Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ronald F. Gautieri"'
Publikováno v:
Journal of Pharmaceutical Sciences. 69:703-706
This investigation revealed that cocaine hydrochloride was teratogenic when administered in nontoxic doses to gravid CF-1 mice on Days 7-12 of gestation. The teratogenic susceptibility of the CF-1 mouse fetus to cocaine hydrochloride was evident thro
Publikováno v:
Journal of Pharmaceutical Sciences. 70:631-634
Single administrations of cortisone or phenytoin to pregnant mice on Days 11--14 of gestation caused similar skeletal and dissimilar soft tissue fetal anomalies. Cortisone reduced both maternal and fetal weight, whereas phenytoin only reduced fetal w
Autor:
Ronald F. Gautieri, John E. Zellers
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1727-1731
The most prominent defect of codeine sulfate, 100 mg/kg sc, was delayed ossification of the supraoccipital bone, paws, xiphoid, and sternebrae as well as other sternebral defects such as checkerboard sternebrae and polysternebrae. Although these anom
Autor:
Arthur A. Ciociola, Ronald F. Gautieri
Publikováno v:
Pharmaceutical Research. :447-452
Physical and behavioral anomalies of fetal alcohol syndrome were studied after the i.p. administration of a single 3- or 6-g/kg dose of ethanol (25%, v/v) to gravid mice on either day 15 or day 18 of gestation. The physical effects of ethanol adminis
Publikováno v:
Journal of Pharmaceutical Sciences. 67:377-380
Various cobalt-containing agents (cyanocobalamin, sodium cobaltinitrite, and cobaltous chloride), which formerly had been shown to prevent the onset of cleft palate in CF-1 mice injected with cortisone, were studied to determine whether they would af
Autor:
Ralph T. Mancini, Ronald F. Gautieri
Publikováno v:
Journal of Pharmaceutical Sciences. 53:1476-1481
The effects of three adrenergic blocking agents (phentolamine, tolazoline, and hydralazine) on the action of epinephrine, norepinephrine, l -epinephrine, histamine, and 5-hydroxytryptamine in placental vessels were investigated. The results indicated
Autor:
Ronald F. Gautieri, David E. Mann
Publikováno v:
Journal of Pharmaceutical Sciences. 50:556-560
The results indicate that gonadectomy without further treatment, other than the application of the MCD 50 of methylcholanthrene, did not affect the tumor incidence. Intact or gonadectomized females showed an increased tumor incidence when subjected t
Publikováno v:
Journal of Pharmaceutical Sciences. 54:595-598
Chronic hypoxia induced by the oral ingestion of nitrites yielded significant reductions in the tumor incidence of animals exposed to the minimal carcinogenic dose 50 of methylcholanthrene. Sodium cobaltinitrite was a more effective antitumorigenic a
Autor:
Robert S. Thompson, Ronald F. Gautieri
Publikováno v:
Journal of Pharmaceutical Sciences. 58:406-412
The incidence of anomalies in untreated and saline-treated controls (both s.c. and i.v.) was 1.5 and 0.26 percent, respectively. Subcutaneous administration of serotonin at mg./mouse and 10 mg./kg. produced respective incidences of 24.4 and 27.0 perc
Autor:
Ronald F. Gautieri, Henry P. Ciuchta
Publikováno v:
Journal of Pharmaceutical Sciences. 53:184-188
Perfusion studies conducted on full term human placentas indicated that histamine and serotonin consistently cause marked increases in perfusion pressure. A moderate increase in pressure was observed in response to epinephrine and l -epinephrine. In