Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Ronald H. Schwartz"'
Autor:
Ronald H. Schwartz, Jonathan D. Powell
Publikováno v:
Stem Cell Therapy for Autoimmune Disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763fa5487df3eee0479d4d126558c0e4
https://doi.org/10.1201/9780367813895-18
https://doi.org/10.1201/9780367813895-18
Publikováno v:
PLoS Biology, Vol 4, Iss 11, p e340 (2006)
Overlapping roles have been ascribed for T cell anergy, clonal deletion, and regulation in the maintenance of peripheral immunological tolerance. A measurement of the individual and additive impacts of each of these processes on systemic tolerance is
Externí odkaz:
https://doaj.org/article/13e5c1f1b8f54566a605be299c33310d
Autor:
Ronald H. Schwartz
Publikováno v:
Ia Antigens ISBN: 9781351073332
Ia Antigens
Ia Antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16934c39768ad9eeb35e6a1f9e3da9a
https://doi.org/10.1201/9781351073332-7
https://doi.org/10.1201/9781351073332-7
Peripheral T cell tolerance is challenging to induce in partially lymphopenic hosts and this is relevant for clinical situations involving transplant tolerance. While the shortage of regulatory cells is thought to be one reason for this, T cell-intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a813a77422856340cb390a7005fdadb7
https://europepmc.org/articles/PMC5687833/
https://europepmc.org/articles/PMC5687833/
Autor:
Christopher C. Goodnow, Carola C. Vinuesa, Andy L Johnson, Heather Domaschenz, L. Aravind, Michael J. Lenardo, Teresa Lambe, Andriy Morgun, Natalia Shulzhenko, Lixin Zheng, Seeyoung Choi, Edyta M. Kucharska, Ronald H. Schwartz, Tanya L. Crockford, Richard J. Cornall
Publikováno v:
Nature immunology
The molecular mechanisms that underpin thymocyte selection remain incompletely defined. Groups led by Love, Gascoigne and Schwartz independently identify Themis, a signaling protein essential for the positive selection of thymocytes. T cell antigen r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f09695b1039631cb52cf82b36f3bd8dd
https://doi.org/10.1038/ni0110-97a
https://doi.org/10.1038/ni0110-97a
Publikováno v:
Immunity. 37(4):735-746
SummaryAfter an immune response, the expanded population of antigen-specific CD4+ T cells contract to steady state levels. We have found that the contraction is neither cell-autonomous nor mediated by competition for generic trophic factors, but regu
Publikováno v:
European Journal of Immunology. 42:2875-2880
The behavior of self-reactive T cells in the peripheral immune system has often been studied by following the fate of adoptively transferred antigen-specific T cells in antigen expressing mice. In most cases, after a period of expansion, such cells u
Autor:
Ronald H. Schwartz, Satoru Ishihara
Publikováno v:
The Journal of Immunology. 187:3292-3299
Most gene promoters have multiple binding sequences for many transcription factors, but the contribution of each of these factors to chromatin remodeling is still unclear. Although we previously found a dynamic change in the arrangement of nucleosome
Autor:
Ronald H. Schwartz, Seeyoung Choi
Publikováno v:
The Journal of Immunology. 187:805-816
Adaptive tolerance is a hyporesponsive state in which lymphocyte Ag receptor signaling becomes desensitized after prolonged in vivo encounter with Ag. The molecular mechanisms underlying this hyporesponsive state in T cells are not fully understood,
Autor:
Pascal Chappert, Ronald H. Schwartz
Publikováno v:
Current Opinion in Immunology. 22:552-559
Anergy is a state of long term hyporesponsiveness in T cells that is characterized by an active repression of TCR signaling and IL-2 expression [1]. Several forms of anergy have been described and the last few years have brought to light an increasin