Výsledky vyhledávání - "Ronald H.A. Plasterk"

The Tc1/mariner Family of Transposable Elements

Autor: Ronald H.A. Plasterk, Henri G.A.M. van Luenen

Publikováno v: Mobile DNA II. :519-532

This chapter describes the family of Tc1/ mariner elements, their mechanism of transposition, and the regulation of transposition. It also talks about a few applications of this family of transposable element in forward and reverse genetics. The tran

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https://doi.org/10.1128/9781555817954.ch22

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Efficient target-selected mutagenesis in Caenorhabditis elegans

Autor: Ronald H.A. Plasterk, Jose van de Belt, Victor Guryev, Josine Mudde, Eelke Gort, Edwin Cuppen, Esther Hazendonk, Isaac J. Nijman

Publikováno v: Genome Research, 17(5), 649-58. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT

Reverse genetic or gene-driven knockout approaches have contributed significantly to the success of model organisms for fundamental and biomedical research. Although various technologies are available for C. elegans, none of them scale very well for

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https://hdl.handle.net/11370/7355649f-e42e-4830-a0eb-a638988fdbc0

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Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway

Autor: Javier F. Cáceres, Ronald H.A. Plasterk, Iain L. Johnstone, Dasa Longman

Publikováno v: Longman, D, Plasterk, R H A, Johnstone, I L & Cáceres, J F 2007, ' Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway ', Genes & Development, vol. 21, no. 9, pp. 1075-85 . https://doi.org/10.1101/gad.417707

The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs). Seven genes (smg-1–7, for suppressor with morphological effect on genitalia) that are essential for NMD were originally identif

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https://doi.org/10.1101/gad.417707

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A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish

Autor: Leonie M. Kamminga, Saskia Houwing, Hans van den Elst, Cecilia B. Moens, Heiko Blaser, Erez Raz, Angélique Girard, Dmitri V. Filippov, Ronald H.A. Plasterk, Eugene Berezikov, Daniela Cronembold, Bruce W. Draper, René F. Ketting, Gregory J. Hannon

Publikováno v: Cell, 129(1), 69-82. CELL PRESS
Cell

Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates, is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component o

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APL-1, a Caenorhabditis elegans protein related to the human β-amyloid precursor protein, is essential for viability

Autor: Jason Lieberthal, Chris Li, Gregory O'Connor, Mindy Markowitz, Angela Hornsten, Richard Malins, Xiaomeng Xu, Lawrence Ha, Shruti Fadia, Isabelle Daigle, Ronald H.A. Plasterk

Publikováno v: Proceedings of the National Academy of Sciences. 104:1971-1976

Dominant mutations in the amyloid precursor protein (APP) gene are associated with rare cases of familial Alzheimer's disease; however, the normal functions of APP and related proteins remain unclear. The nematode Caenorhabditis elegans has a single

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https://doi.org/10.1073/pnas.0603997104

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The Diverse Functions of MicroRNAs in Animal Development and Disease

Autor: Wigard P. Kloosterman, Ronald H.A. Plasterk

Publikováno v: Developmental Cell, 11(4), 441-450. Cell Press

MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been implicated in tissue morphogenesis, cellular proce

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https://doi.org/10.1016/j.devcel.2006.09.009

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Differences in vertebrate microRNA expression

Autor: Eugene Berezikov, Brandon Ason, Diana K. Darnell, Parker B. Antin, Ronald H.A. Plasterk, Beate Wittbrodt, Wigard P. Kloosterman, Jochen Wittbrodt

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14385-14389. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 103(39), 14385-14389. National Academy of Sciences

MicroRNAs (miRNAs) attenuate gene expression by means of translational inhibition and mRNA degradation. They are abundant, highly conserved, and predicted to regulate a large number of transcripts. Several hundred miRNA classes are known, and many ar

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https://doi.org/10.1073/pnas.0603529103

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Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis

Autor: Edwin Cuppen, Joost B. Vos, Hiroyuki Mano, Eugene Berezikov, R. E. Verloop, Shuji Takada, Linda W. van Laake, Jose van de Belt, Victor Guryev, Mark Verheul, Ronald H.A. Plasterk, Marc van de Wetering, Anton Jan van Zonneveld, Geert van Tetering

Publikováno v: Genome Research, 16(10), 1289-1298. Cold Spring Harbor Laboratory Press

icroRNAs are 20- to 23-nucleotide RNA molecules that can regulate gene expression. Currently >400 microRNAs have been experimentally identified in mammalian genomes, whereas estimates go up to 1000 and beyond. Here we show that many more mammalian mi

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https://doi.org/10.1101/gr.5159906

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Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi

Autor: Wouter Koole, Ron J. Romeijn, Marcel Tijsterman, Albert Pastink, Leon H.F. Mullenders, Gijs van Haaften, Joris Pothof, Ronald H.A. Plasterk

Publikováno v: Current Biology, 16(13), 1344-1350. Cell Press

SummaryIonizing radiation is extremely harmful for human cells, and DNA double-strand breaks (DSBs) are considered to be the main cytotoxic lesions induced [1]. Improper processing of DSBs contributes to tumorigenesis, and mutations in DSB response g

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https://doi.org/10.1016/j.cub.2006.05.047

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Approaches to microRNA discovery

Autor: Eugene Berezikov, Edwin Cuppen, Ronald H.A. Plasterk

Publikováno v: Nature Genetics, 38 Suppl, 2-7. Nature Publishing Group

MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several hundred genes encoding miRNAs have been experimentally identified in animals, and many more are predicted by computational methods. How can new miRNAs be discovered and

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https://doi.org/10.1038/ng1794

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