RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.

Autor: Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek

Publikováno v: PLoS Pathogens, Vol 13, Iss 11, p e1006738 (2017)

Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here s

Externí odkaz: https://doaj.org/article/8fb71dd840f84d5f831fe88badab0ad3

Genotypic and Phenotypic Characterization of Replication-Competent HIV-2 Isolated from Controllers and Progressors

Autor: Cynthia Lungu, Ronald J. Overmars, Esmée Grundeken, Patrick H. M. Boers, Marchina E. van der Ende, Thibault Mesplède, Rob A. Gruters

Publikováno v: Viruses, Vol 15, Iss 11, p 2236 (2023)

Although some individuals with HIV-2 develop severe immunodeficiency and AIDS-related complications, most may never progress to AIDS. Replication-competent HIV-2 isolated from asymptomatic long-term non-progressors (controllers) have lower replicatio

Externí odkaz: https://doaj.org/article/77e38f7aaf384a6b80059352043cad5b

The BAF complex inhibitor pyrimethamine reverses HIV-1 latency in people with HIV-1 on antiretroviral therapy

Autor: Henrieke A. B. Prins, Raquel Crespo, Cynthia Lungu, Shringar Rao, Letao Li, Ronald J. Overmars, Grigorius Papageorgiou, Yvonne M. Mueller, Mateusz Stoszko, Tanvir Hossain, Tsung Wai Kan, Bart J. A. Rijnders, Hannelore I. Bax, Eric C. M. van Gorp, Jan L. Nouwen, Theodora E. M. S. de Vries-Sluijs, Carolina A. M. Schurink, Mariana de Mendonça Melo, Els van Nood, Angela Colbers, David Burger, Robert-Jan Palstra, Jeroen J. A. van Kampen, David A. M. C. van de Vijver, Thibault Mesplède, Peter D. Katsikis, Rob A. Gruters, Birgit C. P. Koch, Annelies Verbon, Tokameh Mahmoudi, Casper Rokx

Publikováno v: Science Advances, 9
Science Advances, 9, 11
Science advances, 9(11):eade6675. American Association for the Advancement of Science

Contains fulltext : 291084.pdf (Publisher’s version ) (Open Access) Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3887f3da1a82107e3f551dccee2edb
https://doi.org/10.1126/sciadv.ade6675

COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study

Autor: Jaco J. Verweij, Annemiek A. van der Eijk, Anne van der Linden, Anne J.G. van Oudheusden, Theo M. Bestebroer, Marion Koopmans, Jan Kluytmans, Anton Buiting, Reina S. Sikkema, Robbert G. Bentvelsen, David F. Nieuwenhuijse, Stefan van Nieuwkoop, Miranda van Rijen, Pascal Lexmond, Irina Chestakova, Marjolein Kluytmans– van den Bergh, Richard Molenkamp, Ronald J. Overmars, Andrew Rambaut, Suzan D. Pas, Mark Pronk, Aura Timen, Bram M. W. Diederen, Wouter van den Bijllaardt, A.M.C. Bergmans, Áine O'Toole, Bas B. Oude Munnink, Claudia M. E. Schapendonk

Publikováno v: The Lancet Infectious Diseases, 20(11), 1273-1280. Lancet Publishing Group
Sikkema, R S, Pas, S D, Nieuwenhuijse, D F, O'Toole, Á, Verweij, J J, van der Linden, A, Chestakova, I, Schapendonk, C, Pronk, M, Lexmond, P, Bestebroer, T, Overmars, R J, van Nieuwkoop, S, van den Bijllaardt, W, Bentvelsen, R G, van Rijen, M M L, Buiting, A G M, van Oudheusden, A J G, Diederen, B M, Bergmans, A M C, van der Eijk, A, Molenkamp, R, Rambaut, A, Timen, A, Kluytmans, J A J W, Oude Munnink, B B, Kluytmans van den Bergh, M F Q & Koopmans, M P G 2020, ' COVID-19 in health-care workers in three hospitals in the south of the Netherlands : A cross-sectional study ', The Lancet Infectious Diseases, vol. 20, no. 11, pp. 1273-1280 . https://doi.org/10.1016/S1473-3099(20)30527-2
The Lancet. Infectious Diseases
Lancet Infectious Diseases, 20(11), 1273-1280. Lancet Publishing Group
The Lancet Infectious Diseases
Sikkema, R S, Pas, S D, Nieuwenhuijse, D F, O'Toole, Á, Verweij, J J, van der Linden, A, Chestakova, I, Schapendonk, C, Pronk, M, Lexmond, P, Bestebroer, T, Overmars, R J, van Nieuwkoop, S, van den Bijllaardt, W, Bentvelsen, R G, van Rijen, M M L, Buiting, A G M, van Oudheusden, A J G, Diederen, B M, Bergmans, A M C, van der Eijk, A, Molenkamp, R, Rambaut, A, Timen, A, Kluytmans, J A J W, Oude Munnink, B B, Kluytmans van den Bergh, M F Q & Koopmans, M P G 2020, ' COVID-19 in health-care workers in three hospitals in the south of the Netherlands : a cross-sectional study ', The Lancet Infectious Diseases, vol. 20, no. 11, pp. 1273-1280 . https://doi.org/10.1016/S1473-3099(20)30527-2

Background: 10 days after the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the Netherlands (on Feb 27, 2020), 55 (4%) of 1497 health-care workers in nine hospitals located in the south of the Nether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239a5c56414a553142bf70ceb3ef6a9e
https://research.vu.nl/en/publications/9a6e64eb-4014-47dd-bd4b-66710e70926c

RIG-I-like Receptor Triggering by Dengue Virus Drives Dendritic Cell Immune Activation and TH1 Differentiation

Autor: Ronald J. Overmars, Teunis B. H. Geijtenbeek, Tanja M. Kaptein, Sonja I. Gringhuis, Joris K. Sprokholt, John L. van Hamme

Publikováno v: Journal of immunology (Baltimore, Md., 198(12), 4764-4771. American Association of Immunologists
The Journal of Immunology

Dengue virus (DENV) causes 400 million infections annually and is one of several viruses that can cause viral hemorrhagic fever, which is characterized by uncontrolled immune activation resulting in high fever and internal bleeding. Although the unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c166a4896182813370ba8b51ba14eaef
https://pure.amc.nl/en/publications/rigilike-receptor-triggering-by-dengue-virus-drives-dendritic-cell-immune-activation-and-th1-differentiation(8d7e10b1-e1bd-4983-8feb-bc43699eab15).html