Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Ronald J van der Sluis"'
1
Akademický článek
Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice.
Autor: Menno Hoekstra, Vanessa Frodermann, Tim van den Aardweg, Ronald J van der Sluis, Johan Kuiper
Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80441 (2013)
Hyperlipidemic apolipoprotein E (APOE) knockout mice show an enhanced level of adrenal-derived anti-inflammatory glucocorticoids. Here we determined in APOE knockout mice the impact of total removal of adrenal function through adrenalectomy (ADX) on
Externí odkaz: https://doaj.org/article/4e3f9b2beb504ed9a0d6acbdecf5d0af
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2
Akademický článek
Metyrapone Treatment Protects Low-Density Lipoprotein Receptor Knockout Mice against Hypercorticosteronemia Development without Changing Atherosclerosis Susceptibility
Autor: Ronald J. van der Sluis, Tim van den Aardweg, Timothy J. P. Sijsenaar, Miranda Van Eck, Menno Hoekstra
Publikováno v: Biomolecules, Vol 13, Iss 9, p 1287 (2023)
The steroid 11beta-hydroxylase inhibitor metyrapone is able to effectively reverse the hypercortisolemia detected in human Cushing’s Syndrome patients. In this current preclinical study, we investigated whether metyrapone monotherapy can also rever
Externí odkaz: https://doaj.org/article/21c69ebc2045410995388d56d0e55659
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3
Akademický článek
A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function
Autor: Jan Kroon, Maaike Schilperoort, Wietse In het Panhuis, Rosa van den Berg, Lotte van Doeselaar, Cristy R.C. Verzijl, Nikki van Trigt, Isabel M. Mol, Hetty H.C.M. Sips, Jose K. van den Heuvel, Lisa L. Koorneef, Ronald J. van der Sluis, Anna Fenzl, Florian W. Kiefer, Sabine Vettorazzi, Jan P. Tuckermann, Nienke R. Biermasz, Onno C. Meijer, Patrick C.N. Rensen, Sander Kooijman
Publikováno v: Molecular Metabolism, Vol 47, Iss , Pp 101179- (2021)
Objective: Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) u
Externí odkaz: https://doaj.org/article/1ca61bd60fff4069a39d7542195ccab5
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4
Akademický článek
Bone Marrow Ts65Dn Trisomy-Induced Changes in Platelet Functionality and Lymphocytopenia Do Not Impact Atherosclerosis Susceptibility in Mice
Autor: Suzanne J. A. Korporaal, Ronald J. van der Sluis, Miranda Van Eck, Menno Hoekstra
Publikováno v: Journal of Cardiovascular Development and Disease, Vol 8, Iss 9, p 110 (2021)
The genetic disorder Down syndrome is associated with a decreased susceptibility for atherosclerotic cardiovascular disease. Hematological and immune abnormalities occur frequently in Down syndrome patients. We evaluated, in a preclinical setting, th
Externí odkaz: https://doaj.org/article/4a3ed1ce072a438499c8533aece40bec
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5
Akademický článek
LCAT deficiency in mice is associated with a diminished adrenal glucocorticoid function
Autor: Menno Hoekstra, Suzanne J.A. Korporaal, Ronald J. van der Sluis, Veronica Hirsch-Reinshagen, Andrea E. Bochem, Cheryl L. Wellington, Theo J.C. Van Berkel, Jan Albert Kuivenhoven, Miranda Van Eck
Publikováno v: Journal of Lipid Research, Vol 54, Iss 2, Pp 358-364 (2013)
In vitro studies have suggested that HDL and apoB-containing lipoproteins can provide cholesterol for synthesis of glucocorticoids. Here we assessed adrenal glucocorticoid function in LCAT knockout (KO) mice to determine the specific contribution of
Externí odkaz: https://doaj.org/article/6fcb5206da854ef79fc2971279a3e432
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6
Bone Marrow Ts65Dn Trisomy-Induced Changes in Platelet Functionality and Lymphocytopenia Do Not Impact Atherosclerosis Susceptibility in Mice
Autor: Ronald J. van der Sluis, Miranda Van Eck, Menno Hoekstra, Suzanne J.A. Korporaal
Publikováno v: Journal of Cardiovascular Development and Disease; Volume 8; Issue 9; Pages: 110
Journal of Cardiovascular Development and Disease, Vol 8, Iss 110, p 110 (2021)
Journal of Cardiovascular Development and Disease, 8(9)
Journal of Cardiovascular Development and Disease
The genetic disorder Down syndrome is associated with a decreased susceptibility for atherosclerotic cardiovascular disease. Hematological and immune abnormalities occur frequently in Down syndrome patients. We evaluated, in a preclinical setting, th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5c44a9642ff9d82415ff3c5593e39c
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7
SR-BI deficiency disassociates obesity from hepatic steatosis and glucose intolerance development in high fat diet-fed mice
Autor: Amber B. Ouweneel, Joya E. Nahon, Janine J. Geerling, Ronald J. van der Sluis, Rick van der Geest, Juliet Price, Miranda Van Eck, Menno Hoekstra
Publikováno v: Journal of Nutritional Biochemistry, 89, 108564
Scavenger receptor BI (SR-BI) has been suggested to modulate adipocyte function. To uncover the potential relevance of SR-BI for the development of obesity and associated metabolic complications, we compared the metabolic phenotype of wild-type and S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747daeaa5f94a2da4da4f21475cbdc80
https://doi.org/10.1016/j.jnutbio.2020.108564
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8
A physiological glucocorticoid rhythm is an important regulator of brown adipose tissue function
Autor: Wietse In het Panhuis, Isabel M. Mol, Maaike Schilperoort, Rosa van den Berg, José K. van den Heuvel, Cristy R.C. Verzijl, Onno C. Meijer, Nienke R. Biermasz, Lisa L. Koorneef, Sabine Vettorazzi, Jan Tuckermann, Nikki van Trigt, Ronald J. van der Sluis, Patrick C.N. Rensen, Jan Kroon, Hetty C M Sips, Florian W. Kiefer, Sander Kooijman, Lotte van Doeselaar, Anna Fenzl
Publikováno v: MOLECULAR METABOLISM, 47. ELSEVIER
Molecular Metabolism
Molecular Metabolism, Vol 47, Iss, Pp 101179-(2021)
Objective Brown adipose tissue (BAT) displays a strong circadian rhythm in metabolic activity, but it is unclear how this rhythm is regulated. As circulating levels of corticosterone coincide with the rhythm of triglyceride-derived fatty acid (FA) up
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e7e537823eb01e9efb304237c64cdd0
https://doi.org/10.1016/j.molmet.2021.101179
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10
Disruption of PLTP (phospholipid transfer protein)-mediated HDL (high-density lipoprotein) maturation reduces SR-BI (scavenger receptor BI) deficiency-driven atherosclerosis susceptibility despite unexpected metabolic complications
Autor: Reeni B. Hildebrand, Domenico Praticò, Bart Lammers, Sander Kooijman, Miranda Van Eck, Patrick C.N. Rensen, Theo J.C. Van Berkel, Ying Zhao, Menno Hoekstra, Ronald J. van der Sluis, Matti Jauhiainen
Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 40(3), 611-623
Arteriosclerosis, Thrombosis, and Vascular Biology
Arteriosclerosis, Thrombosis, and Vascular Biology, 40(3), 611-623. LIPPINCOTT WILLIAMS & WILKINS
Objective: We tested the hypothesis that enlarged, dysfunctional HDL (high-density lipoprotein) particles contribute to the augmented atherosclerosis susceptibility associated with SR-BI (scavenger receptor BI) deficiency in mice. Approach and Result
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b87441fe2a5274bfbb58ca44f68125
http://hdl.handle.net/1887/3188385
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