Zobrazeno 1 - 10
of 1 059
pro vyhledávání: '"Ronald G, Crystal"'
Autor:
Teerapat Rojsajjakul, Nithya Selvan, Bishnu De, Jonathan B. Rosenberg, Stephen M. Kaminsky, Dolan Sondhi, Peter Janki, Ronald G. Crystal, Clementina Mesaros, Richie Khanna, Ian A. Blair
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Friedreich’s ataxia is a degenerative and progressive multisystem disorder caused by mutations in the highly conserved frataxin (FXN) gene that results in FXN protein deficiency and mitochondrial dysfunction. While gene therapy approaches
Externí odkaz:
https://doaj.org/article/86223bf35bfc4a128468812ab0bc1d9b
High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-4 (2023)
Abstract While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling and angiogenesis in some individu
Externí odkaz:
https://doaj.org/article/2599d5fcbaf34d05ac3b5d221e0e91e2
Autor:
Mahboubeh R. Rostami, Philip L. Leopold, Jenifer M. Vasquez, Miguel de Mulder Rougvie, Alya Al Shakaki, Ali Ait Hssain, Amal Robay, Neil R. Hackett, Jason G. Mezey, Ronald G. Crystal
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101136- (2023)
Based on the observation that humans have variable responses of gene expression with the same dose of an adeno-associated vector, we hypothesized that there are deleterious variants in genes coding for processes required for adeno-associated virus (A
Externí odkaz:
https://doaj.org/article/73b7a2384d12426fa4f842d65e87bf60
Autor:
Anna E Camilleri, Michelle Cung, Fiona M Hart, Odelya E Pagovich, Ronald G Crystal, Matthew B Greenblatt, Katie M Stiles
Publikováno v:
JBMR Plus, Vol 7, Iss 4, Pp n/a-n/a (2023)
ABSTRACT Aldehyde dehydrogenase 2 (ALDH2) deficiency affects 35% to 45% of East Asians and 8% of the world population. ALDH2 is the second enzyme in the ethanol metabolism pathway. The common genetic variant ALDH2*2 allele has a glutamic acid‐to‐
Externí odkaz:
https://doaj.org/article/b88e3b5357384e75b5d6185b73f8edcb
Autor:
Nancy P. Y. Chung, K. M. Faisal Khan, Mirko Andreoli, Robert J. Kaner, Sarah L. O’Beirne, Ronald G. Crystal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract With highly active anti-retroviral therapy (HAART), higher incidence of airway abnormalities is common in the HIV population consistent with the concept of accelerated lung “aging”. Our previous findings demonstrated that HIV induces hum
Externí odkaz:
https://doaj.org/article/f42e5997121649f0abaadddb0a9f8bc9
Autor:
Juan L. Rodriguez-Flores, Radja Messai-Badji, Amal Robay, Ramzi Temanni, Najeeb Syed, Monika Markovic, Eiman Al-khayat, Fatima Qafoud, Zafar Nawaz, Ramin Badii, Yasser Al-Sarraj, Hamdi Mbarek, Wadha Al-Muftah, Muhammad Alvi, Mahboubeh R. Rostami, Juan Carlos Martinez Cruzado, Jason G. Mezey, Alya Al Shakaki, Joel A. Malek, Matthew B. Greenblatt, Khalid A. Fakhro, Khaled Machaca, Ajayeb Al-Nabet, Nahla Afifi, Andrew Brooks, Said I. Ismail, Asmaa Althani, Ronald G. Crystal
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-21 (2022)
Abstract Risk genes for Mendelian (single-gene) disorders (SGDs) are consistent across populations, but pathogenic risk variants that cause SGDs are typically population-private. The goal was to develop “QChip1,” an inexpensive genotyping microar
Externí odkaz:
https://doaj.org/article/37726560b48d41ea9a863392829c265f
Autor:
Mahboubeh R. Rostami, Michelle G. LeBlanc, Yael Strulovici-Barel, Wulin Zuo, Jason G. Mezey, Sarah L. O’Beirne, Robert J. Kaner, Philip L. Leopold, Ronald G. Crystal
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-17 (2021)
Abstract The club cell, a small airway epithelial (SAE) cell, plays a central role in human lung host defense. We hypothesized that subpopulations of club cells with distinct functions may exist. The SAE of healthy nonsmokers and healthy cigarette sm
Externí odkaz:
https://doaj.org/article/08d73db7b3394c4286f74267ce717330
Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids
Autor:
Sarah L. O’Beirne, Jacqueline Salit, Robert J. Kaner, Ronald G. Crystal, Yael Strulovici-Barel
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter SARS-CoV-2. Epidemiol
Externí odkaz:
https://doaj.org/article/cd423978c73e4b28b23aeac1a498ee54
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background Lysophosphatidic acid (LPA), generated extracellularly by the action of autotaxin and phospholipase A2, functions through LPA receptors (LPARs) or sphingosine-1-phosphate receptors (S1PRs) to induce pro-fibrotic signaling in the l
Externí odkaz:
https://doaj.org/article/9e2d4f908e8c4f36b832ace6bff5acbd
Autor:
Ashish Saxena, Matthew S. Walters, Jae-Hung Shieh, Ling-Bo Shen, Kazunori Gomi, Robert J. Downey, Ronald G. Crystal, Malcolm A. S. Moore
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract The human airway epithelium lining the bronchial tree contains basal cells that proliferate, differentiate, and communicate with other components of their microenvironment. One method that cells use for intercellular communication involves t
Externí odkaz:
https://doaj.org/article/92449e126f694f7d8e77c16977597922