Výsledky vyhledávání - "Ronald E. Tynes"

Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells

Autor: Uta Eckhardt, Bruno Hagenbuch, Lukas Landmann, Ronald E. Tynes, Bruno Stieger, Mathias Höchli, Peter J. Meier, Alice Schroeder

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 276:G1037-G1042

The rat liver organic anion transporting polypeptide (Oatp1) has been extensively characterized mainly in the Xenopus laevis expression system as a polyspecific carrier transporting organic anions (bile salts), neutral compounds, and even organic cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a4fe73f6bd2ac8dbdb55e10385405e
https://doi.org/10.1152/ajpgi.1999.276.4.g1037

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Kinetic Analysis of the Activation of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by Heterologously Expressed Human P450 Enzymes and the Effect of P450- Specific Chemical Inhibitors on This Activation in Human Liver Microsomes

Autor: Patrick Koch, Theresa J. Smith, Chung S. Yang, Ronald E. Tynes, Christopher J. Patten, Mong Heng Wang, Sharon E. Murphy, Jae Lee

Publikováno v: Archives of Biochemistry and Biophysics. 333:127-138

The tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is enzymatically activated by the hydroxylation of the alpha-methyl and alpha-methylene groups, leading to the formation of reactive species which can pyridyloxobutylate and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af108612b4c72af00d3802164d9faf32
https://doi.org/10.1006/abbi.1996.0373

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The flavin-containing monooxygenase enzymes expressed in rabbit liver and lung are products of related but distinctly different genes

Autor: Richard M. Philpot, Ronald E. Tynes, M.P. Lawton, E Hodgson, Rodolfo Gasser

Publikováno v: Journal of Biological Chemistry. 265:5855-5861

Preparations of mRNA isolated from rabbit lung and liver were used in the construction of libraries that were screened for cDNAs encoding the pulmonary or hepatic isozyme of the flavin-containing monooxygenase. The hepatic library was screened with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b742cdb25f2df019d11b1d833c9fbae
https://doi.org/10.1016/s0021-9258(19)39441-4

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Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells

Autor: Bruno Hagenbuch, Alice Schroeder, Uta Eckhardt, Peter J. Meier, Claudio D. Schteingart, Alan F. Hofmann, Ronald E. Tynes, Bruno Stieger

Publikováno v: The American journal of physiology. 274(2)

It has been proposed that the hepatocellular Na+-dependent bile salt uptake system exhibits a broad substrate specificity in intact hepatocytes. In contrast, recent expression studies in mammalian cell lines have suggested that the cloned rat liver N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6249301d9abf5c609394f45e381591ef
https://pubmed.ncbi.nlm.nih.gov/9486191

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Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes

Autor: Mark J. Friesen, Christopher J. Patten, Teresa J. Smith, Sharon E. Murphy, C. S. Yang, Ronald E. Tynes

Publikováno v: Carcinogenesis. 18(8)

The tobacco specific carcinogen N'-nitrosonornicotine (NNN), is believed to be a causative agent for esophageal cancer in smokers. NNN requires metabolic activation to exert its carcinogenic potential. Metabolism occurs through cytochrome P450 (P450)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6b6e78936e5fbd4eedec7d4101d87a
https://pubmed.ncbi.nlm.nih.gov/9276639

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Oxidation of thiobenzamide by the fad-containing and cytochrome P-450-dependent monooxygenases of liver and lung microsomes

Autor: Ronald E. Tynes, Ernest Hodgson

Publikováno v: Biochemical Pharmacology. 32:3419-3428

Two distinct microsomal pathways involved in the metabolism of thiobenzamide to thiobenzamide S -oxide have been identified and quantitated in the liver and lungs of mice and rats, using a highly inhibitory antibody against NADPH-cytochrome P-450 red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ea1cac6ab0f24041705a4ee8c03630
https://doi.org/10.1016/0006-2952(83)90371-4

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Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit

Autor: Ernest Hodgson, Ronald E. Tynes, Patrick J. Sabourin

Publikováno v: Biochemical and Biophysical Research Communications. 126:1069-1075

The flavin-containing monooxygenase has been purified from mouse and rabbit lung microsomes and shown to be distinct from the flavin-containing monooxygenase found in the liver of the same species. The mouse and rabbit lung monooxygenases have a uniq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f81663295e3bbac800b4d3d74731bf1
https://doi.org/10.1016/0006-291x(85)90294-3

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