Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ronald Honchel"'
Autor:
K. Robie-Suh, Ronald Honchel, Q. Xu, J. Zalkkar, R. Rieves, James J. Chen, R. Callicott, R. Patton, M. Cato, A. Laniyonu, N. Gopee, J. Carraway, I. Krefting
Publikováno v:
Regulatory Toxicology and Pharmacology. 60:318-322
The United States Pharmacopeia (USP) monograph for unfractionated heparin (UFH) was revised in October 2009. This revision was anticipated, based upon in vitro tests, to reduce UFH potency by approximately 10%. To study the potential in vivo conseque
Autor:
Ronald Honchel, Ronald D. Snyder, James L. Weaver, Federico Goodsaid, Irwin Y. Rosenblum, Alan Knapton, Frank D. Sistare, Eugene H. Herman, Terry J. Miller, Parvaneh Espandiari, Joseph P. Hanig, Jun Zhang
Publikováno v:
Toxicologic Pathology. 36:827-839
Histopathological and immunohistochemical studies were conducted to characterize vascular injuries in rats treated with phosphodiesterase (PDE) IV inhibitors SCH 351591 or SCH 534385. Sprague-Dawley rats were administered PDE IV inhibitors by gavage
Autor:
Nader Rifai, Helen V. Ratajczak, Eugene H. Herman, Raymond E. Stoll, Frank D. Sistare, Alan Knapton, Kerry T. Blanchard, Donald G. Robertson, Jun Zhang, Michael D. Reily, Ronald Honchel
Publikováno v:
Toxicologic Pathology. 34:152-163
The cardiovascular injury of the type III selective PDE inhibitor SK&F 95654 was investigated in SHR. Twenty-four hours after a single sc injection of 100 or 200 mg/kg of the drug, rats exhibited cardiomyocyte necrosis and apoptosis, interstitial inf
Publikováno v:
International Journal of Toxicology. 21:65-79
Transgenic mouse strains with genetic alterations known to play a role in the multistage process of carcinogenesis are being used increasingly as models for evaluating the human carcinogenic potential of chemicals and Pharmaceuticals. The Tg.AC trans
Autor:
Noralane M. Lindor, Kevin C. Halling, Ronald Honchel, Carola A.S. Arndt, Steven M. Powell, José A. Bufill, Carlo R. Lazzaro
Publikováno v:
Human Heredity. 49:97-102
Two families with autosomal dominantly inherited desmoid tumors have recently been shown to have germline mutations at the 3′ end of the APC gene. We subsequently identified an Amish family with autosomal dominantly inherited desmoid tumors. Geneti
Publikováno v:
Cancer. 76:1765-1771
Background. Tumors from patients with hereditary nonpolyposis colorectal cancer (HNPCC) and from a subset of patients with the related Muir-Torre syndrome (MTS) exhibit a novel type of genomic instability known as microsatellite instability (MIN). In
Autor:
Eun Y. Lee, Luis S. Marsano, Steven I. Shedlofsky, Mukunda B. Ray, Craig J. McClain, Ronald Honchel, Donald A. Cohen
Publikováno v:
Alcoholism: Clinical and Experimental Research. 16:665-669
Endotoxin administration causes liver injury. Patients with alcoholic liver disease frequently have portal vein and systemic endotoxemia, and some investigators have suggested that endotoxin plays an etiologic role in alcoholic liver injury. Many of
Autor:
Karol L. Thompson, Steven E. Lipshultz, Ronald Honchel, Jacques Retief, Frank D. Sistare, Eugene H. Herman, Jun Zhang, Alan Knapton, Barry A. Rosenzweig
Publikováno v:
Cancer chemotherapy and pharmacology. 66(2)
The antineoplastic anthracycline doxorubicin can induce a dose-dependent cardiomyopathy that limits the total cumulative dose prescribed to cancer patients. In both preclinical and clinical studies, pretreatment with dexrazoxane, an intracellular iro
Autor:
Ronald D. Snyder, Frank D. Sistare, Irwin Y. Rosenblum, James L. Weaver, Joseph P. Hanig, Ronald Honchel, Roger J. Smith, Jun Zhang, Federico Goodsaid, Alan Knapton, Terry J. Miller, Yi-Zhong Gu, Parvaneh Espandiari, Eugene H. Herman
Publikováno v:
Toxicologic pathology. 36(6)
Drug-associated vascular injury can be caused by phosphodiesterase (PDE) IV inhibitors and drugs from several other classes. The pathogenesis is poorly understood, but it appears to include vascular and innate immunological components. This research
Autor:
Jun Zhang, Alan Knapton, Frank D. Sistare, Ronald Honchel, Joseph P. Hanig, Terry J. Miller, Parvaneh Espandiari
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 50(1)
The use of transgenic rodents may overcome many limitations of traditional cancer studies. Regulatory perspectives continue to evolve as new models are developed and validated. The transgenic mouse, K6/ODC, develops epidermal tumors when exposed to g