Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ronald F. Ertl"'
Cultured Lung Fibroblasts from Ovalbumin-Challenged 'Asthmatic' Mice Differ Functionally from Normal
Autor:
Lijun Mao, Shinsaku Togo, Hisatoshi Sugiura, Fenghai Duan, Shin Kawasaki, Thomas B. Casale, Ronald F. Ertl, Stephen I. Rennard, Koichiro Kamio, Xingqi Wang, Youngsoo Ahn, A.I. Berro, Xiangde Liu, Tom Bargar
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 37:424-430
Asthmatic airway remodeling is characterized by goblet cell hyperplasia, angiogenesis, smooth muscle hypertrophy, and subepithelial fibrosis. This study evaluated whether acquired changes in fibroblast phenotype could contribute to this remodeling. A
Autor:
Koichiro Kamio, Shinsaku Togo, Xingqi Wang, Lei Shen, Hisatoshi Sugiura, Xiangde Liu, Stephen I. Rennard, Tetsu Kobayashi, Lijun Mao, Cory M. Hogaboam, Shin Kawasaki, Ronald F. Ertl
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 34:592-599
Reactive nitrogen species (RNS) such as peroxynitrite cause cellular injury and tissue inflammation. Excessive production of nitrotyrosine, which is a footprint of RNS, has been observed in the airways of patients with asthma and chronic obstructive
Autor:
Masashi Kawamoto, Stephen I. Rennard, John R. Spurzem, Yoichi Nakamura, Debra J. Romberger, Luigi Allegra, Tadashi Kohyama, Tom Veys, Ronald F. Ertl, Vincenzo Valenti
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1257-L1263
Fibroblasts are the major source of extracellular connective tissue matrix, and the recruitment, accumulation, and stimulation of these cells are thought to play important roles in both normal healing and the development of fibrosis. Prostaglandin E2
Autor:
John R. Spurzem, Debra J. Romberger, Fu Qiang Wen, Yun Kui Zhu, Ronald F. Ertl, Stephen I. Rennard, Xiangde Liu, Hangjun Wang, Tadashi Kohyama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:620-627
Proteolytic degradation of extracellular matrix is thought to play an important role both in emphysema and in tissue development and repair. Retinoic acid has been suggested to modify tissue injury, and in an animal model of emphysema may induce alve
Autor:
Ronald F. Ertl, Fu Qiang Wen, C. Magnus Sköld, Tadashi Kohyama, Xiang Der Liu, Hangjun Wang, Stephen I. Rennard, Yun Kui Zhu
Publikováno v:
Inflammation. 25:109-117
TGF-β plays a central role in the initiation and progression of pulmonary fibrosis. Glucocorticoids are frequently used to treat fibrotic diseases, but beneficial effects are often modest. Both TGF-β and glucocorticoids have been reported to increa
Autor:
Takeshi Umino, C. M. Skold, Xiangde Liu, Ronald F. Ertl, Debra J. Romberger, Yunkui Zhu, S. I. Rennard
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 279:L667-L674
Mononuclear phagocytes can interact with mesenchymal cells and extracellular matrix components that are crucial for connective tissue rearrangement. We asked whether blood monocytes can alter matrix remodeling mediated by human lung fibroblasts cultu
Autor:
David M. Daughton, Jiro Takahara, Stephen I. Rennard, Ronald F. Ertl, Jiro Fujita, C. Magnus Sköld
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 160:802-807
Human neutrophil elastase (HNE), an enzyme secreted by activated neutrophils, can bind to and degrade extracellular matrix including human lung elastin. This protease is believed to play an important role in several destructive processes including pu
Autor:
Keiichi Takigawa, Debra J. Romberger, Takeshi Umino, Yoshihiro Ohkuni, Ralph Lennart Brattsand, C. Magnus Sköld, Yun Kui Zhu, Stephen I. Rennard, Ronald F. Ertl, Xiang Der Liu, John R. Spurzem
Publikováno v:
Proceedings of the Association of American Physicians. 111:249-258
Glucocorticoids are currently regarded as the drug of choice in the treatment of inflammatory airway and lung diseases, however, they are not routinely effective in fibrotic phases of inflammation. In the current study, glucocorticoids were investiga
Autor:
Xiangde Liu, Tom Veys, Stephen I. Rennard, Debra J. Romberger, John R. Spurzem, M. Cano, Takeshi Umino, Ronald F. Ertl
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 274:L58-L65
Fibroblasts can contract collagen gels, a process thought to be related to tissue remodeling. Because epithelial cells are also involved in repair responses, we postulated that human bronchial epithelial cells (HBECs) could cause contraction of colla
Publikováno v:
Europe PubMed Central
The released neutrophil chemotactic activity (NCA) from bronchial epithelial cells (BECs) in response to smoke extract was evaluated by reverse-phase, high-performance liquid chromatography (RP-HPLC) and the involvement of proteolytic activity was as