Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Ronald J Vagnozzi"'
Autor:
Jacob T. Gafranek, Enrico D’Aniello, Padmapriyadarshini Ravisankar, Kairavee Thakkar, Ronald J. Vagnozzi, Hee-Woong Lim, Nathan Salomonis, Joshua S. Waxman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract How two-chambered hearts in basal vertebrates have evolved from single-chamber hearts found in ancestral chordates remains unclear. Here, we show that the teleost sinus venosus (SV) is a chamber-like vessel comprised of an outer layer of smo
Externí odkaz:
https://doaj.org/article/b0650cc63eed4e918d41e22172078a89
Autor:
Ronald J. Vagnozzi
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 2, Iss , Pp 100022- (2022)
Externí odkaz:
https://doaj.org/article/c399881fbad94f66b38eee03e8b47fe9
Autor:
Stephanie L. K. Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
Publikováno v:
Cells, Vol 12, Iss 17, p 2174 (2023)
Rationale: The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I collagen also provides an organizational platform for other
Externí odkaz:
https://doaj.org/article/bc1cebba95e0499bb087b9d6cd86552f
Autor:
Tobias Weinberger, Dena Esfandyari, Denise Messerer, Gulce Percin, Christian Schleifer, Raffael Thaler, Lulu Liu, Christopher Stremmel, Vanessa Schneider, Ronald J. Vagnozzi, Jennifer Schwanenkamp, Maximilian Fischer, Katrin Busch, Kay Klapproth, Hellen Ishikawa-Ankerhold, Lukas Klösges, Anna Titova, Jeffery D. Molkentin, Yasuhiro Kobayashi, Stefan Engelhardt, Steffen Massberg, Claudia Waskow, Elisa Gomez Perdiguero, Christian Schulz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Arterial macrophages develop from either yolk sac or bone marrow progenitors. Here, the author show that ageing-induced reduction of arterial macrophages is not replenished by bone marrow-derived cells, but under inflammatory conditions circulating m
Externí odkaz:
https://doaj.org/article/9736be91c4674079bfa53c6a81afee95
Autor:
Michael Alexanian, Arun Padmanabhan, Tomohiro Nishino, Joshua G. Travers, Lin Ye, Clara Youngna Lee, Nandhini Sadagopan, Yu Huang, Angelo Pelonero, Kirsten Auclair, Ada Zhu, Barbara Gonzalez Teran, Will Flanigan, Charis Kee-Seon Kim, Koya Lumbao-Conradson, Mauro Costa, Rajan Jain, Israel Charo, Saptarsi M. Haldar, Katherine S. Pollard, Ronald J. Vagnozzi, Timothy A. McKinsey, Pawel F. Przytycki, Deepak Srivastava
Chronic inflammation and tissue fibrosis are common stress responses that worsen organ function, yet the molecular mechanisms governing their crosstalk are poorly understood. In diseased organs, stress-induced changes in gene expression fuel maladapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce3f813f15b68d411cced6b1ab15fc02
https://doi.org/10.1101/2023.01.06.522937
https://doi.org/10.1101/2023.01.06.522937
Autor:
Ilaria Ferrari, Ronald J. Vagnozzi
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:82-88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6140e3287c5379de66c0adad1a38d3a
https://doi.org/10.1016/j.yjmcc.2021.05.013
https://doi.org/10.1016/j.yjmcc.2021.05.013
Autor:
Jennifer Q. Kwong, Xiyuan Lu, Robert N. Correll, Jennifer A. Schwanekamp, Ronald J. Vagnozzi, Michelle A. Sargent, Allen J. York, Jianyi Zhang, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 15-22 (2015)
In the heart, augmented Ca2+ fluxing drives contractility and ATP generation through mitochondrial Ca2+ loading. Pathologic mitochondrial Ca2+ overload with ischemic injury triggers mitochondrial permeability transition pore (MPTP) opening and cardio
Externí odkaz:
https://doaj.org/article/24c55190390241b081190447c3450bdc
Autor:
Timothy A McKinsey, Roger Foo, Chukwuemeka George Anene-Nzelu, Joshua G Travers, Ronald J Vagnozzi, Natalie Weber, Thomas Thum
Publikováno v:
Cardiovasc Res
Cardiovascular diseases and specifically heart failure (HF) impact global health and impose a significant economic burden on society. Despite current advances in standard of care, the risks for death and readmission of HF patients remain unacceptably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4dedd354b349f46d52818fb03020a4f
https://europepmc.org/articles/PMC10202443/
https://europepmc.org/articles/PMC10202443/
Autor:
Nicholas E. Hoffman, Harish C. Chandramoorthy, Santhanam Shamugapriya, Xueqian Zhang, Sudarsan Rajan, Karthik Mallilankaraman, Rajesh Kumar Gandhirajan, Ronald J. Vagnozzi, Lucas M. Ferrer, Krishnalatha Sreekrishnanilayam, Kalimuthusamy Natarajaseenivasan, Sandhya Vallem, Thomas Force, Eric T. Choi, Joseph Y. Cheung, Muniswamy Madesh
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1576-1588 (2013)
Resting mitochondrial matrix Ca2+ is maintained through a mitochondrial calcium uptake 1 (MICU1)-established threshold inhibition of mitochondrial calcium uniporter (MCU) activity. It is not known how MICU1 interacts with MCU to establish this Ca2+ t
Externí odkaz:
https://doaj.org/article/c0a8a3bb30744a0ab88b6a28b151800a
Cardiac fibroblasts regulate cardiomyocyte hypertrophy through dynamic regulation of type I collagen
Autor:
Qinghang Meng, Stephanie L. K. Bowers, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
RationaleCardiomyocytes and fibroblasts in the heart communicate through both secreted growth factors as well as through sensing the structural properties of the extracellular matrix that each helps generate. Previous studies have shown that defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f27790df13357df1234b902ad0d4ec8f
https://doi.org/10.1101/2022.05.25.493406
https://doi.org/10.1101/2022.05.25.493406