Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ronald J. Bopp"'
Autor:
Bettina Pahlen, John F. Stobaugh, Ronald J. Bopp, Kerri L. Chetwyn, David J. Skanchy, Eugene C. Rickard
Publikováno v:
Chirality. 8:108-121
In the past several years, capillary electrophoresis (CE) has generated considerable interest from pharmaceutical companies for control of both the chiral and achiral purity of bulk drugs and drug products. This paper evaluates the use of CE as: (1)
Autor:
Ronald J. Bopp, Eugene C. Rickard
Publikováno v:
Journal of Chromatography A. 680:609-621
Capillary electrophoresis (CE) using hydroxypropyl-β-cyclodextrin (HP-β-CD) in the separation buffer was investigated to determine the overall chiral purity of a drug containing a single stereogenic center. The effects of primary factors —pH, buf
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 9:363-382
In the pharmaceutical industry, chiral drug candidates introduce a unique set of challenges to all disciplines involved in the drug development process. For the analytical chemist in particular, the generation of relevant information about a variety
Publikováno v:
Clinical Pharmacology and Therapeutics. 43:688-695
To test the hypothesis that renal insufficiency alters nizatidine disposition, we determined the pharmacokinetics of nizatidine and its major metabolite after a single oral dose in normal volunteers and patients with various degrees of renal dysfunct
Autor:
David J. Miner, Ronald J. Bopp
Publikováno v:
Journal of Pharmaceutical Sciences. 71:1402-1406
A simple and specific method has been developed for determination of enviroxime in biological samples. Enviroxime, a substituted benzimidazole, its coisomer zinviroxime, and the internal standard hexestrol were extracted from the samples with benzene
Publikováno v:
Journal of Pharmaceutical Sciences. 74:846-850
A rapid and specific high-performance liquid chromatographic (HPLC) assay has been developed for the determination of enviradene, 1, at concentrations of 2-5 ng/mL in plasma. The drug was extracted from the samples using benzene. The benzene extract
Publikováno v:
The Journal of Organic Chemistry. 34:3574-3578
Autor:
Douglas E. Dillard, Rajaninath J. Kamat, Dhansukh M. Chevli, Ronald J. Bopp, Paul E. Peterson, Edward L. Curran
Publikováno v:
Journal of the American Chemical Society. 89:5902-5911