Ronald J. Gathagan, Coraima Medellin
Publikováno v:
Nature
In Lewy body diseases-including Parkinson's disease, without or with dementia, dementia with Lewy bodies, and Alzheimer's disease with Lewy body co-pathology 1 -α-synuclein (α-Syn) aggregates in neurons as Lewy bodies and Lewy neurites 2 . By contr
Autor:
Zhuohao He, Kurt R. Brunden, Ted Abel, Jennifer D. McBride, Sneha Narasimhan, Magdalena Nitla, Lakshmi Changolkar, Jing L. Guo, Ronald J. Gathagan, John Q. Trojanowski, Hyesung Kim, Virginia M.-Y. Lee, Douglas A. Coulter, Anna Stieber, Cuiyong Yue, Bin Zhang, Christopher G. Dengler
Publikováno v:
Nature Medicine. 24:29-38
Alzheimer’s disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and intracellular tau inclusions. However, the exact mechanistic link between these two AD lesions remains enigmatic. Through injection of human AD-brain-derived pa
Autor:
Luisa Victoria Silva, Lakshmi Changolkar, Zhuohao He, Jing L. Guo, Jennifer D. McBride, Anna Stieber, Virginia M.-Y. Lee, Bin Zhang, Sneha Narasimhan, Ronald J. Gathagan, John Q. Trojanowski
Publikováno v:
The Journal of Neuroscience. 37:11406-11423
Pathological tau aggregates occur in Alzheimer's disease (AD) and other neurodegenerative tauopathies. It is not clearly understood why tauopathies vary greatly in the neuroanatomical and histopathological patterns of tau aggregation, which contribut