Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ronald Eugene White"'
Autor:
Michelle Hare, Jackson Christopher M, Bin Fang, Gina M. Fadayel, Richard Hedges, Michael Murawsky, Benjamin E. Blass, Jim Sheffer, Laurent Djandjighian, Ronald Eugene White, Andrew J. Fluxe, John Michael Janusz, Shengde Wu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6213-6218
A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC50s ranging from 180 to 550 nM. In vivo studies indicated that compounds 2f and 2j increased right atrial ERP about 40% without affecting ven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f23ce66fd7f547364b8f2a57760b9d64
https://doi.org/10.1016/j.bmcl.2006.09.021
https://doi.org/10.1016/j.bmcl.2006.09.021
Autor:
Wei-Ping Lu, Jean-Marie Frère, Astrid Zervosen, Zhouliang Chen, Thomas P. Demuth, Ronald Eugene White
Publikováno v:
Antimicrobial Agents and Chemotherapy. 48:961-969
Several non-β-lactam compounds were active against various gram-positive and gram-negative bacterial strains. The MICs of arylalkylidene rhodanines and arylalkylidene iminothiazolidin-4-ones were lower than those of ampicillin and cefotaxime for met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6270fcbd96868a254a00249fc5a109a6
https://doi.org/10.1128/aac.48.3.961-969.2004
https://doi.org/10.1128/aac.48.3.961-969.2004
Autor:
Steve Hodson, Shengde Wu, Neil T. Fairweather, Andrew J. Fluxe, Benjamin E. Blass, Jim Ridgeway, John J. Janusz, Ronald Eugene White, Wenlin Lee, Keith R. Coburn, Jackson Christopher M
Publikováno v:
Tetrahedron Letters. 47:7497-7499
An examination of the methods required for the amination of 2- and 4-imidazolidinones is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fafb9bf3baa298e07e257239540be4a
https://doi.org/10.1016/j.tetlet.2006.08.022
https://doi.org/10.1016/j.tetlet.2006.08.022
Autor:
Ronald Eugene White, Laurent Djandjighian, Andrew J. Fluxe, John Michael Janusz, Shengde Wu, Steven J. Hodson, James M. Ridgeway, Benjamin E. Blass, Gina M. Fadayel, Keith R. Coburn, Jackson Christopher M, Michael Murawsky
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(1)
Blockade of the Kv1.5 ion channel is a potentially atrial-selective avenue for the treatment of atrial fibrillation and atrial flutter. The development and biological evaluation of a series of thiazolidine-based blockers of Kv1.5 is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508dd9d9cdd8307bb20a62cf10dcf507
https://pubmed.ncbi.nlm.nih.gov/17095219
https://pubmed.ncbi.nlm.nih.gov/17095219
Autor:
Ronald Eugene White, Amanda L. Ritter, John Michael Janusz, Bin Fang, Wenlin Lee, Michael Murawsky, Benjamin E. Blass, Andrew J. Fluxe, Michelle Hare, Jim Ridgeway, Neil T. Fairweather, Keith R. Coburn, Jackson Christopher M, Laurent Djandjighian, Fred C. Wireko, Shengde Wu, Gina M. Fadayel, Richard Hedges
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(17)
A series of novel (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of atrial fibrillation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2a5a21600156b3b618df2d75e9f923
https://pubmed.ncbi.nlm.nih.gov/16793267
https://pubmed.ncbi.nlm.nih.gov/16793267
Autor:
Zhuoliang Chen, Ronald Eugene White, Siddhartha Roychoudhury, Wei-Ping Lu, Thomas P. Demuth, Jessica L. Brill
Publikováno v:
Journal of biomolecular screening. 8(5)
An assay quantifying the loss of antibacterial potency of compounds, originally identified via target-based screening, in the presence of increasing albumin concentration was developed and used as a technique to measure potential association of compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eedb137afa66c85bf2c095cfcfdb217f
https://pubmed.ncbi.nlm.nih.gov/14567782
https://pubmed.ncbi.nlm.nih.gov/14567782