Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Ronald J, Lukas"'
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247825 (2021)
Sleep-related hypermotor epilepsy (SHE) is a group of seizure disorders prominently associated with mutations in nicotinic acetylcholine receptors (nAChR). The most prevalent central nervous system nAChR subtype contains α4 and β2 subunits, in two
Externí odkaz:
https://doaj.org/article/07ca298d117547b49aa1ea572b14b6d4
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213143 (2019)
Central nervous system nicotinic acetylcholine receptors (nAChR) are predominantly of the α4β2 subtype. Two isoforms exist, with high or low agonist sensitivity (HS-(α4β2)2β2- and LS-(α4β2)2α4-nAChR). Both isoforms exhibit similar macroscopic
Externí odkaz:
https://doaj.org/article/36f443dad2634fd983f3d824b9e6f38f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Previous studies have demonstrated immunosuppressive and anti-inflammatory effects of nicotine, including in the experimental autoimmune encephalomyelitis (EAE) model in mice of some forms of multiple sclerosis (MS). Other studies using knock-out (KO
Externí odkaz:
https://doaj.org/article/de37db52c12d4602bf19b29a5a45e26a
Autor:
Paul Whiteaker, Heather A. Bimonte-Nelson, Marina R. Picciotto, John R. Cirrito, Jaime M. Vieira, Ronald J. Lukas, Cameron Xavier-Jackson, Michael T. Gee, Andrew A. George
Publikováno v:
The Journal of Neuroscience. 41:555-575
Neuronal and network-level hyperexcitability is commonly associated with increased levels of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease (AD). However, the mechanistic complexity underlying the selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345ae5ac5686788d47017aa6a8cd8d74
https://doi.org/10.1523/jneurosci.0876-20.2020
https://doi.org/10.1523/jneurosci.0876-20.2020
Autor:
Qinhui Zhang, Yingjie Du, Jianliang Zhang, Xiaojun Xu, Fenqin Xue, Cong Guo, Yao Huang, Ronald J Lukas, Yongchang Chang
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137588 (2015)
The α7nicotinic receptor (nAChR) is a major subtype of the nAChRs in the central nervous system, and the receptor plays an important role in brain function. In the dbSNP database, there are 55 single nucleotide polymorphisms (SNPs) that cause missen
Externí odkaz:
https://doaj.org/article/500ffc27e88949689e91321d353a0df7
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134409 (2015)
The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel widely expressed in vertebrates and is associated with numerous physiological functions. As transmembrane ion channels, α7-nAChRs need to be expressed on the surface
Externí odkaz:
https://doaj.org/article/70bf3ea362464732a5e9d11349f01aa3
Autor:
Chao Zheng, Xiao-Kuang K Ma, Ze-Gang Ma, Jie Wu, Yuan-Bing Huang, Devin H Taylor, Ming Gao, Ronald J. Lukas
Publikováno v:
Acta Pharmacol Sin
Nicotine, a major component of tobacco, is highly addictive and acts on nicotinic acetylcholine receptors (nAChRs) to stimulate reward-associated circuits in the brain. It is well known that nAChRs play critical roles in mediating nicotine reward and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1018788b8603b467315c57f27ae5c1
https://europepmc.org/articles/PMC8975845/
https://europepmc.org/articles/PMC8975845/
Autor:
Ze gang Ma, Ronald J. Lukas, Janet L. Neisewander, Xiao kuang Ma, Jason Brek Eaton, Yong chang Chang, Ming Gao, Nan Jiang, Paul Whiteaker, Jie Wu, Yuan bing Huang
Publikováno v:
Acta Pharmacologica Sinica. 41:163-172
Cocaine is one of the most abused illicit drugs worldwide. It is well known that the dopamine (DA) transporter is its major target; but cocaine also acts on other targets including nicotinic acetylcholine receptors (nAChRs). In this study, we investi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93be42d1f6d4d5c3208cba847c3d6540
https://doi.org/10.1038/s41401-019-0276-y
https://doi.org/10.1038/s41401-019-0276-y
Autor:
Andrew A, George, Jaime M, Vieira, Cameron, Xavier-Jackson, Michael T, Gee, John R, Cirrito, Heather A, Bimonte-Nelson, Marina R, Picciotto, Ronald J, Lukas, Paul, Whiteaker
Publikováno v:
J Neurosci
Neuronal and network-level hyperexcitability is commonly associated with increased levels of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease (AD). However, the mechanistic complexity underlying the selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95695bbd8684eb1ac868a5088078b1ca
https://pubmed.ncbi.nlm.nih.gov/33239400
https://pubmed.ncbi.nlm.nih.gov/33239400
Autor:
Lin Chen, Christopher R. Hughes, Henry A. Lester, Ronald J. Lukas, Aaron L. Nichols, Gaurav Advani, J. Brek Eaton, Kaori Noridomi, Richard W. Roberts, Farzad Jalali-Yazdi, Lan Huong Lai
Publikováno v:
ACS Chem Biol
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that play a central role in neuronal and neuromuscular signal transduction. Here, we have developed FANG ligands, fibronectin antibody-mimetic nicotinic acetylcholine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02d0b2ee1d50f827a1c6fd92e3c7f06
https://doi.org/10.1021/acschembio.8b00513
https://doi.org/10.1021/acschembio.8b00513