Zobrazeno 1 - 10
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pro vyhledávání: '"Ronald F. Cookson"'
Publikováno v:
PharmacoEconomics. 14:285-297
Objective:We constructed a UK-based decision model of palliative care for terminally ill cancer patients who were switched from a weak to a strong opioid so that the expected direct healthcare costs in the UK could be estimated from the time a patien
Autor:
Ronald F Cookson, Krista F Huybrechts
Publikováno v:
Journal of Medical Economics. 1:103-134
SummaryA variety of economic studies have been carried out in Europe, North America and Australia. Risperidone is dominant over haloperidol, providing both an improvement in patient benefit and decreasing direct medical costs. These effects are most
Publikováno v:
Organic Mass Spectrometry. 13:341-343
A combination of electron impact, chemical ionization, field desorption and field ionization mass spectrometry has been employed to demonstrate that the LAH reduction product of 3H-1,2-benzodithiole-3-thione is the dimer, dibenzo[c,h]-3H,10H-dihydro-
Autor:
Ronald F. Cookson, Alan C. Richards
Publikováno v:
Chemischer Informationsdienst. 5
1,2,5-Thiadiazole, previously thought to be resistant to electrophilic substitution, has been shown to undergo chloromethylation; N-chlorosuccinimide is more selective than N-bromosuccinimide in the dihalogenation of 3,4-dimethyl-1,2,5-thiadiazole.
Publikováno v:
Chemischer Informationsdienst. 6
Treatment of the phenacyl quaternary salts of isoquinoline and quinoline with ammonium acetate in acetic acid gave the products (5) and (7) respectively, and not those previously reported.
Autor:
RONALD F. COOKSON, RONALD E. RODWAY
Publikováno v:
Chemischer Informationsdienst. 6
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :201
Treatment of 2-phenacylisoquinolinium bromide with ammonium acetate in acetic acid gave 5,10-dihydro-2-phenylimidazo[1,2-b]isoquinoline (4) by cyclisation at the 3-position of the isoquinoline ring. The mechanism of this reaction is discussed. On sim
Autor:
Ronald F. Cookson, Ronald E. Rodway
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1854
Heating 2-aminoethylammonium tosylate (EDMT) with various aromatic bicyclic amides at 200–250 °C provides a convenient single-stage synthesis of the corresponding dihydroimidazo-compounds. The procedure worked well with phthalazinones (1), quinolo
Autor:
Ronald F. Cookson, Ronald E. Rodway
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1850
Phenanthridone reacts with 2-aminoethylammonium tosylate at 200–250 °C to give 2,3-dihydroimidazo[1,2-f]-phenanthridine (2; R = H) in high yield. This reaction could not be extended to the monotosylate salts of o-phenylenediamine, propane-1,3-diam
Autor:
Alan C. Richards, Ronald F. Cookson
Publikováno v:
Journal of the Chemical Society, Chemical Communications. :585
1,2,5-Thiadiazole, previously thought to be resistant to electrophilic substitution, has been shown to undergo chloromethylation; N-chlorosuccinimide is more selective than N-bromosuccinimide in the dihalogenation of 3,4-dimethyl-1,2,5-thiadiazole.